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Activation Of Gper Induces Differentiation And Inhibition Of Coronary Artery Smooth Muscle Cell Proliferation, F. Li, X. Yu, C. K. Szynarski, C. Meng, B. Zhou, R. Barhoumi, Richard E. White, C. L. Heaps, J. N. Stallone, G. Han
Activation Of Gper Induces Differentiation And Inhibition Of Coronary Artery Smooth Muscle Cell Proliferation, F. Li, X. Yu, C. K. Szynarski, C. Meng, B. Zhou, R. Barhoumi, Richard E. White, C. L. Heaps, J. N. Stallone, G. Han
PCOM Scholarly Papers
Background:Vascular pathology and dysfunction are direct life-threatening outcomes resulting from atherosclerosis or vascular injury, which are primarily attributed to contractile smooth muscle cells (SMCs) dedifferentiation and proliferation by re-entering cell cycle. Increasing evidence suggests potent protective effects of G-protein coupled estrogen receptor 1 (GPER) activation against cardiovascular diseases. However, the mechanism underlying GPER function remains poorly understood, especially if it plays a potential role in modulating coronary artery smooth muscle cells (CASMCs).Methodology/Principal Findings:The objective of our study was to understand the functional role of GPER in CASMC proliferation and differentiation in coronary arteries using from humans and swine models. We …