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Full-Text Articles in Life Sciences
Hepatotoxic Effect Of Cadmium And Available Therapeutic Options, Tomilola Olaolu, Favour Jibulu, Rotimi Damilare
Hepatotoxic Effect Of Cadmium And Available Therapeutic Options, Tomilola Olaolu, Favour Jibulu, Rotimi Damilare
The Thai Journal of Pharmaceutical Sciences
Hepatoxicity, also known as toxic hepatitis, is a condition, in which the liver becomes inflamed due to exposure to such substances as chemicals, medications, herbal products, or excessive alcohol consumption. Cadmium is a major environmental pollutant from agricultural and industrial sources and has been reported to induce hepatotoxicity. Cadmium can also be found in phosphate fertilizers, detergents, and refined petroleum products as an impurity and used industrially in the production of polyvinyl chloride product stabilizers and the fabrication of nickel-cadmium batteries. Cadmium can be absorbed into the human body through the gastrointestinal tract, respiratory, and dermal routes. Cadmium-induced hepatic damage …
Virgin Coconut Oil Ameliorates Arsenic Hepatorenal Toxicity And No-Mediated Inflammation Through Suppression Of Oxidative Stress In Rats, Ademola C. Famurewa, Ekenechukwu K. Maduagwuna, Chinyere Aloke, Sharon O. Azubuike-Osu, Arunaksharan Narayanankutty
Virgin Coconut Oil Ameliorates Arsenic Hepatorenal Toxicity And No-Mediated Inflammation Through Suppression Of Oxidative Stress In Rats, Ademola C. Famurewa, Ekenechukwu K. Maduagwuna, Chinyere Aloke, Sharon O. Azubuike-Osu, Arunaksharan Narayanankutty
The Thai Journal of Pharmaceutical Sciences
Background: Compelling evidence has implicated oxidative stress as a leading mechanism for arsenic (As)-induced pathologies. We evaluated antioxidant effect of virgin coconut oil (VCO) against arsenic-induced oxidative stress-mediated hepatorenal damage in rats. Methods: Rats were randomly divided into three groups: Control group, as group, and VCO + As group. VCO was orally administered before and along with arsenic (10 mg/kg body weight, orally) for 21 days. Subsequently, serum liver enzymes, albumin (ALB), creatinine, urea, antioxidant enzymes, malondialdehyde, and nitric oxide (NO) level were evaluated. The histology of the tissues was analyzed with standard procedures. Results: Arsenic caused marked increases in …
Evaluation Of Acute Oral Toxicity Of Methanolic Fractions Of Sesbania Grandiflora Linn. Roots In Albino Mice, N. S. Vinay, S. Babitha, R. Nandeesh, S. Paramesh, E. Manjunath, J. P. Geetha, V. P. Veerapur, B. Swetha, H. V. Keerthi Prasanth
Evaluation Of Acute Oral Toxicity Of Methanolic Fractions Of Sesbania Grandiflora Linn. Roots In Albino Mice, N. S. Vinay, S. Babitha, R. Nandeesh, S. Paramesh, E. Manjunath, J. P. Geetha, V. P. Veerapur, B. Swetha, H. V. Keerthi Prasanth
The Thai Journal of Pharmaceutical Sciences
Introduction: Although Sesbania grandiflora Linn. roots have valuable pharmacological effects, the comprehensive awareness about its toxicity potential has been lacking. Objectives: The objectives of the study were to assess the acute oral toxicity of methanolic fraction of S. grandiflora root (MFSGR). Materials and Methods: The female albino mice were divided into two groups (n = 5), one group served as normal control while the other treated with MFSGR (2000 mg/kg, p.o). Both the groups of mice were observed for 14 days for various parameters according to the Organization for Economic Cooperative and Development guidelines 425 TG. Results: Oral administration of …
Toxicity Of Traditional Medicine Trisan. Part 2. Vata And Semha Formulas(พิษของยาแผนโบราณตรีสาร ตอนที่ 2 ตำรับวาตะและเสมหะสมุฏฐาน), Pranee Chavalittumrong, Aimmanas Attawish, Pat Rugsamon, Pranee Chuntapet
Toxicity Of Traditional Medicine Trisan. Part 2. Vata And Semha Formulas(พิษของยาแผนโบราณตรีสาร ตอนที่ 2 ตำรับวาตะและเสมหะสมุฏฐาน), Pranee Chavalittumrong, Aimmanas Attawish, Pat Rugsamon, Pranee Chuntapet
The Thai Journal of Pharmaceutical Sciences
Trisan, a Thai traditional medicine, is composed of three constituents, namely Plumbago indica, Piper sarmentosum and Piper sp. locally called Sa-Karn, at different ratios based on traditional diagnosis of patients. Vata formula of Trisan, used for the e...
Toxicity Of Andrographis Paniculata Wall, Ex Nees(พิษเฉียบพลันและกึ่งเรื้อรังของฟ้าทะลายโจร), นาถฤดี สิทธิสมวงศ์, เจษฎา เพ็งชะตา, ทรงพล ชีวะพัฒน์, เอมมนัส หวังหมัด, พัชรินทร์ รักษามั่น, จรินทร์ จันทรฉายะ, ปรียา สุวรรณคีรี
Toxicity Of Andrographis Paniculata Wall, Ex Nees(พิษเฉียบพลันและกึ่งเรื้อรังของฟ้าทะลายโจร), นาถฤดี สิทธิสมวงศ์, เจษฎา เพ็งชะตา, ทรงพล ชีวะพัฒน์, เอมมนัส หวังหมัด, พัชรินทร์ รักษามั่น, จรินทร์ จันทรฉายะ, ปรียา สุวรรณคีรี
The Thai Journal of Pharmaceutical Sciences
Acute toxicity test of 50% alcoholic extract of Andrographis paniculata Wall, ex Nees. revealed no evidence of toxicity in mice when given 15 gm/kg body weight. LD50 of the extract administered per os and subcutaneous are more than 15 gm/kg and intraperi...