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Differential Classical Conditioning Of The Gill-Withdrawal Reflex In Aplysia Recruits Both Nmda Receptor-Dependent Enhancement And Nmda Receptor-Dependent Depression Of The Reflex, Shekib A. Jami, William G. Wright, David L. Glanzman
Differential Classical Conditioning Of The Gill-Withdrawal Reflex In Aplysia Recruits Both Nmda Receptor-Dependent Enhancement And Nmda Receptor-Dependent Depression Of The Reflex, Shekib A. Jami, William G. Wright, David L. Glanzman
Biology, Chemistry, and Environmental Sciences Faculty Articles and Research
Differential classical conditioning of the gill-withdrawal response (GWR) in Aplysia can be elicited by training in which a conditioned stimulus (CS) delivered to one side of the siphon (the CS+) is paired with a noxious unconditioned stimulus (US; tail shock), while a second conditioned stimulus (the CS-), delivered to a different siphon site, is unpaired with the US. NMDA receptor(NMDAR) activation has been shown previously to be critical for nondifferential classical conditioning in Aplysia. Here, we used a semi-intact preparation to test whether differential classical conditioning of the GWR also depends on activation of NMDARs. Differential training produced conditioned enhancement …