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How Are Agricultural Research Projects Conceiving Innovation? An Assessment Of The European Union Multi-Actor Projects, Samuel Brea Martinez-Collado Dec 2021

How Are Agricultural Research Projects Conceiving Innovation? An Assessment Of The European Union Multi-Actor Projects, Samuel Brea Martinez-Collado

Graduate Theses and Dissertations

Horizon research programs are the European Union’s lighthouse for innovation and research concerning the agri-food chain, the management of natural resources, and the bioeconomy. Their innovation strategy approach is one that pursues the practical application of the research via the collaboration of all actors involved. Such strategy is the reflection of a Multi-Actor Approach as their procedure to enhance innovation. This paper presents the main trends and directions 101 Multi-Actor Projects (MAPs) are following on said approach towards innovation. The analysis is based on the use of well-defined “pathways” and “measures” proposed in the Guidelines for Evaluation of Innovation in …


The Effects Of Commercial Harvest On The Density And Demography Of Aquatic Turtles In Arkansas, Andrhea Darleen Massey Dec 2021

The Effects Of Commercial Harvest On The Density And Demography Of Aquatic Turtles In Arkansas, Andrhea Darleen Massey

Graduate Theses and Dissertations

The United States is home to the second highest concentration of turtle species in the world, after Asia. As of 2018, there are 57 turtle species recognized within the US, 40% of which are listed as threatened or endangered, with the primary threats to population persistence identified as over-consumption and/or habitat loss. Within the US, the Mississippi Alluvial Valley (MAV) region represents the second highest turtle species richness, after the Mobile River Basin. The MAV region of Arkansas is one of the least regulated in terms of commercial aquatic turtle harvest and has undergone large-scale habitat conversion from bottomland hardwood …


Nutrient Uptake And Management Strategies In Recirculating Hydroponic Systems, Lauren Leigh Houston Dec 2021

Nutrient Uptake And Management Strategies In Recirculating Hydroponic Systems, Lauren Leigh Houston

Graduate Theses and Dissertations

Nutrient management in recirculating hydroponic systems requires the periodic replenishment of water and nutrients to the nutrient solution reservoir. Common nutrient management strategies, such as replenishing the reservoir with fresh solution and maintaining a constant solution electrical conductivity (EC), can lead to ion accumulation and nutrient imbalances since nutrients are taken up by roots and depleted from solution at different rates. To avoid nutritional disorders, commercial growers typically dump and replace the hydroponic solution periodically, which is wasteful and has an economic cost. A potential alternative is to specially formulate the nutrient replenishment solution to balance the supply of nutrients …


Economic Potash Fertilizer Rate Recommendations, Kimberly B. Oliver Dec 2021

Economic Potash Fertilizer Rate Recommendations, Kimberly B. Oliver

Graduate Theses and Dissertations

This thesis is comprised of two studies that estimate profit-maximizing potassium (K) fertilizer application rates for various crops across different time periods. Estimation of profit-maximizing fertilizer-K rate (K*) for both studies considered the initial soil test level of K (STK) and yield response information, as traditional recommendations do, and added crop price and the cost of fertilizer. Profit maximum occurs where the marginal revenue from additional yield is equal to the marginal cost of applying an additional unit of fertilizer-K. The first study calculated K* for corn (Zea mays) and cotton (Gossypium hirsutum) and compared results to previous studies on …


The Electrification Of The Kitchen: On The Energy Consumption Of Common Electric Cooking Appliances, Hozen Ricchie Rose Asok Rose Dec 2021

The Electrification Of The Kitchen: On The Energy Consumption Of Common Electric Cooking Appliances, Hozen Ricchie Rose Asok Rose

Graduate Theses and Dissertations

In developed countries, electricity has been gaining popularity as a source of energy for meal preparation. Utilizing electricity produced from renewable resources along with efficient electrical cooking appliances could result in sustainable clean cooking. The first objective of this research was to study the efficiency of common electrical cooking appliances—namely induction, resistance plate, resistance coil, infrared, and electric pot— by the water boiling test and the simmering test. The induction and electric pot were observed as the most efficient devices for the water boiling test. For simmering, which mimics many cooking processes, the electric pot and resistance coil were the …


Field Evaluation Of Struvite As A Phosphorus Source, Niyi Sunday Omidire Dec 2021

Field Evaluation Of Struvite As A Phosphorus Source, Niyi Sunday Omidire

Graduate Theses and Dissertations

Phosphorus (P) is an element that is crucial in many biological processes in all forms of life and is not substitutable. Excess P in wastewaters leading to the degradation of receiving waters or eutrophication once released is a major environmental concern. Removal of excess P from wastewater as the mineral struvite (MgNH4PO4·6H2O) could be a promising solution to reduce P discharge into receiving waters and can potentially provide a valuable fertilizer-P source for agricultural production. The objectives of this project were to evaluate the effects of: 1) chemically precipitated struvite (CPST), compared to triple superphosphate (TSP) and an unamended control …


Body Mass And Body Condition Variation Of Mallards (Anas Platyrhynchos) Within And Among Winters Within The Lower Mississippi Alluvial Valley, John Thompson Veon Dec 2021

Body Mass And Body Condition Variation Of Mallards (Anas Platyrhynchos) Within And Among Winters Within The Lower Mississippi Alluvial Valley, John Thompson Veon

Graduate Theses and Dissertations

Most North American waterfowl overwinter in southern North America before migrating back to breeding grounds in the northern US and Canada. These species face the challenge of needing to maintain or increase their body mass during an environmentally difficult winter period. Successful body mass maintenance during the winter period has major ramifications not only for their winter survival but for their fitness across the entire year. Recent research in Europe and the western United States suggests that the body mass of mallards (Anas platyrhynchos) has increased from the late 1960s to early 2000s. However, the factors responsible for increases in …


Effects Of Localized Oxygen Production By Electrolysis On The First-Generation Glucose Sensor Response, Nandita Halder Dec 2021

Effects Of Localized Oxygen Production By Electrolysis On The First-Generation Glucose Sensor Response, Nandita Halder

Graduate Theses and Dissertations

Glucose sensors are very important for detecting blood glucose both in vitro and in vivo. First-generation glucose biosensors were based on the glucose oxidase (GOx) enzyme using molecular oxygen as the electron acceptor and therefore oxygen dependent. Unfortunately for in-vivo work, oxygen in the body is variable and limited. Alternative approaches to overcome the oxygen dependency came with their own limitations. The widely used and commercially available ex-vivo glucose test strip uses a mediator in place of oxygen to free it from oxygen dependency. The mediator-based technology, in most cases cannot be transferred to in vivo applications due to the …


Use Patterns And Influencing Factors Of Irrigation Best Management Practices In The Lower Mississippi River Basin, Merri E. Day Dec 2021

Use Patterns And Influencing Factors Of Irrigation Best Management Practices In The Lower Mississippi River Basin, Merri E. Day

Graduate Theses and Dissertations

This study uses the 2016 Irrigation Survey from Arkansas, Louisiana, and Mississippi to document the use of irrigation best management practices (IBMPs), analyze use patterns, and use quantitative methods to determine factors that influence producers’ decisions regarding IBMPs. IBMPs included in the survey can be grouped as: field management practices (zero-grade leveling, precision-grade leveling, end blocking, warped surface, and deep tillage), water flow control practices (computerized pipe-hole selection, multiple-inlet irrigation, surge irrigation, alternate wetting and drying, cutback irrigation, flow meters, and pump timers), water recovery/storage practices (tail-water recovery system and on-farm storage reservoir), and advanced irrigation scheduling practices (soil moisture …


Data Analytics For Sustainable Food And Agriculture Systems, Megan Lord Reavis Dec 2021

Data Analytics For Sustainable Food And Agriculture Systems, Megan Lord Reavis

Graduate Theses and Dissertations

The increasing concentration of anthropogenic greenhouse gases in the atmosphere is altering the climate, posing a serious threat to global agriculture and food security. Agriculture and food production contribute a quarter of all GHG emissions produced, so there is a critical need to limit emissions in this area while increasing food production to feed the anticipated 10 billion people by 2050. To address the needs of the future, data-driven solutions are needed to guide decision-making and provide support for actionable climate mitigation and survival strategies. Research efforts must be focused on analyzing problems on multiple scales, identifying new ways to …


Palmer Amaranth [Amaranthus Palmeri (S.) Wats.] Resistance To S-Metolachlor In The Mid-Southern Us And S-Metolachlor Dissipation In Soil, Koffi Badou Jeremie Kouame Dec 2021

Palmer Amaranth [Amaranthus Palmeri (S.) Wats.] Resistance To S-Metolachlor In The Mid-Southern Us And S-Metolachlor Dissipation In Soil, Koffi Badou Jeremie Kouame

Graduate Theses and Dissertations

Palmer amaranth [Amaranthus palmeri (S.) Wats.] presents both a high genetic diversity and propensity to evolve resistance to herbicides of several sites-of-action which have made it one of the worst weeds in US agriculture. In Arkansas, Palmer amaranth is resistant to herbicides of seven sites-of-action, which are 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS) inhibitor, acetolactate synthase inhibitors, microtubule inhibitors, protoporphyrinogen oxidase inhibitors, very long chain fatty acid inhibitors, glutamine synthetase inhibitors, and hydroxyphenylpyruvate dioxygenase inhibitors. Sustainable management requires a better understanding of its biology and that of herbicide environmental fate. This research had five objectives: 1) characterize the current status of Palmer amaranth …


Engineering Fluorescently Labeled Human Fibroblast Growth Factor One Mutants And Characterizing Their Photophysics Properties Towards Designing Fret Assays, Mamello Mohale Dec 2021

Engineering Fluorescently Labeled Human Fibroblast Growth Factor One Mutants And Characterizing Their Photophysics Properties Towards Designing Fret Assays, Mamello Mohale

Graduate Theses and Dissertations

Human fibroblast growth factor one (hFGF1) belongs to a family of 22 FGF members produced by fibroblast cells. Cell signaling during physiological processes of angiogenesis and wound healing occurs when hFGF1 binds to its receptor (FGFR). However, when heterogenous homeostasis is not maintained, fibroblast cells exhibit excessive proliferation which can lead to a myriad of cancers. smFRET is an ultrasensitive distant dependent (1-10 nm) technique capable of resolving such heterogeneity in structural dynamics and binding affinities (Kd). Therefore, we successfully designed and characterized fluorescently labeled hFGF1 tracers which span the visible light region of the electromagnetic spectrum for use in …


Contrastive Learning For Unsupervised Auditory Texture Models, Christina Trexler Dec 2021

Contrastive Learning For Unsupervised Auditory Texture Models, Christina Trexler

Computer Science and Computer Engineering Undergraduate Honors Theses

Sounds with a high level of stationarity, also known as sound textures, have perceptually relevant features which can be captured by stimulus-computable models. This makes texture-like sounds, such as those made by rain, wind, and fire, an appealing test case for understanding the underlying mechanisms of auditory recognition. Previous auditory texture models typically measured statistics from auditory filter bank representations, and the statistics they used were somewhat ad-hoc, hand-engineered through a process of trial and error. Here, we investigate whether a better auditory texture representation can be obtained via contrastive learning, taking advantage of the stationarity of auditory textures to …


Cover Crop Effects On Near-Surface Soil Aggregate Stability In The Southern Mississippi Valley Loess (Mlra 134), Chandler M. Arel Dec 2021

Cover Crop Effects On Near-Surface Soil Aggregate Stability In The Southern Mississippi Valley Loess (Mlra 134), Chandler M. Arel

Crop, Soil and Environmental Sciences Undergraduate Honors Theses

Intensive agricultural cultivation within major land resource area (MLRA) 134, the Southern Mississippi Valley Loess, has led to soil erosion, soil compaction, and the overall destabilization of near-surface soil aggregates. The use of cover crops during the agricultural offseason has been shown to help alleviate soil compaction and provide stabilizing effects against soil erosion, which are particularly important as the silty soils of MLRA 134 have a large erosion potential. This study evaluated the effects of cover crop and no-cover crop treatment on silt-loam soils within MLRA 134. Treatments were implemented during Fall 2018 and Fall 2019 and consisted of …


The Pandemic, Climate Change And Farm Subsidies, Allen H. Olson, Edward J. Peterson Sep 2021

The Pandemic, Climate Change And Farm Subsidies, Allen H. Olson, Edward J. Peterson

Journal of Food Law & Policy

Many people believe that once the COVID-19 pandemic has passed, life will return to the way it was. This belief is both unrealistic and dangerous. It is unrealistic because the virus will be around for years if not indefinitely. The timeframe for the worst of the pandemic will depend on our ability to administer effective vaccines worldwide and the public’s willingness to accept continued social distancing in the meantime. The damage done to public health, the economy and individuals is already substantial and will get worse. Recovery will be slow and incomplete. The belief that life will return to the …


Consumer Perceptions Of Plastic-Free Food Packaging, Cara Conner Jul 2021

Consumer Perceptions Of Plastic-Free Food Packaging, Cara Conner

Human Nutrition and Hospitality Management Undergraduate Honors Theses

This study surveyed consumers in Fayetteville, Arkansas to assess their perceptions of plastic-free food packaging. Due to the COVID-19 pandemic, surveys were administered via email to Dale Bumpers College of Agricultural, Food and Life Sciences undergraduate students and faculty at the University of Arkansas. Eleven questions were asked in the survey. Numerical values were assigned to each answer option in order to interpret the results. The factors impacting consumer decisions to purchase foods packaged with or without plastic were ranked from greatest to least: sanitation/safety, availability where shopping, cost, shelf-life, and convenience. Food packaging materials were ranked from most to …


Assessing Impacts Of Winter-Hay Feeding On Soil And Forage Nutrient Dynamics In A Rotationally-Grazed Pasture System In Arkansas, Lawrence Gordon Berry Iv Jul 2021

Assessing Impacts Of Winter-Hay Feeding On Soil And Forage Nutrient Dynamics In A Rotationally-Grazed Pasture System In Arkansas, Lawrence Gordon Berry Iv

Graduate Theses and Dissertations

More than 38 % of United States’ rural land area was used for grazing (i.e., pastureland or rangeland) ruminant animals in 2017, constituting the largest private land use group. The expansive nature of these lands means that grazing and pasture management decisions have potential to impact water quality as well as profit margins. As a result, beef producers are under increased pressure from economic and environmental standpoints to limit application of nutrients beyond those required to grow the forage needed for animal consumption. At the same time, a large amount of nutrients is recycled back to pasture systems directly from …


Microfabrication And Electrochemical Characterization Of A Novel Su-8 Probe With An Array Of Individually Addressable Electrodes Suitable For Redox Cycling Experiments In Ultra-Small Volumes, Mahsa Lotfi Marchoubeh Jul 2021

Microfabrication And Electrochemical Characterization Of A Novel Su-8 Probe With An Array Of Individually Addressable Electrodes Suitable For Redox Cycling Experiments In Ultra-Small Volumes, Mahsa Lotfi Marchoubeh

Graduate Theses and Dissertations

Redox cycling is an electrochemical technique that utilizes closely spaced generator and collector electrodes to cycle reversible redox species between their oxidative states. With advantages in signal amplification, selectivity of species based on their electrochemical reaction mechanism, and limited or no background subtraction, this technique is well suited for selective detection of important electrochemically active molecules such as dopamine at basal or slowly changing levels.

Miniaturized medical devices have become an area of great interest for measurement of chemicals in limited volumes with low concentrations or in sensitive tissues. A probe on a polymeric SU-8 substrate with suitable dimensions and …


The Influence Of Peer Irrigators On The Extensive And Intensive Margin Of Irrigation Techniques, Victoria Bailey May 2021

The Influence Of Peer Irrigators On The Extensive And Intensive Margin Of Irrigation Techniques, Victoria Bailey

Graduate Theses and Dissertations

We examine how irrigation techniques in use by family and friends influence the use and share of land utilizing different irrigation techniques by Arkansas producers. A bivariate sample selection model simultaneously estimates how farm characteristics determine the use and explain the share of a farm that utilizes an irrigation technique. We find that the irrigation techniques in use by family and friends do affect the irrigation techniques a producer uses and the share of acres utilizing different irrigation techniques. A producer with a family or friend that uses end-blocking irrigation is 41% more likely to use end-blocking themselves. Having a …


Economic And Ecosystem Impacts Of Gm Maize In South Africa, Kristiina Ala-Kokko May 2021

Economic And Ecosystem Impacts Of Gm Maize In South Africa, Kristiina Ala-Kokko

Graduate Theses and Dissertations

White maize in South Africa is the only staple crop produced on a widespread commercial basis for direct human consumption using genetically modified (GM) cultivars. Using a combined economic and environmental approach, we estimate the total welfare benefits attributable to GM white maize in South Africa for 2001-2018 are $694.7 million. Food security benefits attributable to GM white maize in South Africa also manifest through an average of 4.6 million additional white maize rations annually. To achieve these additional annual rations using conventional hybrid maize, the additional land required would range from 1,088 hectares in 2001 to 217,788 hectares in …


Biochemical Characterization Of Small Molecule Inhibitor Binding On A Ras Related Gtpase And Its Effector Interactions, Djamali Muhoza May 2021

Biochemical Characterization Of Small Molecule Inhibitor Binding On A Ras Related Gtpase And Its Effector Interactions, Djamali Muhoza

Graduate Theses and Dissertations

The Ras superfamily of GTPases has 167 proteins that are involved in various cellular processes such as proliferation, transformation, migration, and inhibition of cell death. Mutations, abnormal expression, and function of these proteins are observed in many diseases, including several forms of cancer. Even though these GTPases were among the first discovered oncogenes, no successful Ras drug candidate has successfully passed clinical trials. Drugs targeting these proteins have failed mainly because of the complexity of their regulation, their high affinity to GTP, and their structure’s dynamic nature. Recently, novel promising targeting approaches have renewed interest in the Ras drug discovery …


Quantifying The Leaching Of Nutrients And Metals In A Pasture Soil As Affected By Excreta Of Ruminants Fed Alternative Diets, Ian Kennedy May 2021

Quantifying The Leaching Of Nutrients And Metals In A Pasture Soil As Affected By Excreta Of Ruminants Fed Alternative Diets, Ian Kennedy

Graduate Theses and Dissertations

The leaching of nitrate through the soil profile and into adjacent water systems has been a leading cause of water pollution and results in the loss of a valuable nutrient from animal production systems. Forage-based animal production systems may be improved through manipulation of animal diets that incorporate tannins and total polyphenolic compounds with feed, increasing the amount of nitrogen (N) retained by an animal/decreasing rates of digestion and altering the N-containing compounds that are excreted and deposited onto soil. Incorporating the forage legumes sericea lespedeza (Lespedeza cuneate [Dumont de Courset] G. Don) and lablab (Lablab purpurues L.) into the …


Long-Term Changes In Soil Surface Properties As Affected By Management Practices In A Wheat-Soybean, Double-Crop System, Machaela Morrison May 2021

Long-Term Changes In Soil Surface Properties As Affected By Management Practices In A Wheat-Soybean, Double-Crop System, Machaela Morrison

Crop, Soil and Environmental Sciences Undergraduate Honors Theses

Long-term agricultural sustainability and productivity are controlled by the integrative effects of different management practices on the soil. Many Arkansas producers use the double-crop system to grow soybeans [Glycine max (L.) Merr] and wheat (Triticum aestivum L.). Studying combinations of different, non-traditional, alternative agricultural techniques may help producers better understand the long-term implications of various management practice options on sustainability and productivity. The objective of this study was to evaluate the effects of agricultural management practices, including residue level, tillage, irrigation, and burning, and soil depth on the change in various soil properties from 2010 to 2020 in …


Estimating Irrigation In Rice Fields With A Water Balance Approach, Kristen Trinh May 2021

Estimating Irrigation In Rice Fields With A Water Balance Approach, Kristen Trinh

Biological and Agricultural Engineering Undergraduate Honors Theses

Global food production must increase to meet the demand associated with increased population growth, so irrigation water use will continue to rise. Therefore, it is important to monitor water usage particularly when an irrigation flowmeter is unavailable. A field water balance was created for a selection of rice fields in East-central Arkansas under observation in 2018 and 2019. From those, irrigation inputs are deduced from the water balance alone. First, each field had sensors that collected water table level (WTL) data. Next, other water inputs and outputs such as precipitation and evapotranspiration (ET) were collected from two modeled sources. The …


Comparative Analysis Of Azo Dye Restriction In The International Textile Industry, Kayla Demark May 2021

Comparative Analysis Of Azo Dye Restriction In The International Textile Industry, Kayla Demark

Apparel Merchandising and Product Development Undergraduate Honors Theses

Azo dyes are the most used type of dye in the textile industry. Some of these dyes have the potential to be extremely toxic to both human health and the environment. While regulations of these dyes vary across the world, it is suggested that not enough is being done to protect consumers and the environment from potentially harmful azo dyes (Rawat et al., 2016). It is the responsibility of apparel companies to ensure that their products that contain azo dyes are safe for consumers.

The purpose of this study was to understand how azo dyes and their by-products are restricted …


Climate-Driven Impacts On Himalayan Aquatic Biodiversity: A Case Study Involving Snowtrout (Cyprinidae: Schizothorax), Riri Wiyanti Retnaningtyas May 2021

Climate-Driven Impacts On Himalayan Aquatic Biodiversity: A Case Study Involving Snowtrout (Cyprinidae: Schizothorax), Riri Wiyanti Retnaningtyas

Graduate Theses and Dissertations

Monitoring biodiversity, to include its relative dispersal and contraction, has become a conservation task of great importance, particularly given the catastrophic and ongoing loss of habitat due to climate change. However, the timing, direction, and magnitude of these rates vary across taxa and ecosystems. Predicting specific impacts of climate change can thus be difficult and this, in turn, hampers management action. Metrics are needed to not only quantify contemporary requirements of species, but also predict potential distributions that fluctuate in lockstep with climate.

Montane ecosystems in the Himalayas are highly impacted by climate change, yet remain largely understudied due to …


Examining The Invasion Of A Bush Honeysuckle Using Climate Analysis, Andrew Palmer May 2021

Examining The Invasion Of A Bush Honeysuckle Using Climate Analysis, Andrew Palmer

Biological Sciences Undergraduate Honors Theses

Within the study of invasive plants, particular importance is placed on elucidating the mechanisms by which these plants proliferate and dominate within their introduced ranges. Several theories have been advanced to explain these invasions, each with different implications for the predicted range of invasive plants. Recent studies have provided support for the application of several invasion theories to Lonicera maackii, or what is more commonly referred to as bush honeysuckle. This species provides a unique opportunity to examine the efficacy of these theories in explaining the range expansion of invasive plants. L. maackii is endemic to eastern Asia, but …


Using Deep Learning For Children Brain Image Analysis, Rafael Toche Pizano May 2021

Using Deep Learning For Children Brain Image Analysis, Rafael Toche Pizano

Computer Science and Computer Engineering Undergraduate Honors Theses

Analyzing the correlation between brain volumetric/morphometry features and cognition/behavior in children is important in the field of pediatrics as identifying such relationships can help identify children who may be at risk for illnesses. Understanding these relationships can not only help identify children who may be at risk of illnesses, but it can also help evaluate strategies that promote brain development in children. Currently, one way to do this is to use traditional statistical methods such as a correlation analysis, but such an approach does not make it easy to generalize and predict how brain volumetric/morphometry will impact cognition/behavior. One of …


Trunctrimmer: A First Step Towards Automating Standard Bioinformatic Analysis, Z. Gunner Lawless, Dana Dittoe, Dale R. Thompson, Steven C. Ricke May 2021

Trunctrimmer: A First Step Towards Automating Standard Bioinformatic Analysis, Z. Gunner Lawless, Dana Dittoe, Dale R. Thompson, Steven C. Ricke

Computer Science and Computer Engineering Undergraduate Honors Theses

Bioinformatic analysis is a time-consuming process for labs performing research on various microbiomes. Researchers use tools like Qiime2 to help standardize the bioinformatic analysis methods, but even large, extensible platforms like Qiime2 have drawbacks due to the attention required by researchers. In this project, we propose to automate additional standard lab bioinformatic procedures by eliminating the existing manual process of determining the trim and truncate locations for paired end 2 sequences. We introduce a new Qiime2 plugin called TruncTrimmer to automate the process that usually requires the researcher to make a decision on where to trim and truncate manually after …


Developing A Microdialysis Sampling-Based Biofilm/Macrophage Co-Culture Model, Alda Diaz Perez May 2021

Developing A Microdialysis Sampling-Based Biofilm/Macrophage Co-Culture Model, Alda Diaz Perez

Graduate Theses and Dissertations

The host immune system and bacterial cells are known to interact during the human lifetime. Bacteria secrete a wide variety of signaling molecules, known as quorum sensing (QSC) molecules, that modulate the host immune system. While immune-biofilm interactions involve this chemical signaling network, the mechanisms through which this occurs are not well understood. This work aimed to develop a new method that can be used not only in vitro settings but also in vivo. The microdialysis sampling technique has widely been used in in vitro and in vivo settings in humans, mice, and rats for the collection of neuropeptides, cytokines, …