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Exercise Mitigates The Effects Of Hyperhomocysteinemia On Adverse Skeletal Muscle Remodeling., Lee Winchester
Exercise Mitigates The Effects Of Hyperhomocysteinemia On Adverse Skeletal Muscle Remodeling., Lee Winchester
Electronic Theses and Dissertations
Background: Hyperhomocysteinemia (HHcy) is heavily implicated in diabetes and cardiovascular disease. HHcy is known for causing inflammation and vascular remodeling, particularly through production of reactive oxygen species (ROS) and matrix metalloproteinase-9 (MMP-9). Although its impact on skeletal muscle is rather unclear, HHcy is known to cause skeletal muscle weakness and functional impairment. The impact of HHcy on inflammation makes it seem likely that HHcy causes skeletal muscle fibrosis through induction of inflammatory factors and destructive macrophages. Exercise has been shown to reduce homocysteine levels and therefore, could serve as a promising intervention for HHcy. The purpose of this study was …