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Study Of An Analytical Method For Benzo(A)Pyrene Metabolites In Human Urine, Zheng Ouyang
Study Of An Analytical Method For Benzo(A)Pyrene Metabolites In Human Urine, Zheng Ouyang
Theses
A method developed by Becher and Bjorseth for analysis of PAH metabolites in urine was employed to investigate human exposure to benzo(a)pyrene (BaP) - an ubiquitous environmental carcinogen. Preliminary results are presented showing the relationship between exposure to BaP and urinary elimination. Although the correlation between the two variables is not statistically significant, there appears to be a positive association with selected exposure varibles such as smoking. The identification of an association may establish urinary BaP as a marker of exposure.
However, detailed study of the analytical procedure indicated that recoveries with this method were as low as 3-8% for …