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Function Of The Notch/Delta Pathway In Ophthalmic Trigeminal Placode Development, Matthew K. Ball
Function Of The Notch/Delta Pathway In Ophthalmic Trigeminal Placode Development, Matthew K. Ball
Theses and Dissertations
The ophthalmic trigeminal placode (opV) is the birth place of one cell type of sensory neurons contributing to the trigeminal ganglion. Signals from the neural tube induce placodal identity within the surface ectoderm. Specified opV placode cells then up-regulate neuron differentiation markers and migrate to the ganglion. Several molecular pathways have been shown to act in opV placode cell development. Despite this, signals that specify individual neurons from within the opV placode remain unknown. However, it is known that components of the Notch signaling pathway are expressed in the opV placode. I tested the role of Notch signaling in opV …