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The Hyperinsulinemia-Hyperleptinemia Syndrome In Horses: Assessment Of Methods Of Diagnosis And Differential Effects Of Insulin Injection On Glucose, Glucagon And Nonesterified Fatty Acids In Plasma, Thomas Joseph Caltabilota

LSU Master's Theses

Plasma leptin concentrations in horses have been shown to vary widely. However, many factors may perturb these measurements. Previous research has documented a link between hyperinsulinemia and hyperleptinemia in horses. This condition has been speculated to be associated with components of equine metabolic syndrome, such as insulin resistance and laminitis. However, many of the methods accepted in diagnosing these metabolic abnormalities are expensive and often difficult to perform. Thus, the objectives of the experiments in this thesis were 1) to determine if it is possible to differentiate hyperleptinemic horses from normal ones by hormone manipulation with dexamethasone, a glucocorticoid analog; …