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Articles 1 - 30 of 1132
Full-Text Articles in Life Sciences
Bio-Bust: Investigating Biotech Stock Factors Contributing To Abnormal Returns In The Wake Of Silicon Valley Bank's Failure, Spencer Kent
Bio-Bust: Investigating Biotech Stock Factors Contributing To Abnormal Returns In The Wake Of Silicon Valley Bank's Failure, Spencer Kent
CMC Senior Theses
Following the unprecedented collapse of Silicon Valley Bank (SVB) in March 2023, this study explores abnormal stock price reactions within the biotechnology sector. As the chosen financial institution for countless Silicon Valley-type technology and healthcare firms, SVB's failure had a profound impact on small to mid-sized biotech companies. Analyzing a dataset of 180 biotech firms during a two-day event window over SVB’s collapse, I investigate whether exposure to SVB, or other factors, was the primary contributor to negative abnormal stock price reactions, considering variables such as the percentage of cash held at SVB, whether a firm maintained an active SVB …
Developmental Stress Signaling And Substance Use: Cortisol Reactivity Moderates The Effect Of Early Life Adversity On Alcohol Misuse Behaviors Among College Students, Keeley Lariviere
CMC Senior Theses
Stress-motivated drinking is common among college students facing increased independence and novel stressors. Early life adversity (ELA) as well as individual variation in neuroendocrine stress signaling significantly increase risk for alcohol misuse. Research on the relationships between ELA and the physiological stress response system, suggest that a dampened stress response may mediate the relations between ELA and alcohol misuse. However, other research has suggested that rather than acting as mediator, stress reactivity may interact (moderate) the relations between ELA and alcohol misuse. This study examined the associations between ELA, cortisol reactivity to an acute stressor, and self-reported alcohol misuse in …
C. Compactum Acts As A Comprehensive Climate Archive And Ecological Foundation In The Labrador Sea, Sadie Heckman
C. Compactum Acts As A Comprehensive Climate Archive And Ecological Foundation In The Labrador Sea, Sadie Heckman
CMC Senior Theses
Clathromorphum compactum, a species of crustose coralline algae (CCA), is incredibly valuable for the future of high latitude ocean health, both as a comprehensive archive of changing ocean conditions, and ecologically as a foundational species for promoting biodiversity. Previous work establishes C. compactum as an effective climate proxy, and its life history provides several advantages for this use. C. compactum grow in nongeniculate, generally radial formations on hard substrates, over a wide distribution in mid-to-high latitude oceans and at subtidal depth ranges. Indeterminate growth leads to extreme longevity in C. compactum (Halfar et al., 2008), and growth rates are relatively …
Harnessing Antagonistic Pleiotropy: Tolc-Dependent Coliphages Can Drive Reduced Antibiotic Resistance In E. Coli, Cooper Mckenna
Harnessing Antagonistic Pleiotropy: Tolc-Dependent Coliphages Can Drive Reduced Antibiotic Resistance In E. Coli, Cooper Mckenna
CMC Senior Theses
The rise of multidrug-resistant (MDR) bacterial pathogens has been a growing concern in healthcare around the world, and bacteriophage (phage) therapy is a promising method to combat MDR infections. One defense mechanism of E. coli against antibiotics is the TolC-AcrAB efflux pump. At the same time, some phages use TolC as a surface receptor to infect the cell. This puts TolC at a crossroads in which it is beneficial to the bacteria to protect against antibiotics but harmful by allowing phage infection, creating the potential for evolutionary trade-offs. Previous research has identified only three TolC-dependent phages and shown phage-resistant E. …
What Are We Most Curious About? Understanding The Relationship Between Curiosity And Marginal Knowledge, Alexis Lee
What Are We Most Curious About? Understanding The Relationship Between Curiosity And Marginal Knowledge, Alexis Lee
CMC Senior Theses
There are several competing theories about the relationship between curiosity and metacognitive judgment, or one’s assessment of their own knowledge. Novelty theories say that curiosity is highest for wholly unknown information; complexity theories say that curiosity is highest for moderately unknown information; and the Region of Proximal Learning (RPL) theory says that curiosity is highest for almost-known information. The present study aimed to address how curiosity differs within marginal knowledge (MK), memory content that is available but not accessible, across two experiments. In both experiments, participants responded to 100 short-answer general knowledge questions, selecting a phenomenological category to represent their …
Gut Dysbiosis Correlates With Covid-19 Severity, Ednita Escobar
Gut Dysbiosis Correlates With Covid-19 Severity, Ednita Escobar
CMC Senior Theses
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) impacts not only respiratory but also gut and oral microbiomes, influencing the manifestations of COVID-19. Each person’s unique microbiome consists of microorganisms such as bacteria, fungi, and viruses, some of which are symbiotic and others potentially harmful. Alterations in the gut microbiome, specifically, can affect the severity and symptoms of COVID-19. A review of studies indicate a pattern of gut dysbiosis in COVID-19 patients characterized by a decrease in beneficial microbiota and/or an increase in opportunistic pathogens. This gut imbalance correlates with disease severity, suggesting that the gut microbiome plays a significant role …
The Standing Of Anger: Insights From The Debate(S) On Constructed Emotion, Andrew Holzer
The Standing Of Anger: Insights From The Debate(S) On Constructed Emotion, Andrew Holzer
CMC Senior Theses
In her book, Anger and Forgiveness: Resentment, Generosity, Justice, Martha Nussbaum argues that anger is inherently flawed because it fundamentally contains the desire for payback. To support her argument, she posits specific metaphysical claims about the nature of emotions like anger. This thesis is an extended critique of her metaphysical foundation from the perspective of empirical research in the neuroscience of emotion. The first reason to dispute this picture is descriptive; this view of anger is based on an outdated version of cognitive appraisal theory, which sees emotions as triggered directly by static moments of cognitive appraisal. The second …
Mental Imagery Contributes To Loss Aversion By Amplifying Negative Emotions, Daniel Kroshchuk
Mental Imagery Contributes To Loss Aversion By Amplifying Negative Emotions, Daniel Kroshchuk
CMC Senior Theses
Defined as the experience of sensory information without the presence of external stimuli, mental imagery is thought to play a role in memory, emotional regulation, and decision-making. Recent studies suggest that mental imagery varies widely across the general population, with approximately 2-4% of individuals having a reduction or complete absence of visual imagination, a phenomenon known as aphantasia. Individuals with aphantasia show reduced emotional arousal to fear-inducing imagery, raising the question of how variation in imagery affects cognitive processes that are influenced by emotion. Specifically, in economic decision-making it has been shown that the prospect of loss triggers negative emotions, …
Beauty Of Life In Dynamical Systems: Philosophical Musings And Resources For Students, Soumya Banerjee, Joyeeta Ghose, Tarakeswar Banerjee, Kalyani Banerjee
Beauty Of Life In Dynamical Systems: Philosophical Musings And Resources For Students, Soumya Banerjee, Joyeeta Ghose, Tarakeswar Banerjee, Kalyani Banerjee
Journal of Humanistic Mathematics
Information plays a key role in life and in complex biological systems, and dynamical systems underlie and can be used to represent many complex systems. Indeed, dynamical systems and information processing capabilities may be the hallmarks of life-like systems. In this paper we combine dynamical systems with a computational framework to generate art. The framework can be used to generate aesthetically appealing forms of life-like systems. Our work suggests that we may need an ``aesthetic sense'' to recognize life that we have not seen before. We also provide teaching resources for students in schools and undergraduate institutions.
Embracing Ai/Ml In Genetic Counseling: A Nationwide Survey On Program Leaderships’ Perspectives And Curriculum Integration, Kyla Holmes
KGI Theses and Dissertations
This study aimed to examine the attitudes and preparedness of genetic counseling program directors and faculty leadership in incorporating artificial intelligence and machine learning (AI/ML) into their curricula and its effect on core competency proficiency. AI/ML has been instrumental in creating and maintaining vital analytical tools and models employed by genetic counselors (GCs). However, research on the attitudes of faculty leadership in charge of training future GCs is limited. A nationwide survey conducted between November 2022 and February 2023 gathered 15 respondents holding diverse academic positions in genetic counseling program curriculum development. The majority of respondents had encountered AI/ML in …
The Development Of A Primer Payload With Microparticles For Uti Pathogen Identification Using Polythymidine- Modified Lamp Primers In Droplet Lamp, Jonas Otoo
KGI Theses and Dissertations
Nucleic acid amplification tests (NAATs) are among the diagnostic tests with the highest sensitivity and specificity. However, they are more complex to develop than other diagnostic tests such as biochemical tests and lateral flow immunoassay tests. Polymerase chain reaction (PCR) is the gold standard for NAATs. PCR requires thermal cycling to achieve clonal amplification of the target pathogen DNA for diagnosis. Thermal cycling poses a challenge in the development of PCR diagnostics for point-of-care (POC) settings. Loop-mediated isothermal amplification (LAMP) offers an isothermal method for NAATs diagnostics. The advancement of the microfluidics field significantly enhances the development of LAMP diagnostics …
Integrating Theatre And Biology: How Embodied Performance Can Enhance Empathy Among College Science Students, Annika C. Speer, Begona Echeverria
Integrating Theatre And Biology: How Embodied Performance Can Enhance Empathy Among College Science Students, Annika C. Speer, Begona Echeverria
The STEAM Journal
In these field notes, we examine the integration of the arts into a 20-person honors biology seminar at UC Riverside “Beyond Science: Being Humane Amid Human Rights Crises.” We held a four-hour workshop to examine the ways in which performance and theatrical storytelling can enhance science learning. The workshop provided a unique avenue for exploring how human activities result in downward consequences including refugee displacement, one of the course objectives. In addition to the workshop, we conducted surveys and a focus group with the students to better understand their experience incorporating the arts into their science class. A key concept …
Dear Duck-Billed Platypus, Michael J. Leach Dr
Dear Duck-Billed Platypus, Michael J. Leach Dr
The STEAM Journal
This piece is a concrete poem that both shows and describes the platypus (Ornithorhynchus anatinus).
Light Leaf: Observations Of Leaves In Light, Paul Kelley
Light Leaf: Observations Of Leaves In Light, Paul Kelley
The STEAM Journal
For me, spending time in isolation yielded some interesting findings, as I began to closely observe the various leaves that engulf my backyard. Every new day brought with it a new detail, a subtlety with every shift in light, revealing an endless array of abstractions, textures and colors. I was seeing the hidden life of leaves dancing in the sunlight. Naturally, I began documenting my observations.
Students Arts Participation Increases Stem Motivation Via Self-Efficacy, Stephen M. Dahlem
Students Arts Participation Increases Stem Motivation Via Self-Efficacy, Stephen M. Dahlem
The STEAM Journal
This work found that there exists a correlation between student motivation in science, technology, engineering and mathematics (STEM) and student participation in the arts during high school with self-efficacy being a mediator. STEM is an important component of student success from a broad, national, perspective, as well as from a domain-specific point of view. The results of this work may provide aid to teachers, parents, administrators, and even students seeking to find ways to increase student motivation and performance in the STEM subjects. Additionally, this work may be of interest to advocates of the arts. This quantitative correlational study was …
Challenge-Based Learning & Steam Curriculum, Diana Lockwood
Challenge-Based Learning & Steam Curriculum, Diana Lockwood
The STEAM Journal
STEAM education is being integrated into elementary schools as a way to engage more students in creativity, hands-on learning, and problem-based learning also referred to as Challenge-Based-Learning (CBL). This article focuses on elementary educators’ curriculum design for STEAM and presenting students with open-ended questions phrased as a challenge as a way to raise student interest and achievement (DeJarnette, 2018; Hunter-Doniger, 2018). When students received challenges to solve, they felt more open to sharing their ideas since there was more than one potential right answer (DeJarnette, 2018; Drake, 2012). When implementing CBL, teachers act as facilitators using a constructivist approach as …
Contents 41(1–2)
Aliso: A Journal of Systematic and Floristic Botany
No abstract provided.
Comparative Leaf Water Absorption Between Chaparral Island And Mainland Taxa: A Common Garden Experiment, Humera S. Mirza, Lauren M. Tucker, Rodrigo Méndez-Alonzo, Edward G. Bobich, Frank W. Ewers
Comparative Leaf Water Absorption Between Chaparral Island And Mainland Taxa: A Common Garden Experiment, Humera S. Mirza, Lauren M. Tucker, Rodrigo Méndez-Alonzo, Edward G. Bobich, Frank W. Ewers
Aliso: A Journal of Systematic and Floristic Botany
In California and other Mediterranean-type ecosystems, island species are typically exposed to more fog but less rain than mainland species. Because adaptations to absorb water from fog may conflict with those to minimize water loss, we hypothesized that island species should have greater fog absorption than their mainland congeners due to foliar uptake but at the cost of modifying other leaf structural and functional traits. To determine whether foliar water absorption is an adaptation to insularity, we compared seven physiological and anatomical leaf traits between congeneric island and mainland species of two genera, Ceanothus and Arctostaphylos, in a common …
A Tribute To Gary D. Wallace
Aliso: A Journal of Systematic and Floristic Botany
No abstract provided.
A Vascular Flora Of The South Fork Tule River, Southern Sierra Nevada, Tulare County, California, Jessica M. Orozco
A Vascular Flora Of The South Fork Tule River, Southern Sierra Nevada, Tulare County, California, Jessica M. Orozco
Aliso: A Journal of Systematic and Floristic Botany
I conducted a floristic study of the South Fork Tule River watershed, located in the southern Sierra Nevada in Tulare County, California. The primary objectives of this floristic study were to document and catalogue all vascular plant taxa that occur in the watershed, describe the plant communities, analyze the flora and its affinities with other areas, and establish a herbarium for the Tule River Indian Reservation. The upper reaches of the South Fork Tule River originate on the western slope of Slate Mountain in the Sequoia National Forest and drain west through the Tule River Indian Reservation into Lake Success. …
Forty Years Of Change In Piute Cypress (Hesperocyparis Nevadensis), A Rare California Tree, After Frequent Fire And Drought, Amarina Wuenschel, Jim A. Bartel, Alexis Bernal
Forty Years Of Change In Piute Cypress (Hesperocyparis Nevadensis), A Rare California Tree, After Frequent Fire And Drought, Amarina Wuenschel, Jim A. Bartel, Alexis Bernal
Aliso: A Journal of Systematic and Floristic Botany
Piute cypress (Hesperocyparis nevadensis) is a rare cypress species endemic to the Lake Isabella region in the southern Sierra Nevada in California. Piute cypress groves have not been quantitatively studied in the last 40 years and with recent fires (some in short succession) and observed mortality, we had questions surrounding conditions in groves recovering from fire compared to other groves with no recorded fire histories. Piute cypress rarely survive fire and are obligate seeders with serotinous cones and, as such, require sufficient time after fire to grow to reproductive maturity to be able to withstand future fire. We …
Using Computational Fluid Dynamics And Optical Sensor Technology To Scale Cell Culture Platforms, Mandar Makwana
Using Computational Fluid Dynamics And Optical Sensor Technology To Scale Cell Culture Platforms, Mandar Makwana
KGI Theses and Dissertations
Different cell culture vessels ranging from micro scale to laboratory scale to commercial scale play critical role in upstream process development for biologics manufacturing. Based on the mode of operation, cell culture vessels have different hydrodynamic environments, making it challenging to scale. Integrated approaches using computational tools supported by experimental studies can overcome these challenges. Computational Fluid Dynamics (CFD) is one such tool that can simulate hydrodynamics within the cell culture vessels and can provide insights at macro and micro-scale. Accuracy of a CFD model significantly depends on the fluid model and assumptions. Traditionally, simple two-equation fluid models were developed …
Biogeography Of Special Metabolites Produced By Ant-Associated Bacteria, Katherine Hansen
Biogeography Of Special Metabolites Produced By Ant-Associated Bacteria, Katherine Hansen
Scripps Senior Theses
There is an urgent and growing need for novel antibiotics with the growing prevalence of antibiotic-resistant pathogens. Ecologically-guided discovery is a strategy that focuses on how and where specially evolved metabolites such as antibiotics are used in nature. This strategy reveals unique active molecules with potential for human use. An unexplored niche with great potential for antibiotic discovery exists with Southwestern fungus-farming Trachymyrmex ants and their Actinobacteria symbionts. In exchange for nutrients from the ant, the ants’ bacterial symbiont produces antifungal molecules that protect the ants’ fungal cultivar from invasion by pathogenic microorganisms. They also produce antibacterial molecules to protect …
Nitrogen Isotopes In Deep Sea Corals; A Potential Tracer Of Paleoceanographic Conditions, Sylvia Bergerud
Nitrogen Isotopes In Deep Sea Corals; A Potential Tracer Of Paleoceanographic Conditions, Sylvia Bergerud
Scripps Senior Theses
Abstract
In the face of anthropogenic climate change, increasing pressure is being mounted on contextualizing current climate altercations compared to those of the past. One key tracer of climate variation is the isotopic ratio of 15N compared to 14N, which tracks biological and chemical reactions throughout the N cycle. However, it is difficult to find accurate palaeoceanographic records of N isotope fractionation, as most sedimentary and organic samples are subject to extensive diagenesis, degradation, and erosive processes. Scleractinian corals present a potential solution to this lack of accurate data. Multiple studies indicate that, due to their protective aragonite skeletons and …
An Analysis Of Water Quality At Orange County, California Beaches, Naomi Meurice
An Analysis Of Water Quality At Orange County, California Beaches, Naomi Meurice
Pomona Senior Theses
Beaches in Southern California are highly recreated by residents and visitors, making beaches socially and economically important. Public health departments in coastal communities are in charge of measuring water quality and ensuring it is safe for users. Research in the past has indicated that beach water quality gets worse after storms, with bacteria levels jumping on the day of a storm and staying high for up to five days. Studies have shown these spikes in bacteria to be associated with storm runoff, with beaches closer to runoff discharge locations experiencing more impact. However, prior research has not considered the period …
Copy Number Alterations Of Aggressive Pituitary Neuroendocrine Tumors, Grace Zhang
Copy Number Alterations Of Aggressive Pituitary Neuroendocrine Tumors, Grace Zhang
Scripps Senior Theses
Pituitary neuroendocrine tumors (PitNETs) are tumors of the pituitary gland. Although most are benign, they can cause severe morbidity if compression of surrounding tissue and/or endocrinopathies occur.
Aggressive PitNETs are notably detrimental and difficult to predict, and their effects are further exacerbated by challenges in treatment. Although histological studies can detect certain markers of tumor aggressiveness, they are insufficient at wholly predicting PitNET aggressiveness, making the clinical behavior of PitNETs challenging to determine. Since treatment of aggressive tumors also remains suboptimal, this further results in negative impacts on health and quality of life.
Genetic markers, such as copy number variations …
Variation In Soil-Mediated Drought Response Traits Between Sympatric Species Of Mimulus, Anna Reitman
Variation In Soil-Mediated Drought Response Traits Between Sympatric Species Of Mimulus, Anna Reitman
Scripps Senior Theses
The ‘time limitation hypothesis’ is an evolutionary theory regarding evolution in angiosperms. The theory attributes ephemeral drought stress to transitions from a perennial to annual life history and an animal- to self-pollinating mating style. The most influential edaphic parameter on water availability is soil texture (i.e. grain size) due to its controls on porosity. Adhesion weakens with coarseness allowing for expedited rates of water loss via evaporation and percolation. The potential implications of coarse soil textures on major transitions in angiosperms due to drought mediation as the ‘time-limitation hypothesis’ proposes has yet to be thoroughly examined. Here, we grew two …
Oral Contraceptives And Affective Disorders: Neurobiology And Informed Choice, Sophia Mae Drezner
Oral Contraceptives And Affective Disorders: Neurobiology And Informed Choice, Sophia Mae Drezner
Scripps Senior Theses
Pregnancy prevention and female reproductive freedom have been some of the most contested political issues for decades. Abortion, a fundamental part of women’s healthcare, divides liberals and conservatives on an international scale. The consequences of unintended pregnancy without safe and reliable contraception are widespread, disproportionately impacting women of color, trans and non-binary folks, and poorer communities. The birth control pill is the most common form of oral contraception (OC) globally. Many people with ovaries begin the pill or other hormonal contraceptive (HC) methods as young as 11 years old. Exogenous progesterone and estrogen are known to impact mood, affect, physiology, …
Cultivating Carrots, Community, And Health-Conscious Children: Investigating The Effects Of Community Garden Implementation On Nutrition Attitudes Of Elementary Students In The Los Angeles Unified School District, Hannah Michele Tiedemann
Cultivating Carrots, Community, And Health-Conscious Children: Investigating The Effects Of Community Garden Implementation On Nutrition Attitudes Of Elementary Students In The Los Angeles Unified School District, Hannah Michele Tiedemann
Scripps Senior Theses
Growing up in an urban food desert can significantly affect children's development, health, and well-being (Jencks et al., 1990; Leventhal et al., 2000). Compared to their more affluent peers, youth living in low-socioeconomic urban neighborhoods are at greater risk of experiencing poor-quality diets, food insecurity, unhealthy body weights, and mental health problems (Duncan et al., 1997; Sampson et al., 1997). Moreover, children living in food-insecure households are more likely to consume calorically dense diets high in trans fat and added sugar, putting them at risk for poor health, childhood obesity, and chronic, diet-related diseases as adults (Nielsen et al., 2002). …