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Oncogenic And Tumor Suppressor Function Of Meis And Associated Factors, Bi̇rkan Gi̇rgi̇n, Medi̇ne Karadağ Alpaslan, Fati̇h Kocabaş
Oncogenic And Tumor Suppressor Function Of Meis And Associated Factors, Bi̇rkan Gi̇rgi̇n, Medi̇ne Karadağ Alpaslan, Fati̇h Kocabaş
Turkish Journal of Biology
MEIS proteins are historically associated with tumorigenesis, metastasis, and invasion in cancer. MEIS and associated PBXHOX proteins may act as tumor suppressors or oncogenes in different cellular settings. Their expressions tend to be misregulated in various cancers. Bioinformatic analyses have suggested their upregulation in leukemia/lymphoma, thymoma, pancreas, glioma, and glioblastoma, and downregulation in cervical, uterine, rectum, and colon cancers. However, every cancer type includes, at least, a subtype with high MEIS expression. In addition, studies have highlighted that MEIS proteins and associated factors may function as diagnostic or therapeutic biomarkers for various diseases. Herein, MEIS proteins and associated factors in …