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Highly Iterated Palindromic Sequences (Hips) And Their Relationship To Dna Methyltransferases, Jeff Elhai
Highly Iterated Palindromic Sequences (Hips) And Their Relationship To Dna Methyltransferases, Jeff Elhai
Study of Biological Complexity Publications
The sequence GCGATCGC (Highly Iterated Palindrome, HIP1) is commonly found in high frequency in cyanobacterial genomes. An important clue to its function may be the presence of two orphan DNA methyltransferases that recognize internal sequences GATC and CGATCG. An examination of genomes from 97 cyanobacteria, both free-living and obligate symbionts, showed that there are exceptional cases in which HIP1 is at a low frequency or nearly absent. In some of these cases, it appears to have been replaced by a different GC-rich palindromic sequence, alternate HIPs. When HIP1 is at a high frequency, GATC- and CGATCG-specific methyltransferases are generally present …