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Co-Encapsulation Of Gallium With Gentamicin In Liposomes Enhances Antimicrobial Activity Of Gentamicin Against Pseudomonas Aeruginosa, Majed Halwani, B. Yebio, Zacharias E. Suntres, M. Alipour, Ali Azghani, A. Omri
Co-Encapsulation Of Gallium With Gentamicin In Liposomes Enhances Antimicrobial Activity Of Gentamicin Against Pseudomonas Aeruginosa, Majed Halwani, B. Yebio, Zacharias E. Suntres, M. Alipour, Ali Azghani, A. Omri
Ali Azghani
The aim of this study was to enhance the antimicrobial efficacy of a liposomal gentamicin formulation with gallium metal (Lipo-Ga-GEN) against clinical isolates of Pseudomonas aeruginosa.
Sputum isolates of P. aeruginosa from cystic fibrosis patients were used to determine the MIC and MBC of Lipo-Ga-GEN. P. aeruginosa biofilms were formed and used to compare the minimum biofilm eradication concentration of the conventional drugs with that of Lipo-Ga-GEN. Quorum sensing (QS) molecule reduction of P. aeruginosa was determined by monitoring N-acyl homoserine lactone production using Agrobacterium tumefaciens reporter strain (A136). Viability of the cultured human lung epithelial cells (A549) was determined …