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Structure And Function Of Stomatin-Like Protein 2, Safee Mian
Structure And Function Of Stomatin-Like Protein 2, Safee Mian
Electronic Thesis and Dissertation Repository
Stomatin-like protein 2 (SLP-2), a member of the SPFH superfamily, is a mitochondrial inner membrane protein required for optimal mitochondrial respiration. SLP-2 binds to the important mitochondrial phospholipid cardiolipin (CL) and has been proposed to mediate formation of CL-enriched microdomains that would foster respiratory chain supercomplex (RCS) formation and stability. However, little is known about how SLP-2 structure facilitates its cellular function. The goal of this thesis was to elucidate if and how SLP-2 oligomerizes and by what means does it bind CL.
Biophysical analysis of the expressed SLP-2 SPFH domain, either with or without flanking residues, indicates it to …