Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 2 of 2
Full-Text Articles in Life Sciences
Profiling The Macrofilaricidal Effects Of Flubendazole On Adult Female Brugia Malayi Using Rnaseq, Maeghan O'Neill, Cristina Ballesteros, Lucienne Tritten, Erica Burkman, Weam I. Zaky, Jianguo Xia, Andrew Moorhead, Steven A. Williams, Timothy G. Geary
Profiling The Macrofilaricidal Effects Of Flubendazole On Adult Female Brugia Malayi Using Rnaseq, Maeghan O'Neill, Cristina Ballesteros, Lucienne Tritten, Erica Burkman, Weam I. Zaky, Jianguo Xia, Andrew Moorhead, Steven A. Williams, Timothy G. Geary
Biological Sciences: Faculty Publications
The use of microfilaricidal drugs for the control of onchocerciasis and lymphatic filariasis (LF) necessitates prolonged yearly dosing. Prospects for elimination or eradication of these diseases would be enhanced by the availability of a macrofilaricidal drug. Flubendazole (FLBZ), a benzimidazole anthel- mintic, is an appealing candidate. FLBZ has demonstrated potent macrofilaricidal effects in a number of experimental rodent models and in one human trial. Unfortunately, FLBZ was deemed unsatisfactory for use in mass drug administration campaigns due to its limited oral bioavailability. A new formulation that enables sufficient bioavailability following oral administration could render FLBZ an effective treatment for onchocerciasis …
Reproductive Effort In Squirrels: Ecological, Phylogenetic, Allometric, And Latitudinal Patterns, Virginia Hayssen
Reproductive Effort In Squirrels: Ecological, Phylogenetic, Allometric, And Latitudinal Patterns, Virginia Hayssen
Biological Sciences: Faculty Publications
The distinctive features of reproduction in squirrels are the lack of allometric influences on the duration of reproductive investment; the strong allometric influences on offspring mass; and a trade-off between number and size of young, suggesting an important developmental component to reproduction. Lengths of gestation and lactation do not vary with body size but neonatal and weaning mass do. Apparently, the major constraint on reproduction in squirrels is not resources per se (food, calories, minerals, or water) but rather the length of time such resources are available. Squirrels adjust growth rate to fit the timing of resource abundance. Within the …