Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 1 of 1
Full-Text Articles in Life Sciences
In Vivo Effects Of Malathion On Glutathione-S-Transferase And Acetylcholinesterase Activities In Various Tissues Of Neonatal Rats, Suna Ti̇mur, Seçi̇l Önal, N.Ülkü Karabay, Ferah Sayim, Fi̇gen Zi̇hni̇oğlu
In Vivo Effects Of Malathion On Glutathione-S-Transferase And Acetylcholinesterase Activities In Various Tissues Of Neonatal Rats, Suna Ti̇mur, Seçi̇l Önal, N.Ülkü Karabay, Ferah Sayim, Fi̇gen Zi̇hni̇oğlu
Turkish Journal of Zoology
Glutathione-S-transferase (GST) has been reported to play an important role in the detoxification of several chemical compounds, including pesticides. Organophosphate pesticides are potent inhibitors of acetylcholinesterase (AChE). The present study was conducted to assess the in vivo effects of the organophosphate pesticide malathion on the activity of GST and AChE and the protein levels of different organs in neonatal rats. GST activity increased approximately two-fold in adult female rats fed malathion, whereas AChE activity decreased less than 20% of the control in the liver. Similarly, liver and heart GST activities (0.14 and 0.035 U/mg protein, respectively) were also increased approximately …