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Full-Text Articles in Life Sciences
Regulation Of Mpcs And Kat8 During Adipogenesis And Nutritional Regulation, Jasmine Burrell
Regulation Of Mpcs And Kat8 During Adipogenesis And Nutritional Regulation, Jasmine Burrell
LSU Doctoral Dissertations
Obesity is a global epidemic characterized by an expansion of adipose tissue. Adipose tissue, composed of adipocytes and a stromal vascular fraction, is an endocrine organ that regulates whole body homeostasis. Obesity leads to the dysregulation of adipocytes and is often associated with increased susceptibility to metabolic diseases such as Type II diabetes mellitus (T2DM). Understanding the mechanisms by which adipocyte function and development are regulated is crucial. Mitochondrial pyruvate carriers (MPCs) are transmembrane proteins that transport pyruvate from the cytosol into the mitochondrial matrix to generate acetyl CoA. Although MPCs have been studied extensively, their roles in adipocytes are …
Characterization Of Porcine Adipose Tissue-Derived Stem Cells, Kellie J. Williams
Characterization Of Porcine Adipose Tissue-Derived Stem Cells, Kellie J. Williams
LSU Doctoral Dissertations
Nuclear transfer (NT) results in low success rates and research has reported problems with the welfare of cloned animals produced. Evidence suggests the use of a less differentiated donor cell, such as a stem cell, may lead to an increase in the efficiency of the NT procedure. Stem cell characteristics must be clearly defined in order to isolate, identify and optimally culture potential donor cells. Stem cell characteristics such as self-renewal and differentiation have not been identified in stem cells from porcine adipose tissue, an easily attainable tissue resource. The phenotypic profile of cell surface proteins and chromosomal stability of …