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Full-Text Articles in Life Sciences
Life-Centered Ethics And The Human Future In Space, Michael Noah Mautner
Life-Centered Ethics And The Human Future In Space, Michael Noah Mautner
Chemistry Publications
In the future, human destiny may depend on our ethics. In particular, biotechnology and expansion in space can transform life, raising profound questions. Guidance may be found in Life-centered ethics, as biotic ethics that value the basic patterns of organic gene/protein life, and as panbiotic ethics that always seek to expand life. These life-centered principles can be based on scientific insights into the unique place of life in nature, and the biological unity of all life. Belonging to life then implies a human purpose: to safeguard and propagate life. Expansion in space will advance this purpose but will also raise …
A Robust Approach To Identifying Tissue-Specific Gene Expression Regulatory Variants Using Personalized Human Induced Pluripotent Stem Cells, Je-Hyuk Lee, In-Hyun Park, Yuan Gao, Jin B. Li, Zhe Li, George Q. Daley, Kun Zhang, George M. Church
A Robust Approach To Identifying Tissue-Specific Gene Expression Regulatory Variants Using Personalized Human Induced Pluripotent Stem Cells, Je-Hyuk Lee, In-Hyun Park, Yuan Gao, Jin B. Li, Zhe Li, George Q. Daley, Kun Zhang, George M. Church
Study of Biological Complexity Publications
Normal variation in gene expression due to regulatory polymorphisms is often masked by biological and experimental noise. In addition, some regulatory polymorphisms may become apparent only in specific tissues. We derived human induced pluripotent stem (iPS) cells from adult skin primary fibroblasts and attempted to detect tissue-specific cis-regulatory variants using in vitro cell differentiation. We used padlock probes and high-throughput sequencing for digital RNA allelotyping and measured allele-specific gene expression in primary fibroblasts, lymphoblastoid cells, iPS cells, and their differentiated derivatives. We show that allele-specific expression is both cell type and genotype-dependent, but the majority of detectable allele-specific expression …