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Magnesium Regulation Of Calcium In Essential Hypertension, Elaine Pringle Gordon
Magnesium Regulation Of Calcium In Essential Hypertension, Elaine Pringle Gordon
Theses and Dissertations in Biomedical Sciences
Essential hypertension is a complex disease which is treated by palliative methods, since the causal factors are as yet unknown. A variety of both genetic and environmental factors probably combine to produce chronic high blood pressure. A genetic model of essential hypertension, spontaneously hypertensive rats (SHR), and its control strain Wistar Kyoto (WKY) were used to investigate a possible environmental causal factor, cellular magnesium deficit, and its impact on the functional ability of the calcium ATPase. Rats were fed either a magnesium-deficient or a magnesium-sufficient diet for 10 weeks, after which the calcium ATPase activity was measured in intact red …