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Full-Text Articles in Life Sciences
The Two-Faced Nature Of Small Heat Shock Proteins: Amyloid Assembly And The Inhibition Of Fibril Formation. Relevance To Disease States, Heath W. Ecroyd, S Meehan, John A. Carver
The Two-Faced Nature Of Small Heat Shock Proteins: Amyloid Assembly And The Inhibition Of Fibril Formation. Relevance To Disease States, Heath W. Ecroyd, S Meehan, John A. Carver
Heath Ecroyd
The ability of small heat-shock proteins (sHsps) such as alphaB-crystallin to inhibit the amorphous (disordered) aggregation of varied target proteins in a chaperone-like manner has been well described. The mechanistic details of this action are not understood. Amyloid fibril formation is an alternative off-folding pathway that leads to highly ordered beta-sheet-containing aggregates. Amyloid fibril formation is associated with a broad range of protein conformational diseases such as Alzhiemer's, Parkinson's and Huntington's and sHsp expression is elevated in the protein deposits that are characteristic of these disease states. The ability of sHsps to prevent fibril formation has been less well characterised. …
Baseline Characteristics Of Volunteers In The Smart Clinical Trial: Associations Between Habitual Physical Activity And Lifestyle Disease Risk Factors, Qingsheng Zhang, Jane E. O'Shea, Rebecca L. Thorne, Linda C. Tapsell, Marijka Batterham, Karen E. Charlton
Baseline Characteristics Of Volunteers In The Smart Clinical Trial: Associations Between Habitual Physical Activity And Lifestyle Disease Risk Factors, Qingsheng Zhang, Jane E. O'Shea, Rebecca L. Thorne, Linda C. Tapsell, Marijka Batterham, Karen E. Charlton
Dr Marijka Batterham
Physical Activity has been suggested to have favorable effects on various cardiovascular risk factors, and may serve as an intervening variable in life-style intervention studies. We aimed to examine the relationship between habitual physical activity and selected cardiovascular markers at baseline in a sample of overweight women who participated in the SMART clinical trial [ACTRN12608000425392]. A sub-sample of eighty-six overweight/obese women (mean age ± S.D.: 45 ± 7.9 years) were included in this analysis. Anthropometric and fasting blood data was collected at baseline (t = 0). Habitual physical activity was assessed by a validated questionnaire (Baecke questionnaire). Associations were examined …
Targeting C-Reactive Protein For The Treatment Of Cardiovascular Disease, Mark B. Pepys, Gideon M. Hirschfield, Glenys A. Tennent, J Ruth Gallimore, Melvyn C. Kahan, Vittorio Bellotti, Philip N. Hawkins, Rebecca M. Myers, Martin D. Smith, Alessandra Polara, Alexander J. A Cobb, Steven V. Ley, J. Andrew Aquilina, Carol V. Robinson, Isam Sharif, Gillian A. Gray, Caroline A. Sabin, Michelle C. Jenvey, Simon E. Kolstoe, Darren Thompson, Stephen P. Wood
Targeting C-Reactive Protein For The Treatment Of Cardiovascular Disease, Mark B. Pepys, Gideon M. Hirschfield, Glenys A. Tennent, J Ruth Gallimore, Melvyn C. Kahan, Vittorio Bellotti, Philip N. Hawkins, Rebecca M. Myers, Martin D. Smith, Alessandra Polara, Alexander J. A Cobb, Steven V. Ley, J. Andrew Aquilina, Carol V. Robinson, Isam Sharif, Gillian A. Gray, Caroline A. Sabin, Michelle C. Jenvey, Simon E. Kolstoe, Darren Thompson, Stephen P. Wood
J. A. Aquilina
Complement-mediated inflammation exacerbates the tissue injury of ischaemic necrosis in heart attacks and strokes, the most common causes of death in developed countries. Large infarct size increases immediate morbidity and mortality and, in survivors of the acute event, larger non-functional scars adversely affect long-term prognosis. There is thus an important unmet medical need for new cardioprotective and neuroprotective treatments. We have previously shown that human C-reactive protein (CRP), the classical acute-phase protein that binds to ligands exposed in damaged tissue and then activates complement1, increases myocardial and cerebral infarct size in rats subjected to coronary or cerebral artery ligation, respectively2,3. …
Short Term Effects Of Energy Restriction And Dietary Fat Sub-Type On Weight Loss And Disease Risk Factors, Linda C. Tapsell, Marijka Batterham, Xu-Feng Huang, Sze Yen Tan, Grigorijs Teuss, Karen E. Charlton, Jane E. O'Shea, Eva M. Warensjo
Short Term Effects Of Energy Restriction And Dietary Fat Sub-Type On Weight Loss And Disease Risk Factors, Linda C. Tapsell, Marijka Batterham, Xu-Feng Huang, Sze Yen Tan, Grigorijs Teuss, Karen E. Charlton, Jane E. O'Shea, Eva M. Warensjo
Xu-Feng Huang
Background and aims: Decreasing energy intake relative to energy expenditure is the indisputable tenet of weight loss. In addition to caloric restriction modification of the type of dietary fat may provide further benefits. The aim of the present study was to examine the effect of energy restriction alone and with dietary fat modification on weight loss and adiposity, as well as on risk factors for obesity related disease. Methods and results: One-hundred and fifty overweight men and women were randomized into a 3 month controlled trial with four low fat (30% energy) dietary arms: (1) isocaloric (LF); (2) isocaloric with …
Ec00-1207 Growing Onions, Shallots, And Chives, Susan Schoneweis, Laurie Hodges, Loren J. Giesler
Ec00-1207 Growing Onions, Shallots, And Chives, Susan Schoneweis, Laurie Hodges, Loren J. Giesler
Laurie Hodges
The common onion (Allium cepa) is the most popular and widely grown Allium in Nebraska home gardens. Many members of the onion family (Alliaceae) are used in flower gardens because of their interesting flowers and foliage, but here we're going to focus on the onion as a vegetable crop. This publication will discuss the different types of onions and how to grow onions from onion sets, plants, transplants, and seed. It will cover the different cultivars found here in Nebraska, the nutrition, fertilizing, harvesting, curing and storing of onions.
Nf92-69 Selected Vegetable Cultivars For Nebraska, Susan Schoneweis, Laurie Hodges
Nf92-69 Selected Vegetable Cultivars For Nebraska, Susan Schoneweis, Laurie Hodges
Laurie Hodges
This NebFact provides information about cultivars of garden vegetables available to grow in Nebraska.
Ec81-1240 Vegetable Gardening In Nebraska, Dale T. Lindgren, Laurie Hodges, Don Steinegger, Ralph E. Neild
Ec81-1240 Vegetable Gardening In Nebraska, Dale T. Lindgren, Laurie Hodges, Don Steinegger, Ralph E. Neild
Laurie Hodges
Nebraskans are increasing their consumption of fresh vegetables — as appetizers, salads, side dishes, and snacks. Fresh vegetables are an integral part of a healthy, well-balanced diet. Although Nebraska's climate and soil are well-suited for many vegetables, most are supplied from out of the state, even during summer. Growing fresh vegetables can provide higher nutrition and flavor at less expense than buying fresh produce at the grocery store. A garden also can be a source of personal enjoyment and satisfaction. This extension circular helps the gardener decide when, where, and how to plant and maintain a vegetable garden.
A Case Study To Teach The Diagnostic Process: Determining The Cause Of Chlorosis In A Crop Of Cut Dicentra, Marci Spaw, Kimberley A. Williams, Laurie Hodges, Ellen T. Paparozzi, Ingrid L. Mallberg
A Case Study To Teach The Diagnostic Process: Determining The Cause Of Chlorosis In A Crop Of Cut Dicentra, Marci Spaw, Kimberley A. Williams, Laurie Hodges, Ellen T. Paparozzi, Ingrid L. Mallberg
Laurie Hodges
This universally accessible, Web-based decision case presents the challenge of determining the cause of foliar chlorosis in a crop of dicentra (Dicentra spectabilis) being forced as a cut flower for Valentine's Day sales. The case study serves as a tool to promote the development of diagnostic skills for production dilemmas, including nutritional disorders, disease problems, and evaluation of the appropriateness of cultural practices, Cut dicentra is a minor crop and standard production practices are not well established. Solving this case requires that students research production protocol, as well as nutritional and pest problems, and determine whether they have enough information …
Genetic Adult Lactase Persistence Is Associated With Risk Of Crohn's Disease In A New Zealand Population, Deborah Nolan, Dug Yeo Han, Wen Jiun Lam, Angharad R. Morgan, Alan G. Fraser, Linda C. Tapsell, Lynnette R. Ferguson
Genetic Adult Lactase Persistence Is Associated With Risk Of Crohn's Disease In A New Zealand Population, Deborah Nolan, Dug Yeo Han, Wen Jiun Lam, Angharad R. Morgan, Alan G. Fraser, Linda C. Tapsell, Lynnette R. Ferguson
L. C. Tapsell
Background Mycobacterium avium subspecies paratuberculosis (MAP) is an infective agent found in ruminants and milk products, which has been suggested to increase the risk of gastrointestinal inflammation in genetically susceptible hosts. It is hypothesized that lactase persistence facilitates exposure to such milk products increasing the likelihood of adverse outcomes. Individuals either homozygous or heterozygous for the T allele of DNA variant, rs4988235, located 14kb upstream from the LCT locus, are associated with having lactase persistence. The aim of this study was to determine whether lactase persistence as evident by the T allele of rs4988235 is associated with Crohn’s Disease (CD) …
Industry Partnerships For Health Nonprofits And Disease Awareness Advertising, Danika Hall, Sandra C. Jones, Donald C. Iverson
Industry Partnerships For Health Nonprofits And Disease Awareness Advertising, Danika Hall, Sandra C. Jones, Donald C. Iverson
Don C. Iverson
Marketing partnerships between non-profit organisations (NPOs) and industry generally bring favourable results for both parties (Brønn and Vrioni 2001; Varadarajan and Menon 1988). However, there is some scepticism about corporate exploitation of such arrangements and growing concern in Australia and elsewhere about partnerships between the pharmaceutical industry and NPOs (Angell 2006; Moynihan and Cassels 2005) and the co-sponsorship of Disease Awareness Advertising (DAA). This paper reports the findings from a study of how Australian women respond to DAA with differing sponsors including their ability to identify, and their attitude toward, the sponsor. The results are of importance for health NPOs …
Disease Awareness Advertisements In Australian Magazines: An Analysis Of Content And Compliance, Danika Hall, Sandra C. Jones, Donald C. Iverson
Disease Awareness Advertisements In Australian Magazines: An Analysis Of Content And Compliance, Danika Hall, Sandra C. Jones, Donald C. Iverson
Don C. Iverson
In Australia, Direct to Consumer Advertising (DTCA) of prescription medicine is prohibited; however pharmaceutical companies can communicate directly with consumers via Disease Awareness Advertising (DAA). DAA can contain information about a disease including treatment information, but cannot mention the name of a particular product or brand. DAA is currently regulated by the industry body Medicines Australia (MA). In the current study, content analysis methodology was used to determine the extent and nature of DAA in popular Australian women’s magazines which were monitored for 12 months. Findings relating to the use of visual appeals in the imagery and rational appeals in …
Disease Awareness Advertising: Women's Intentions Following Exposure, Danika Hall, Sandra C. Jones, Donald C. Iverson
Disease Awareness Advertising: Women's Intentions Following Exposure, Danika Hall, Sandra C. Jones, Donald C. Iverson
Don C. Iverson
Background: In Australia, where direct to consumer advertising of prescription medicines is prohibited, pharmaceutical companies can sponsor disease awareness advertising targeting consumers. This study examined the impact of disease awareness advertising exposure on older women's reported behavioural intentions. Method: Women were approached in a shopping centre and randomly assigned mock advertisements for two health conditions. Disease information and sponsors were manipulated. Results: Two hundred and forty-one women responded to 466 advertisements. Almost half reported an intention to ask their doctor for a prescription or referral as a result of seeing the advertisement, but more reported they would talk to their …
Content Analysis Of Disease Awareness Advertisements In Popular Australian Women's Magazines, Danika V. Hall, Sandra C. Jones, Donald C. Iverson
Content Analysis Of Disease Awareness Advertisements In Popular Australian Women's Magazines, Danika V. Hall, Sandra C. Jones, Donald C. Iverson
Don C. Iverson
Objective: To examine the nature of disease awareness advertising (DAA). Design: Therapeutic advertisements in six popular Australian women’s magazines were monitored between April 2006 and March 2007. A subset of advertisements was included in the study based on criteria derived from a definition of DAA. Unique advertisements were analysed by four independent coders. Main outcome measures: Types of advertisements and their sponsors, the types of disease information present, and the persuasive techniques utilised. Results: Of 711 advertisements identified, 60 met the inclusion criteria for DAA, and 30 of these were unique. Over one-third of the advertisements were classified as “unbranded …
Ec96-142 Crp Land Use Guide (Conservation Reserve Program), Douglas Anderson
Ec96-142 Crp Land Use Guide (Conservation Reserve Program), Douglas Anderson
Douglas Anderson
Conservation Reserve Program (CRP) contracts held by Nebraska producers will begin to expire in 1996. Thousands of acres of grassland will be eligible for haying, grazing or to be returned to other uses. Land-use decisions made by owners and operators will impact the economic viability and long-term productivity of individual farms, as well as the region as a whole. The intent of the CRP Land Use Guide is not to provide all the asnwers - in many instances we don't even know the questions. It is however, intended to provide an outline of the key issues you will face when …