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Searching For Binding Partners For The Novel Phkg1 Variant, Phkγ 181, Kishore Polireddy Apr 2008

Searching For Binding Partners For The Novel Phkg1 Variant, Phkγ 181, Kishore Polireddy

Student Research Conference Select Presentations

Phopshorylase kinase (PhK) is a hexadecameric holoenzyme made up of four different subunits in the arrangement (αβγδ)4 and has total molecular mass of 1.3MDa. Alpha and β are regulatory subunits, γ is catalytic, and δ is an intrinsic molecule of calmodulin. PhK is a serine threonine kinase with glycogenolytic regulatory functions. Our lab has recently discovered that the γ subunit can be alternatively processed to produce a truncated form of 181 residues (γ-181). This variant of γ contains a phosphorylation site for PK-C, and its activity is influenced by this phosphorylation. We are using a LexA based yeast two hybrid …


Recommended By Duncan Hines, Donna C. Parker, Jonathan J. Jeffrey Feb 2008

Recommended By Duncan Hines, Donna C. Parker, Jonathan J. Jeffrey

SCL Faculty and Staff Publications

Businessman, salesman, kitchen inspector, lover of comfortable lodgings, and connoisseur of good food - - this was the man Duncan Hines. This presentation explores the life and work of Duncan Hines from his days growing up in Warren County, Kentucky, through his career as a travel writer, and finally to his rise as a brand name in the world of packaged goods. The presentation highlights scenes from The Kentucky Library and Museum exhibit “Recommended by Duncan Hines.”