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Full-Text Articles in Life Sciences
Characterization Of A Novel Prostate Tumor-Associated Antigen, Grayson B. Lipford
Characterization Of A Novel Prostate Tumor-Associated Antigen, Grayson B. Lipford
Theses and Dissertations in Biomedical Sciences
The murine monoclonal antibodies (MAb) TURP-27 and HNK-1 have been shown to detect antigens that are heavily expressed by benign prostatic hyperplasia (BPH) and carcinoma of the prostate (CaP). Western blot analysis of prostate extracts, showed that MAb TURP-27 and MAb HNK-1 bound glycoproteins of 180, 140, 120, 100, 90 and 69 kDa. Studies have shown that the HNK-1 carbohydrate epitope may be involved in cell adhesion and that it is a component of several characterized adhesion proteins. TURP-27 was found to bind at least three of these adhesion proteins: neural cell adhesion molecules (N-CAM), myelin-associated glycoprotein (MAG) and a …
Magnesium Regulation Of Calcium In Essential Hypertension, Elaine Pringle Gordon
Magnesium Regulation Of Calcium In Essential Hypertension, Elaine Pringle Gordon
Theses and Dissertations in Biomedical Sciences
Essential hypertension is a complex disease which is treated by palliative methods, since the causal factors are as yet unknown. A variety of both genetic and environmental factors probably combine to produce chronic high blood pressure. A genetic model of essential hypertension, spontaneously hypertensive rats (SHR), and its control strain Wistar Kyoto (WKY) were used to investigate a possible environmental causal factor, cellular magnesium deficit, and its impact on the functional ability of the calcium ATPase. Rats were fed either a magnesium-deficient or a magnesium-sufficient diet for 10 weeks, after which the calcium ATPase activity was measured in intact red …
A Genetic And Physiological Study Of The Role Of Extracellular Copper-Binding Proteins In Copper Detoxification By The Marine Bacterium Vibrio Alginolyticus, Valerie J. Harwood
A Genetic And Physiological Study Of The Role Of Extracellular Copper-Binding Proteins In Copper Detoxification By The Marine Bacterium Vibrio Alginolyticus, Valerie J. Harwood
Theses and Dissertations in Biomedical Sciences
Supernatant proteins in Vibrio alginolyticus batch cultures were analyzed by SDS-PAGE before copper was added, 24 and 48 hours after the addition of copper, and in 24 hour control (no Cu) cultures. Two proteins, one 21 kilodalton (kDa) and one 19 kDa, were found to be copper-induced, and were designated copper-binding protein 1 (CuBP1) and CuBP2. CuBP1 and CuBP2 became detectable in supernatants during the Cu-induced lag phase, and increased in concentration over the following 48 hours. Chloramphenicol inhibited production of these proteins. Gel-to-gel variability was implicated as the dominant factor determining whether one or two Cu-induced proteins were detected …