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Distinct Roles Of Gaba(A)R Signaling In The Regulation Of Two Human T Lymphocyte Lines, Ying Lin
Distinct Roles Of Gaba(A)R Signaling In The Regulation Of Two Human T Lymphocyte Lines, Ying Lin
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In response to antigen presentation, helper T lymphocytes (TH cells) initiate store-operated Ca2+ entry (SOCE) and differentiate into effector subtypes such as TH1 and TH2 cells. These cells play essential roles in adaptive immunity and the pathogenesis of various autoimmune and allergic diseases. The differentiation and activity of TH cells are also critically regulated by paracrine and autocrine soluble factors in the cell microenvironment. Previous studies have reported that TH cells produce gamma-aminobutyric acid (GABA) via glutamic acid decarboxylase (GAD) and express A-type GABA receptors (GABAARs), forming an autocrine GABA …