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Full-Text Articles in Life Sciences
Phleborheography: A Correlative Study With Venography, Joseph P. Elliott Jr., John H. Hageman, Ann C. Belanger, Roger F. Smith
Phleborheography: A Correlative Study With Venography, Joseph P. Elliott Jr., John H. Hageman, Ann C. Belanger, Roger F. Smith
Henry Ford Hospital Medical Journal
The Vascular Laboratory of Henry Ford Hospital has used the Cranley-Grass Phleborheograph (PRG) as the primary noninvasive method to determine the presence or absence of deep venous thrombosis (DVT) in the lower limbs since December 1977. In order to determine its proper role and clinical reliability, we compared the diagnostic accuracy of phleborheography with contrast venography. From December 1977 through December 1978, 483 cases (963 limbs) were successfully examined by PRG. Ofthese, 111 cases (216 limbs) also had contrast venography. The PRG was confirmed as normal in 151 out of 157 (6 false negatives). There were 53 abnormal PRCs, with …
Glucose Phosphate Isomerase Deficiency: Unusual Acute Hemolytic Crisis In A Middle-Aged Woman, Koichi Maeda, Sheikh M. Saeed, Raymond W. Monto, Ernest Beutler
Glucose Phosphate Isomerase Deficiency: Unusual Acute Hemolytic Crisis In A Middle-Aged Woman, Koichi Maeda, Sheikh M. Saeed, Raymond W. Monto, Ernest Beutler
Henry Ford Hospital Medical Journal
Hereditary hemolytic anemia associated with glucose phosphate isomerase (GPI) deficiency was first reported in 1967. Since then, about 30 cases have been reported in the literature; their ages ranged between 1 and 26 years. We present a case of glucose phosphate isomerase deficiency in a 56-year-old woman. Steroid therapy seemed to resolve our patient's acute stage. Since it has not been mentioned previously, further evaluation is necessary. Consideration of this deficiency may be helpful in investigating hemolytic anemia, regardless of the patient's age.
Intensity Of The Second Heart Sound: Relation Of Physical, Physiological And Anatomic Factors To Auscultatory Evaluation, Paul D. Stein, Hani Sabbah
Intensity Of The Second Heart Sound: Relation Of Physical, Physiological And Anatomic Factors To Auscultatory Evaluation, Paul D. Stein, Hani Sabbah
Henry Ford Hospital Medical Journal
The intensity of the heart sound depends upon: 1) the distensibility of the aortic and pulmonary valves; 2) hemodynamic factors that cause the valves to distend and vibrate; 3) viscosity of the blood and its ability to inhibit diastolic valve motion; 4) the configuration of the aorta, pulmonary artery, and ventricle and the ability of the walls of the great vessels and ventricles to absorb or reflect sound energy; and 5) the capability of sound to be transmitted to the chest wall. Recognizing how these physical, physiological, and anatomic factors interact can help us to interpret auscultation of the intensity …
A Selective Approach To Bleeding Esophageal Varices, Glyn G. Jamieson, Irwin B. Faris, John Ludbrook
A Selective Approach To Bleeding Esophageal Varices, Glyn G. Jamieson, Irwin B. Faris, John Ludbrook
Henry Ford Hospital Medical Journal
It is possible that the best results of treatment for bleeding esophageal varices will come when a selective approach is used. In patients bleeding acutely and in patients with poor liver function shunt operations should be avoided, and a direct attack on the varices with either sclerosant therapy, percutaneous obliteration, or staple gun gastro-esophageal transsection should be carried out. In patients who have stopped bleeding, or those in whom elective treatment is being undertaken, the best operation at present appears to be selective distal splenorenal shunt.
Henry Ford Hospital Clinicopathological Conference: Hypercoagulable State In Cancer Of The Pancreas In A 57-Year-Old Man
Henry Ford Hospital Medical Journal
No abstract provided.
Transiliac Bone Biopsy: Complications And Diagnostic Value, Sudhaker D. Rao, Velimir Matkovic, Howard Duncan
Transiliac Bone Biopsy: Complications And Diagnostic Value, Sudhaker D. Rao, Velimir Matkovic, Howard Duncan
Henry Ford Hospital Medical Journal
This article reviews the experience of 101 transiliac bone biopsies performed in one year at Henry Ford Hospital and discusses the possible diagnostic value ofthe procedure in evaluating generalized metabolic bone disease. In 50 of the 101 cases, we used a pain scoring method to evaluate the acceptability of the procedure to patients. Data from our study and 18 other clinical centers were then analyzed for: 1) demographic distribution of patients who had a bone biopsy; 2) its acceptability to patients; 3) quality of the specimen and its relationship to the physician performing the procedure; 4) diagnostic yield of bone …
Research In The Service-Oriented Institution, Richmond W. Smith Jr.
Research In The Service-Oriented Institution, Richmond W. Smith Jr.
Henry Ford Hospital Medical Journal
No abstract provided.
Osteoporosis And Epidemiology Of Fractures In Croatia: An International Comparison, Velimir Matkovic, Marija Ciganovic, Cedomil Tominac, Krista Kostial
Osteoporosis And Epidemiology Of Fractures In Croatia: An International Comparison, Velimir Matkovic, Marija Ciganovic, Cedomil Tominac, Krista Kostial
Henry Ford Hospital Medical Journal
We examined the epidemiology of osteoporotic fractures in Croatia and correlated the results with data from other countries. We analyzed annual rates of wrist fractures in the large urban community of Zagreb and hip fractures in the Republic of Croatia. In addition, we determined mortality data and measured metacarpal bone mass In patients with hip fractures. There were age and sex differences in the incidence of both types of fracture. The incidence of wrist fractures is the same as in some Northwestern European countries, but the incidence of hip fractures is much lower. The mortality after hip fractures is high …
Occult Cushing's Syndrome Presenting With Osteoporosis, M. Kleerekoper, Sudhaker D. Rao, B. Frame, R. D. Larocque, T. Feigelman, V. Matkovic, L. V. Avioli
Occult Cushing's Syndrome Presenting With Osteoporosis, M. Kleerekoper, Sudhaker D. Rao, B. Frame, R. D. Larocque, T. Feigelman, V. Matkovic, L. V. Avioli
Henry Ford Hospital Medical Journal
Osteoporosis is a frequent complication both of endogenous hypercortisolism and of long-term treatment with corticosteroids, but only rarely is it the major clinical feature with the more characteristic features absent or minimally present. In the two patients presented, hypercortisolism was uncovered only during routine evaluation of osteoporosis. This presentation is probably due to slow progression of the disease and is often associated with so-called black adenoma of the adrenal gland. Secondary causes should be sought in all patients with seemingly "senile" or "postmenopausal" osteoporosis.
Cushing's Disease, A Pituitary Disorder: A Hypothesis, M. Saeed Zafar, Raymond C. Mellinger
Cushing's Disease, A Pituitary Disorder: A Hypothesis, M. Saeed Zafar, Raymond C. Mellinger
Henry Ford Hospital Medical Journal
At present, Cushing's disease Is believed to be due to Inappropriate secretion of adrenocorticotropic hormone (ACTH). Associated abnormalities such as disturbed sleep pattern, growth hormone secretion, depressed thyroid hormone levels, and gonadal function are considered by some as manifestations of a generalized central nervous system disturbance, with abnormal ACTH secretion as one of the components. Recognition of microadenomata in Increasing numbers of patients with Cushing's disease, the reversal of hypothalamic abnormalities after adenomectomy, and correction of hypercortisolemia all suggest that the central nervous system disturbances result from Cortisol excess. We hypothesize that the basic abnormality in Cushing's disease is the …
Recurrent Klebsiella Meningitis Following Trans-Sphenoidal Hypophysectomy For Nelson's Syndrome: Chloramphenicol Resistance During Relapse, Tom Madhavan, Daria Kiani, Louis Saravolatz, Keith Burch, Raymond C. Mellinger
Recurrent Klebsiella Meningitis Following Trans-Sphenoidal Hypophysectomy For Nelson's Syndrome: Chloramphenicol Resistance During Relapse, Tom Madhavan, Daria Kiani, Louis Saravolatz, Keith Burch, Raymond C. Mellinger
Henry Ford Hospital Medical Journal
Three episodes of meningitis due to Klebsiella pneumoniae occurred in a young man following cerebral surgery. The patient had the features of Nelson's syndrome, and a chromophobe adenoma was removed by trans-sphenoidal resection. Intravenous chloramphenicol was effective in producing a temporary clinical response during the first episode of meningitis, but the organism became resistant to chloramphenicol during the second episode. Combined parenteral and intralumbar administration of gentamicin resulted in temporary improvement only. Subsequently, the subcutaneous cerebrospinal fluid (CSF) reservoir of Ommaya provided a safe, convenient way to administer prolonged intraventricular therapy which, combined with a definitive procedure to correct the …
The Impact Of Needle Biopsy On The Preoperative Diagnosis Of Thyroid Nodules, J. Martin Miller, Joel I. Hamburger, Sudha R. Kini
The Impact Of Needle Biopsy On The Preoperative Diagnosis Of Thyroid Nodules, J. Martin Miller, Joel I. Hamburger, Sudha R. Kini
Henry Ford Hospital Medical Journal
This study compares the noninvasive evaluation of 1,075 patients with "cold" thyroid nodules with the evaluation provided by needle biopsy. It also compares the treatment of this group with that of a similar group of 1,094 patients treated before biopsies were available. The results of these comparisons indicate that needle biopsy: 1) halved the number of surgical candidates; 2) doubled the percentage of cancers in the surgical specimens; 3) reduced the risk that a thyroid cancer would not be operated upon; and 4) accomplished all of the above with a substantial financial saving in overall patient management.
The Presentation Of Thyroid Malignancy In The Geriatric Patient, Joel I. Hamburger
The Presentation Of Thyroid Malignancy In The Geriatric Patient, Joel I. Hamburger
Henry Ford Hospital Medical Journal
Of 334 patients with thyroid carcinoma, 36 were age 65 or older. The sex distribution of the geriatric patients did not significantly differ from that of the younger patients. Older patients had significantly fewer papillary carcinomas and significantly more anaplastic and medullary carcinomas and lymphomas than younger patients. Papillary and follicular carcinomas of geriatric patients were large (4 cm or larger) significantly more often than those of the younger patients. Only one of 53 patients with very small (1 cm or less) papillary and follicular carcinomas was in the older group.
Graves' Disease Following The Occurrence Of Hypothyroidism, A. R. Guansing, D. D. Klink, N. Engbring, Y. Leung, J. Chakravarty, S. Wilson
Graves' Disease Following The Occurrence Of Hypothyroidism, A. R. Guansing, D. D. Klink, N. Engbring, Y. Leung, J. Chakravarty, S. Wilson
Henry Ford Hospital Medical Journal
Three patients with hypothyroidism of 15-48 months' duration developed Graves' disease while on thyroid hormone replacement therapy. In one patient, the hyperthyrold phase was preceded by ophthalmopathy and nonsuppresslble 24-hour radioactive iodine uptake (RAIU). Eventually, all had hyperthyrold findings with elevated thyroid hormone levels, high 24-hour RAIU, and a diffuse uniform uptake of RAI by the enlarged thyroid. All subjects had negative antithyroglobulin and antimicrosomal antibody titers. Two had demonstrable long-acting thyroid stimulator (LATS) in their sera. All three were followed for 5-36 months while on propylthiouracil therapy prior to surgery or RAI administration. Both LATS-positive patients underwent bilateral subtotal …
Insulin-Resistant Diabetes Mellitus And Insulin Receptor Antibodies: Variable Association With Acanthosis Nigricans, José Goldman
Insulin-Resistant Diabetes Mellitus And Insulin Receptor Antibodies: Variable Association With Acanthosis Nigricans, José Goldman
Henry Ford Hospital Medical Journal
Two patients with severe insulin-resistant diabetes mellitus and anti-insulin receptor autoantibodies are reported here. A marked decrease in the number of accessible insulin receptors was found in the monocytes of one patient. Otherwise, the Insulin receptors were of normal affinity compared to those of normal controls. Acanthosis nigricans was not present in one patient, and in the other patient it preceded the diagnosis of diabetes by ten years. We conclude that although acanthosis nigricans and insulin resistance are frequently associated, they probably do not bear a pathogenetic relationship to each other. Therefore, the investigation of anti-insulin receptor antibodies Is advisable …
Richmond Smith As A Clinical Investigator: His Work On Adult Periosteal Bone Expansion And Nutritional And Endocrine Aspects Of Osteoporosis In Light Of Current Concepts, A. M. Parfitt
Henry Ford Hospital Medical Journal
This paper discusses Richmond Smith's contributions to the field of metabolic bone disease from 1949 to 1969 in light of current concepts. He was the first to demonstrate continuing periosteal bone expansion in adults, a phenomenon of great biologic interest which is best explained if adult bone remodelling is qualitatively similar on all surfaces. He was the first to show that persons with less bone than normal have an increased risk of subsequent fracture, and so are more likely to benefit from preventive treatment. He found that blood vitamin D levels were lower in osteoporotic subjects than in controls, but …
Prospects For Clinical Research, G. Donald Whedon
Prospects For Clinical Research, G. Donald Whedon
Henry Ford Hospital Medical Journal
No abstract provided.
The Acute Effect Of Piretanide Upon Serum And Urinary Calcium In Normal Subjects, Cristina Casco, Patricia Fainstein Day, Carlos Mautalen
The Acute Effect Of Piretanide Upon Serum And Urinary Calcium In Normal Subjects, Cristina Casco, Patricia Fainstein Day, Carlos Mautalen
Henry Ford Hospital Medical Journal
We gave piretanide, a new diuretic, at two dose levels to six normal subjects. Sodium excretion increased six to eightfold in the first two hours, and diuresis was completed within four hours. There was a simultaneous increase in the excretion of calcium which exceeded the amount present In the mobilized extracellular fluid. The resulting deficit of calcium produced a small but significant fall in serum calcium corrected for protein. After diuresis ended, calcium was retained but not sodium, when compared to basal values on the previous day. The fall in urinary calcium and the failure to correct the sodium deficit …
Richmond W. Smith Jr., Raymond C. Mellinger
Richmond W. Smith Jr., Raymond C. Mellinger
Henry Ford Hospital Medical Journal
No abstract provided.
Painless Thyroiditis With Hyperthyroidism Following External Irradiation To The Neck, J. David Fachnie, Sudhaker D. Rao
Painless Thyroiditis With Hyperthyroidism Following External Irradiation To The Neck, J. David Fachnie, Sudhaker D. Rao
Henry Ford Hospital Medical Journal
Two months after finishing 60Co external irradiation to treat squamous cell carcinoma of the larynx, a 47-year-old man became hyperthyrold. Although the thyroid gland was not tender, the radioactive iodine uptake was diminished. After subsequent periods of euthyroidism and hypothyroidism, the patient's thyroid function spontaneously returned to normal. The features of this case mimic the syndrome of painless granulomatous thyroiditis. Although hypothyroidism is frequently observed following radiation thyroiditis, hyperthyroidism from external radiation has not been reported. Despite this low frequency, diagnosis is important to permit prompt, symptomatic treatment of the thyrotoxic phase.
Dietary And Hormonal Factors In Bone Loss, Richmond W. Smith Jr.
Dietary And Hormonal Factors In Bone Loss, Richmond W. Smith Jr.
Henry Ford Hospital Medical Journal
No abstract provided.
Femoral Expansion In Aging Women: Implications For Osteoporosis And Fractures, Richmond W. Smith Jr., Richard R. Walker
Femoral Expansion In Aging Women: Implications For Osteoporosis And Fractures, Richmond W. Smith Jr., Richard R. Walker
Henry Ford Hospital Medical Journal
In femoral radiographs of 2030 aging women, the diameter of the midshaft periosteum increased as cortical thickness declined. Since the cortical area enlarged, periosteal accretion exceeded endosteal resorption. Since the section modulus increased more than did cortical area, the ratio of flexural failure resistance to crush resistance increased, in apparent contrast to the changes observed in the femoral neck.
The Recognition Of Active Retrolental Fibroplasia, R. Michael Nisbet
The Recognition Of Active Retrolental Fibroplasia, R. Michael Nisbet
Henry Ford Hospital Medical Journal
As the incidence of retrolental fibroplasia increases, physicians must become familiar with its appearance. This report describes the examination techniques and morphology of the active and regressive stages of retrolental fibroplasia.
1980 Beaumont Lecture: Restriction Enzymes As Tools For Genetic Research, Hamilton O. Smith
1980 Beaumont Lecture: Restriction Enzymes As Tools For Genetic Research, Hamilton O. Smith
Henry Ford Hospital Medical Journal
No abstract provided.
Danazol Therapy In Hereditary Angioedema, Lawrence C. Sweet, Charles E. Jackson, Sam S. Yanari, J. B. Yott
Danazol Therapy In Hereditary Angioedema, Lawrence C. Sweet, Charles E. Jackson, Sam S. Yanari, J. B. Yott
Henry Ford Hospital Medical Journal
Herditary angioedema (HAE) is an autosomal dominantly inherited condition in which a deficiency of the inhibitor (C1lnh) of the activated first component of complement is associated with recurrent episodes of edema of the skin, gastrointestinal tract, and larynx. The pituitary gonadotropin inhibitor, danazol, has been reported to be effective in preventing attacks and increasing C1lnh levels. Our experience with 11 patients from five kindreds corroborated those results and has revealed that most patients can be maintained symptom-free on 100-200 mg of danazol daily Side effects were minimal, although one young woman discontinued therapy because it aggravated her acne. The elevation …