Microarray Analysis Of Aging-Associated Immune System Alterations In The Rostral Ventrolateral Medulla Of F344 Rats, Sivasai Balivada, Chanran K. Ganta, Yongqing Zhang, Hitesh N. Pawar, Richard J. Ortiz, Kevin G. Becker, Arshad M. Khan, Michael J. Kenney
Jun 2017
Microarray Analysis Of Aging-Associated Immune System Alterations In The Rostral Ventrolateral Medulla Of F344 Rats, Sivasai Balivada, Chanran K. Ganta, Yongqing Zhang, Hitesh N. Pawar, Richard J. Ortiz, Kevin G. Becker, Arshad M. Khan, Michael J. Kenney
Arshad M. Khan, Ph.D.
The rostral ventrolateral medulla (RVLM) is an area of the brain stem that contains diverse neural substrates that are involved in systems critical for physiological function. There is evidence that aging affects some neural substrates within the RVLM, although age-related changes in RVLM molecular mechanisms are not well established. The goal of the present study was to characterize the transcriptomic profile of the aging RVLM and to test the hypothesis that aging is associated with altered gene expression in the RVLM, with an emphasis on immune system associated gene transcripts. RVLM tissue punches from young, middle-aged, and aged F344 rats …
66th National Poultry Breeder Roundtable Poster_Jibin Zhang.Pdf, Jibin Zhang, Carl J. Schmidt, Susan J. Lamont
May 2017
66th National Poultry Breeder Roundtable Poster_Jibin Zhang.Pdf, Jibin Zhang, Carl J. Schmidt, Susan J. Lamont
Jibin Zhang
Fast-growing modern broilers are susceptible to cardiac arrhythmia and heart failure. To understand the developmental regulation related to these problems, cardiac gene expression in Illinois and Ross broilers was investigated at 6 and 21 days post hatch (dph) using RNA-seq (n=5-6 for each group). Because Illinois is a legacy broiler line with isometric heart growth, and Ross is a modern broiler line with a negative allometric heart growth, comparison of gene expression between the two lines and the two time points provides an avenue to understand genetic regulation underlying their different cardiac development.
Sequence data were mapped to the Galgal5 …
Transcriptome Analysis Reveals Potential Mechanisms Underlying Differential Heart Development In Fast- And Slow-Growing Broilers Under Heat Stress, Jibin Zhang, Carl J. Schmidt, Susan J. Lamont
Apr 2017
Transcriptome Analysis Reveals Potential Mechanisms Underlying Differential Heart Development In Fast- And Slow-Growing Broilers Under Heat Stress, Jibin Zhang, Carl J. Schmidt, Susan J. Lamont
Jibin Zhang
Background
Modern fast-growing broilers are susceptible to heart failure under heat stress because their relatively small hearts cannot meet increased need of blood pumping. To improve the cardiac tolerance to heat stress in modern broilers through breeding, we need to find the important genes and pathways that contribute to imbalanced cardiac development and frequent occurrence of heat-related heart dysfunction. Two broiler lines – Ross 708 and Illinois – were included in this study as a fast-growing model and a slow-growing model respectively. Each broiler line was separated to two groups at 21 days posthatch. One group was subjected to heat stress …
Pag 2017 Poster _ Jibin Zhang.Pdf, Jibin Zhang, Michael G. Kaiser, Melissa S. Herrmann, Rodrigo A. Gallardo, David A. Bunn, Terra R. Kelly, Jack C. M. Dekkers, Huaijun Zhou, Susan J. Lamont
Jan 2017
Pag 2017 Poster _ Jibin Zhang.Pdf, Jibin Zhang, Michael G. Kaiser, Melissa S. Herrmann, Rodrigo A. Gallardo, David A. Bunn, Terra R. Kelly, Jack C. M. Dekkers, Huaijun Zhou, Susan J. Lamont
Jibin Zhang
Velogenic Newcastle disease virus (NDV) causes global economic losses in the poultry industry. Although proper vaccination does prevent outbreaks of ND, genetic selection for enhanced resistance to NDV offers a complementary approach to disease prevention. Understanding the gene expression changes induced by ND infection will help to elucidate mechanisms of host resistance and susceptibility.
Two distinct and highly inbred chicken lines - Fayoumi and Leghorn - were studied as relatively ND-resistant and susceptible models, respectively. Equal numbers of birds from each line were inoculated with LaSota strain NDV (or saline control) through nasal and ocular routes at 21 days of …
