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Reproductive And Metabolic Effects Of Recombinant Equine Leptin On Seasonally Anovulatory Mares, Pamela Boliew Mitcham
Reproductive And Metabolic Effects Of Recombinant Equine Leptin On Seasonally Anovulatory Mares, Pamela Boliew Mitcham
LSU Master's Theses
Mares of poor body condition have low plasma leptin concentrations, while obese mares have the highest concentrations. Leptin is a primary signal of body condition to the brain in other species; therefore, low leptin concentrations in thin mares could contribute to their extended anovulatory period in winter compared to obese mares. The current experiment was designed to determine whether recombinant equine leptin, administered to seasonally anovulatory mares, would induce ovarian activity and ovulation in the winter. Leptin effects on metabolism were also studied. Beginning January 7, leptin-treated mares (n = 9) received daily i.m. injections of 10 mg recombinant equine …