Life Sciences Commons^™

Western Science And Eastern Zen To Seek The Origin Of Truth: Philosophical Background Of Scale Modeling, Kozo Saito

Progress in Scale Modeling, an International Journal

This article was written to introduce philosophical background of scale modeling, where Zen philosophy was applied to overcome the limitation of logical thinking and hypotheses-driven deductive science. Three specific reasons are as follows. The first is related to the law approach in scale modeling; it uses the kufu principle, originated in Zen Buddhism, together with the other three scientific methods: experimental, theoretical, and computational. The second reason is because scale modeling seeks relativistic understanding by attempting to realize similarity; the concept is closer to Eastern philosophy rather than absolute understanding cultivated by deductive science. The third is in the educational …

Harmonious Healing: A Review Of Music Therapy, A Humanities-Based Approach To Alzheimer’S Disease Treatment, Rohan K. Desai

Kentucky Undergraduate Journal for the Health Humanities

Alzheimer’s Disease (AD) is a progressive neurodegenerative disease often characterized by memory loss, confusion, and overall cognitive decline. The aging global population has, in recent years, highlighted the fundamental lack of pharmacological treatments for individuals facing an AD diagnosis. In response, a growing body of research has shifted focus to non-pharmacological humanities-based interventions. One such intervention has been music therapy (MT). Music-focused measures have shown great promise as a method of slowing cognitive decline, but mixed results in the literature warrant the need for further investigation. Often, socioeconomic barriers can limit an individual’s access to drug-related treatments, but the affordable …

Tricritical Point As A Crossover Between Type-Is And Type-Iis Bifurcations, Prabakaran Rajamanickam, Joel Daou

Progress in Scale Modeling, an International Journal

A tricritical point as a crossover between (stationary finite-wavelength) type-I_s and (stationary longwave) type-II_s bifurcations is identified in the study of diffusive-thermal (Turing) instability of flames propagating in a Hele-Shaw channel in a direction transverse to a shear flow. Three regimes exhibiting different scaling laws are identified in the neighbourhood of the tricritical point. For these three regimes, sixth-order partial differential equations are obtained governing the weakly nonlinear evolution of unstable solutions near the onset of instability. These sixth-order PDES may be regarded as the substitute for the classical fourth-order Kuramoto­­­­­­–­­Sivashinsky equation which is not applicable near the …

Self-Reported Consumption Of Bottled Water V. Tap Water In Appalachian And Non-Appalachian Kentucky, Jason W. Marion

Journal of Appalachian Health

Introduction: Quantitative studies on drinking water perceptions in Appalachia are limited. High-profile water infrastructure failures in the U.S. and Eastern Kentucky, coupled with human-made and natural disasters in the Appalachian Region, have likely impacted opinions regarding tap water.

Purpose: To use existing unexplored data to describe baseline tap water v. bottled water consumption in Kentucky.

Methods: Telephone-based cross-sectional data were obtained from the 2013 Kentucky Health Issues Poll (KHIP) directed by the Foundation for a Healthy Kentucky. Among many items in KHIP, self-reported consumption of bottled water over tap water, reasons for bottled water use, and demographic data were obtained. …

Scale Model Experiments Of Toxic Gas Production From The Combustion Of Polymers When Applied With Different Droplet Sizes Of Water Mist, Nicharee Thinnakornsutubutr, Masayuki Mizuno, Kazunori Kuwana

Progress in Scale Modeling, an International Journal

This research experimentally investigated the combustion of polymeric materials with water mist application in an enclosure, with an emphasis on the production of toxic gases. Two different diameters, ~100 and ~260 μm, were tested. The experimental conditions were determined based on Froude similarity laws for low drop Reynolds number conditions. Droplets and polymers’ physical and chemical properties influence the burning/extinguishing behavior and toxic-gas evolution. In general, larger droplets can extinguish a fire in a shorter time, and toxic gas concentrations in a test chamber decreased more rapidly. However, the large droplets tended to cause the flame expansion phenomenon for thermoplastics …

Validation Of Monitoring Septic Thymus Involution In Mice Using Ultrasound., Jianyao Xue, Xiang-An Li

Journal of Pharmacology & Nutritional Sciences

Sepsis is a dangerous condition commonly seen in the intensive care unit (ICU) of hospitals. It causes the thymus, a crucial immune organ, to shrink. This process is known as thymus involution. Although thymus involution is a natural process that occurs as we age, it is accelerated during sepsis. This process is associated with poor outcomes in septic patients, yet it had never been studied using ultrasonography in a septic mouse model. Researchers from the University of Kentucky have validated a non-invasive ultrasound imaging approach to monitor septic thymus involution in a cecum ligation and puncture (CLP) sepsis mouse model. …

The Last Of Us In Therapy: How Mind-Controlling Fungi And Gut Bacteria Affect Your Mental Health, Anastasia Lyon

Journal of Pharmacology & Nutritional Sciences

The "psilocybiome" represents the mutually beneficial relationship between ourselves, our bacteria, and psychedelic drugs. This short review briefly discusses the benefits and limitations surrounding the potential for psychedelic therapy to synergize with gut bacteria to help regulate and maintain proper balance in the immune system, diet, and stress levels. Psychedelic therapy is a novel treatment strategy that has the potential to improve patient mental health, and, by identifying the types of gut bacteria present in patients, it can aid in personalizing medicine by determining how well their "psilocybiome" may respond.

(Pro)Renin Receptor And Its Soluble Form In Metabolic Dysfunction: Friend Or Foe?, Gertrude Arthur

Journal of Pharmacology & Nutritional Sciences

(Pro)renin receptor is component of the renin angiotensin system which has been shown to be involved in several physiological and pathophysiological processes including blood pressure regulation and hypertension, water and electrolyte balance, kidney injury, obesity, and metabolic dysfunction. Enzymatic cleavage of prorenin receptor produces soluble prorenin receptor which can also activate the renin angiotensin system stimulate similar pathophysiological process like its full form receptor. This review explores findings on the role of prorenin receptor and soluble prorenin receptor in metabolic dysfunction and discusses the conflicting findings on soluble prorenin receptor in metabolic dysfunction.

Nutritional & Colorectal Health, Tariq A. Alam, Brittany R. Rice, Sara B. Police

Journal of Pharmacology & Nutritional Sciences

Kentucky has the highest incidence and mortality rate of all site cancers, and Kentuckians residing in the Appalachian region often have worse outcomes, where cancer is a leading cause of death. Focusing on colorectal cancer (CRC) specifically, Kentucky ranks first nationwide for incidence (50 cases per 100,000 people) and fifth for mortality (about 17 deaths per 100,000 people). The Kentucky Colon Cancer Screening Program increased screening rates and reduced mortality since its launch. Yet, CRC remains a leading cause of death for Kentuckians. Risk factors for CRC include increasing age as well as a history of inflammatory bowel disease (IBD) …

A Simplified Model For The Intermediate Structure Of Strong Fire Whirls, Forman A. Williams

Progress in Scale Modeling, an International Journal

A model is described for the overall structure of intense fire whirls, based on a spatially evolving vortex, with circulation enhancement driven by the axial acceleration of low-density gas in the core through the axial pressure gradient. The axial acceleration increases the entrainment rate into the core which, through mass conservation, increases the circulation if the angle between the tangential and radial velocity components remains fixed. The two-zone model employs general balance equations for regions inside and outside a cylinder of fixed radius, each inviscid, the inside region being presumed to have a constant density small compared with the (constant) …

Reduced-Scale Experiments And Numerical Simulations Of Informal Settlement Dwelling Fires, Vigneshwaran Narayanan, Antonio Cicicone, Ayden D. Botha, Richard Shaun Walls

Progress in Scale Modeling, an International Journal

Informal settlement dwellings (ISDs) house approximately one billion people in the developing world and this number is expected to double by the year 2030. Contemporary research on ISD fires has focused on understanding the fire dynamics within individual dwellings (micro-scale) and fire spread in settlements consisting of multiple dwellings (macro-scale). This paper aims to do two primary things: investigate if scaling methods that were derived for compartments with thermally thick boundaries can be applied to ISDs (compartments with thermally thin boundaries), and if they can adequately represent the most important phenomena associated with full-scale ISD fires; and demonstrate Fire Dynamics …

Open-Field Scale-Model Experiments Of Fire Whirls Over L-Shaped Line Fires, Yuto Iga, Kazunori Kuwana, Kozo Sekimoto, Yuji Nakamura

Progress in Scale Modeling, an International Journal

This paper presents the results of open-field scale-model experiments of fire-whirl formation over line fires. L-shaped line fires were burned in crosswinds, and the processes of fire-whirl formation were observed. The flame height was measured using an image-processing technique, while two-dimensional velocity components were measured at two different locations using ultrasonic anemometers. Two tests were selected for comparison: test A, in which intense fire whirls repeatedly formed, and test B, in which no whirls were observed. In test A, the wind flow was bent by the fire plume, creating swirling flows near the burning area, thereby forming fire whirls. On …

Effect Of Reduced Plume Entrainment On The Burning Rate Of Porous Fuel Beds, Sara Mcallister

Progress in Scale Modeling, an International Journal

Large outdoor fires often exhibit unexpected fire behavior, particularly compared with much smaller fires. Understanding the difference between large- and small-scale fires is of importance for both fire behavior predictions and safety. Large fires are often characterized by very tall plumes that can extend to the stratosphere. Particularly as the actively burning area increases, plumes in large-scale fires likely entrain relatively little and may act in a similar fashion to a chimney. To explore the possible changes in burning rate due to the chimney effect, experiments were conducted with wood cribs burned with a chimney of variable height. The burning …

Scale Model Test To Estimate Thermal Damage By Fire In Aircraft Cargo, Jian Gao, Tsuneyoshi Matsuoka, Yuji Nakamura

Progress in Scale Modeling, an International Journal

The Federal Aviation Administration (FAA) requires fire detectors to alarm within one minute of the start of a fire in cargo compartments of airplanes. To determine whether such alarm timing works, investigations of the thermal damage to ceilings and other structures during the early stage of a fire were accomplished to demonstrate compliance with these FAA regulations. The objective was to test the feasibility of predicting convective heat transfer in early stage of a cargo compartment fire by conducting reduced scale (lab scale) experiments. First, the scaling laws was derived and validated. Then, full-scale and half-scale experiments were performed with …

Extinguishment Of Diffusion Flames Formed Over A Porous Plate Burner Using Rubber Balloons Filled With Inert Gases, Hiroyuki Torikai, Shinya Kudo

Progress in Scale Modeling, an International Journal

We have proposed an inert gas, rubber-balloon extinguishing method which might increase the effectiveness of extinguishing flames and decreasing the amounts of agents needed for fire suppression. Hence, extinguishing experiments have been performed to further clarify possible extinguishing characteristics, mechanisms and scaling effects of this method. Carbon dioxide, nitrogen, argon and helium gases were used as the extinguishing agents. Methane-air and propane-air diffusion flames were formed on two different diameter, round porous plate burner and used as the targets for extinguishment. The extinguishing probabilities were measured, and the extinguishing processes were observed with a high-speed camera. As a result, an …

Effects Of Dimensionless Numbers On Decomposition Of Methane Hydrate, Shoma Shimizu, Genichiro Kushida

Progress in Scale Modeling, an International Journal

It is necessary to elucidate the decomposition and combustion of methane hydrate for fire safety during transportation and storage to utilize it for commercial practice. The amount of methane evolved during the decomposition of methane hydrates is affected by the conditions such as the initial temperature, initial density and ambient temperature. In the present study, the internal temperature of methane hydrate and the amount of methane evolved during its decomposition were investigated by a dimensionless numerical analysis using a transient one-dimensional conduction model from a symmetrical methane hydrate ball heated by ambient air. The numerically calculated central temperature and the …

A Study On Fire Hazards Of Oil Tanks In Urban Areas With Scale Model Experiments, Ho Yin Ng, Yu Wan, Wan Ki Chow

Progress in Scale Modeling, an International Journal

Large fuel tanks are located in an urban area of Tsing Yi in Hong Kong, giving potentially high risks to people living nearby if a fire was to occur. Scale modeling experiments were carried out to investigate the potential of fire hazards. Propanol pool fires with five different scales of oil tanks were studied first. Appropriate tank sizes were then put in a 1/2500 architectural scale model on the Tsing Yi Island to study a fuel tank fire. Results show that the heat and smoke from a fire would affect occupants staying in areas near to the fuel tanks. Fire …

Fingering Behavior Of Flame Spread Over Solid Combustibles, Tsuneyoshi Matsuoka, Kentaro Nakashima, Takuma Kajimoto, Akihiro Yoshimasa, Yuji Nakamura

Progress in Scale Modeling, an International Journal

In this study, the fingering pattern formation and the following flamelet spreading over three different kinds of thick combustibles, i.e., Poly methacrylate (PMMA), Poly ethylene (PE) and Poly carbonate (PC) were observed and the effective Lewis number correlation was validated. Experiments were performed with a narrow channel apparatus. In addition to the kinds of solid fuel materials, the channel height and the oxidizer velocity were varied as experimental parameters. An image analysis method was developed to quantify the number, diameter and spread rate of the flamelets. Replacing the fuel thickness into the thermal thickness, the effective Lewis number which is …

Data-Driven Tools Guided By First-Principles For Scale Modeling, Sadegh Poozesh

Progress in Scale Modeling, an International Journal

For decades, traditional scale-modeling techniques have been relying on first-principles models (FPMs). FPMs have been used to find non-dimensional numbers (PIs) and identify normalized underlying forces and energies behind the phenomenon in focus. The two main challenges with FPM-based PIs extraction are finding the relevant PIs and proper correlations between PIs. The emergence and surge of data-driven modeling (DDM) provide a new opportunity to leverage experimental data in model development across scales/plants. In this paper, first, the two mentioned issues in PIs development will be elaborated to reveal the gap, and second, a new insight into scale modeling and similarity …

Qualitative Analysis Of Maternal Barriers And Perceptions To Participation In A Federal Supplemental Nutrition Program In Rural Appalachian North Carolina, Sydeena E. Isaacs, Lenka H. Shriver, Lauren Haldeman

Journal of Appalachian Health

Background: Little is known about barriers to and perceptions of participation in the in Women, Infants, and Children (WIC) program in rural Appalachia.

Purpose: To gain a deeper understanding of maternal barriers and perceptions related to WIC participation in rural Appalachia

Methods: Pregnant women and mothers were recruited in-person and via flyers from WIC offices in three counties in Appalachian North Carolina. Four semi-structured focus groups were conducted between May to July 2018. Each focus group was approximately 60 minutes long and included open-ended questions about the overall WIC experience in rural Appalachia. Focus groups were audio-recorded, transcribed verbatim, and …

A Strategy To Predict The Global Warming Gas From Stock Farming —Potential Scaling Law Of The Released Methane From Livestock—, Toshiaki Nakashima, Tsuneyoshi Matsuoka, Yuji Nakamura

Progress in Scale Modeling, an International Journal

This work examines a scaling approach to predict the amount of methane released from the daily activity of livestock on farms. The subject animals are ruminants, i.e. having rumen or a ruminant stomach, that generates methane through digestion processes via several microbial fermentation steps. The produced methane is mixed into their breathing and released into the atmosphere. Existing data on methane released from various kinds of ruminant livestock were correlated as a power function of an animal’s weight, with an exponent near 0.92. This value is larger than a value of 0.75 which was related to the general metabolism rates …

The Behavior Of Micro Explosive Charge Underwater Explosion Near A Rigid Wall, Kazutaka Kitagawa, Atsushi Abe

Progress in Scale Modeling, an International Journal

The interactions between an underwater explosion and underwater structures is a research topic related to understanding strong impulsive forces for disaster preparation and prevention. This study is a part of series studying the behavior of underwater explosion bubbles near different boundaries and structures because understanding the boundary phases and the pulsation of bubbles could be a useful predictive tool. Micro explosive underwater explosions were conducted by detonating a very small amount of silver azide; the time evolution and attenuation of effects from the explosion were studied. Both numerical and experimental data were acquired and compared for underwater shock waves, gas …

Consumption Of Added Sugars By Rural Residents Of Southwest Virginia, Maryam Yuhas, Valisa Hedrick, Jamie Zoellner

Journal of Appalachian Health

Introduction: Nationally, rural residents have high consumption of added sugars, yet the top sources have not been explored. Characterizing added-sugar intake in high sugar-sweetened beverage (SSB) consumers in rural areas is an important step to help inform interventions and policies.

Purpose: The objective of this study was to explore the top food and beverage sources of added sugar and to examine variations by sociodemographic characteristics.

Methods: This cross-sectional study analyzed data from a randomized-controlled trial to reduce SSB in eight rural Appalachian counties. Data were obtained from baseline demographic surveys and three 24-hour dietary recalls. Dietary analyses included deriving AS …

A Nutritional And Environmental Analysis Of Local Food Pantries Accessible To College Students In Rural North Carolina, Emily E. Frymark, Jonathon Stickford, Alisha Farris

Journal of Appalachian Health

Introduction: Food insecurity is a growing concern among college students and is especially prevalent in rural areas. Food pantries often serve as a resource to food insecure individuals yet, their policies, standards, and nutritional quality vary due to the unpredictability of food donations.

Purpose: To examine the nutritional quality of food items and adherence of best practices at local food pantries accessible to college students near a university in rural Appalachia.

Methods: Three food pantries in North Carolina were selected due to their proximity to a local, rural university. Food items were analyzed for nutrient and food …

Appalachian Environmental Health Literacy: Building Knowledge And Skills To Protect Health, Anna G. Hoover, Annie Koempel, W. Jay Christian, Kimberly I. Tumlin, Kelly G. Pennell, Steven Evans, Malissa Mcalister, Lindell E. Ormsbee, Dawn Brewer

Journal of Appalachian Health

Environmental health literacy (EHL) is an emerging, multidisciplinary field that promotes understanding of how environmental exposures can affect human health. After discussing the regional relevance of environmental health knowledge and skills, this article describes three ongoing Appalachian projects that are focused on measuring and building EHL.

Why We Can’T Solve The Opioid Problem, Wayne F. Coombs, Ph.D.

Journal of Appalachian Health

Appalachia’s opioid epidemic is a complex, systemic problem being addressed by limited intervention processes conceptualized through narrow disciplinary models that are not working. We need a new comprehensive, collaborative approach if we ever hope to find solutions to this problem.

Incidence Of West Nile Virus In House Sparrow Nestlings In Relation To Parental Effort, Natalie Mickelsen

Kaleidoscope

The house sparrow, Passer domesticus, is known to be an important host of West Nile (WN) virus and may contribute to the transmission of WN virus to humans. However, little is known about the factors that influence the occurrence of WN virus in birds. I conducted a study to determine if parental care was related to the rates of WN virus infections among nestling birds. I observed house sparrow nests for one hour periods noting the time the male and female parent spent on the nest box, in the nest box, and the number of food trips, as measures …

Workforce Fitness: Description, Contextual Issues, And Implications For Public Health, Nicolaas P. Pronk

Frontiers in Public Health Services and Systems Research

Workforce fitness matters for the prevention of premature death, chronic diseases, productivity loss, excess medical care costs, loss of income or family earnings, and other social and economic concerns. Yet fitness levels appear to be relatively low and declining. Over the past half century obesity has doubled, physical activity levels are below par, and cardiorespiratory fitness often does not meet minimally acceptable job standards. During this time, daily occupational energy expenditure has decreased by more than 100 calories. It is recommended for employers to consider best practices and design workplace wellness programs accordingly. Regulations that protect and promote worker health, …

Development Of Transgenic Lines To Support Plant Cell Biology Research, Kristin Kopperud

Kaleidoscope

Viruses pose a threat to humans in a variety of ways — from direct infection to imposing devastating effects on the agriculture industry. Prevention of such infection requires knowledge of the mechanisms of viral infection, both in animal- and plant-infecting species. The goal of this project was to identify plant factors that interact with viral proteins in the course of infection leading to disease. Sonchus yellow net virus (SYNV) and Potato yellow dwarf virus (PYDV) were used to test the hypothesis that the viruses utilize different subsets of host factors in order to infect Nicotiana benthamiana, despite both being …

The Agricultural Footprints On The Environment, Philip Houtz

Kaleidoscope

Industrialized agricultural systems have given America a convenient and affordable means to supply a surplus of food products to its citizens. Transgenic technology, synthesized fertilizers, advanced pesticides, concentrated animal feeding operations (CAFOs), and the use of farm machinery have all contributed to humanity’s ability to feed the world’s rapidly growing population. However, the energy-intensive food operation of today may not be as ideal as we assume. Fossil fuels are burned to meet the energy requirements for the continual production of large quantities of fertilizer and to keep farm machines operational. Fertilizer and pesticide runoff from farmland ultimately drains into rivers …