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Full-Text Articles in Life Sciences
Prediction Of Parturition And Dystocia In Holstein-Friesian Cattle, And Cesarean Section In Dystocic Beef Cattle, Wen Han Mark Hiew
Prediction Of Parturition And Dystocia In Holstein-Friesian Cattle, And Cesarean Section In Dystocic Beef Cattle, Wen Han Mark Hiew
Open Access Dissertations
Dystocia is a major problem in the dairy industry as it causes livestock and economic loss. It is more frequently seen in primiparous cattle compared to their multiparous counterparts due to their smaller stature and the slow maturation of pelvic dimensions. In some instances, human intervention of the parturition process is imperative to avoid pain, injury, and mortality of the neonate and the dam. The ability to accurately predict dystocia and the time of parturition will ensure that timely assistance can be given to animals that are of high risk of dystocia.^ The present thesis contains four studies that explore …
Cellular And Molecular Regulation Of Skeletal Muscle Regeneration, Chunhui Jiang
Cellular And Molecular Regulation Of Skeletal Muscle Regeneration, Chunhui Jiang
Open Access Dissertations
Skeletal muscle regeneration provides a powerful model to study the cellular and molecular mechanism governing stem cell function since the whole process is mediated by a population of muscle-resident stem cells called satellite cells. The overall aim of this dissertation is to explore the roles of Notch signaling and a novel gene (Bex1) in satellite cell function and skeletal muscle regeneration. ^ The first part of this thesis is to examine how the Notch signaling pathway regulates the satellite cell self-renewal in a disease model. The MDX mouse is a well-established model for Duchenne muscular dystrophy (DMD) and characterized by …
Karyopherin Alpha Subtypes And Porcine Early Stage Embryo Development, Yanfang Li
Karyopherin Alpha Subtypes And Porcine Early Stage Embryo Development, Yanfang Li
Open Access Dissertations
Intracellular communication between the nucleus and cytoplasm is critically important for coordinating cellular events during embryogenesis. The karyopherin α/β heterodimer is an intracellular nuclear trafficking system that mediates nuclear import of proteins that bear classical nuclear localization signals (NLSs). Seven karyopherin α subtypes have been identified in the domestic pig, and while each of these karyopherin α subtypes is able to bind to a nuclear localization signal, individual karyopherin α subtypes have been shown to transport specific NLS-bearing proteins. The objective of this study was to determine the developmental requirements of karyopherin α subtypes (KPNAs) during cleavage development in porcine …