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Articles 1 - 8 of 8
Full-Text Articles in Life Sciences
Exploring The Mialome Of Ticks: An Annotated Catalogue Of Midgut Transcripts From The Hard Tick, Dermacentor Variabilis (Acari: Ixodidae), Jennifer M. Anderson, Daniel E. Sonenshine, Jesus G. Valenzuela
Exploring The Mialome Of Ticks: An Annotated Catalogue Of Midgut Transcripts From The Hard Tick, Dermacentor Variabilis (Acari: Ixodidae), Jennifer M. Anderson, Daniel E. Sonenshine, Jesus G. Valenzuela
Biological Sciences Faculty Publications
Background: Ticks are obligate blood feeders. The midgut is the first major region of the body where blood and microbes ingested with the blood meal come in contact with the tick's internal tissues. Little is known about protein expression in the digestive tract of ticks. In this study, for analysis of global gene expression during tick attachment and feeding, we generated and sequenced 1,679 random transcripts (ESTs) from cDNA libraries from the midguts of female ticks at varying stages of feeding.
Results: Sequence analysis of the 1,679 ESTs resulted in the identification of 835 distinct transcripts, from these, a total …
Comparison Of Dna Pyrosequencing With Alternative Methods For Identification Of Mycobacteria, Loree C. Heller, Michael Jones, Ray H. Widen
Comparison Of Dna Pyrosequencing With Alternative Methods For Identification Of Mycobacteria, Loree C. Heller, Michael Jones, Ray H. Widen
Bioelectrics Publications
Identification of mycobacterial clinical isolates by pyrosequencing within the hypervariable A region of the 16S rRNA gene was compared to other identification methods. For >90% of isolates, these identifications correlated to the level of complex or species. For identification of many mycobacteria, pyrosequencing offers an inexpensive alternative to traditional sequencing.
Turbulent Lifestyle: Microbial Mats On Earth’S Sandy Beaches—Today And 3 Billion Years Ago, Nora Noffke
Turbulent Lifestyle: Microbial Mats On Earth’S Sandy Beaches—Today And 3 Billion Years Ago, Nora Noffke
OES Faculty Publications
Archean Earth history is very difficult to reconstruct. Until recently, only bacterial cells preserved in chert, microborings, and stromatolites provided the few clues to ancient life. Now, siliciclastic “microbially induced sedimentary structures” (MISS) are adding to our knowledge of both past life and paleoenvironments. MISS rise from the interaction of photoautotrophic microbial mats with physical sediment dynamics in siliciclastic, shallow-marine settings. Archean MISS can be understood through observations of living microbial mats and modern biotic-physical sedimentary processes. Such geobiological studies are key to the interpretation of the early evolution of prokaryotes. For example, the 2.9 Ga Pongola Supergroup, South Africa, …
Ship Ballast Tanks: How Microbes Travel The World, Fred C. Dobbs
Ship Ballast Tanks: How Microbes Travel The World, Fred C. Dobbs
OES Faculty Publications
As the international shipping fleet travels the oceans, it carries with it hidden cargoes of microbes. Fred C. Dobbs explores the hazards posed and what can be done to counteract them.
Interactions Between Changing Pco2, N2 Fixation, And Fe Limitation In The Marine Unicellular Cyanobacterium Crocosphaera, Fei-Xue Fu, Margaret R. Mulholland, Nathan S. Garcia, Aaron Beck, Mark E. Warner, Sergio A. Sañudo, David A. Hutchins
Interactions Between Changing Pco2, N2 Fixation, And Fe Limitation In The Marine Unicellular Cyanobacterium Crocosphaera, Fei-Xue Fu, Margaret R. Mulholland, Nathan S. Garcia, Aaron Beck, Mark E. Warner, Sergio A. Sañudo, David A. Hutchins
OES Faculty Publications
We examined the physiological responses of steady-state iron (Fe)-replete and Fe-limited cultures of the biogeochemically critical marine unicellular diazotrophic cyanobacterium Crocosphaera at glacial (19 Pa; 190 ppm), current (39 Pa; 380 ppm), and projected year 2100 (76 Pa; 750 ppm) CO2 levels. Rates of N2 and CO2 fixation and growth increased in step with increasing partial pressure of CO2 (pCO2), but only under Fe- replete conditions. N2) and carbon fixation rates at 75 Pa CO2 were 1.4-1.8-fold and 1.2-2.0-fold higher, respectively, relative to those at present day and glacial pCO2 …
Do Hospitalists Or Physicians With Greater Inpatient Hiv Experience Improve Hiv Care In The Era Of Highly Active Antiretroviral Therapy? Results From A Multicenter Trial Of Academic Hospitalists, John A. Schneider, Qi Zhang, Andrew Auerbach, David Gonzales, Peter Kaboli, Jeffrey Schnipper, Tosha B. Wetterneck, David L. Pitrak, David O. Meltzer
Do Hospitalists Or Physicians With Greater Inpatient Hiv Experience Improve Hiv Care In The Era Of Highly Active Antiretroviral Therapy? Results From A Multicenter Trial Of Academic Hospitalists, John A. Schneider, Qi Zhang, Andrew Auerbach, David Gonzales, Peter Kaboli, Jeffrey Schnipper, Tosha B. Wetterneck, David L. Pitrak, David O. Meltzer
Community & Environmental Health Faculty Publications
Background. Little is known about the effect of provider type and experience on outcomes, resource use, and processes of care of hospitalized patients with human immunodeficiency virus (HIV) infection. Hospitalists are caring for this population with increasing frequency.
Methods. Data from a natural experiment in which patients were assigned to physicians on the basis of call cycle was used to study the effects of provider type—that is, hospitalist versus non hospitalist—and HIV-specific inpatient experience on resource use, outcomes, and selected measures of processes of care at 6 academic institutions. Administrative data, inpatient interviews, 30-day follow-up interviews, and the National Death …
Physical And In Silico Approaches Identify Dna-Pk In A Tax Dna-Damage Response Interactome, Emad Ramadan, Michael Ward, Xin Guo, Sarah S. Durkin, Adam Sawyer, Marcelo Vilela, Christopher Osgood, Alex Pothen, Oliver J. Semmes
Physical And In Silico Approaches Identify Dna-Pk In A Tax Dna-Damage Response Interactome, Emad Ramadan, Michael Ward, Xin Guo, Sarah S. Durkin, Adam Sawyer, Marcelo Vilela, Christopher Osgood, Alex Pothen, Oliver J. Semmes
Biological Sciences Faculty Publications
Background: We have initiated an effort to exhaustively map interactions between HTLV-1 Tax and host cellular proteins. The resulting Tax interactome will have significant utility toward defining new and understanding known activities of this important viral protein. In addition, the completion of a full Tax interactome will also help shed light upon the functional consequences of these myriad Tax activities. The physical mapping process involved the affinity isolation of Tax complexes followed by sequence identification using tandem mass spectrometry. To date we have mapped 250 cellular components within this interactome. Here we present our approach to prioritizing these interactions via …
Subcellular Localization Of Human T-Cell Leukemia Virus Type 1 Tax Oncoprotein, Kimberly Anne Fryrear
Subcellular Localization Of Human T-Cell Leukemia Virus Type 1 Tax Oncoprotein, Kimberly Anne Fryrear
Theses and Dissertations in Biomedical Sciences
Human T-cell Leukemia Virus Type 1 (HTLV-1) is a transforming retrovirus that gives rise to Adult T-cell Leukemia (ATL) and a variety of other subneoplastic conditions such as HTLV-Associated Myelopathy/Tropical Spastic Paraperesis (HAM/TSP). In ATL, the transformation and immortalization of T-lymphocytes has been attributed to the expression and activity of a single HTLV-1 viral protein, namely the trans-activating protein Tax. Although the exact mechanism of Tax-mediated transformation is uncertain, current studies support a model in which Tax induces genomic instability in the host cell through interference with DNA repair mechanisms, dysregulation of cell cycle progression, transcriptional activation of cellular …