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Full-Text Articles in Life Sciences
The Synthesis And Evaluation Of 5-Phenyloxazolidines As Potential Cardiovascular Drugs, Tammy C. Wang
The Synthesis And Evaluation Of 5-Phenyloxazolidines As Potential Cardiovascular Drugs, Tammy C. Wang
Chemistry & Biochemistry Theses & Dissertations
Drugs such as adrenoceptor antagonists and certain centrally acting agents are known to lower blood pressure and thus serve as clinically useful antihypertensive agents. Norepinephrine 4, a natural ∝-adrenoceptor agonist, is the major agent associated with increased blood pressure in the periphery. Based on a careful structure-activity comparison, a series of substituted oxazolidines, 20, 21, 22 and 23, have been designed as possible antihypertensive candidates. Specifically, 22 and 23 have been synthesized to serve as potential norepinephrine antagonists.
Preliminary evaluation of these compounds indicated that they were not antihypertensive in nature. The more active compound, 23, …
Survival And Reproduction Of The Freshwater Grass Shrimp Palaemonetes Paludosus (Gibbes 1850) (Decapoda:Palaemonidae), In Saline Water, Brian Thomas Lowe
Survival And Reproduction Of The Freshwater Grass Shrimp Palaemonetes Paludosus (Gibbes 1850) (Decapoda:Palaemonidae), In Saline Water, Brian Thomas Lowe
OES Theses and Dissertations
To determine the effects of salinity on adult and larval survival, egg deposition, egg hatching and metamorphosis, shrimp were held in the laboratory and exposed to treatment salinities ranging from O to 35 ppt. Tests on adult survival indicate a 96 hour LC-50 between 30 and 35 ppt. Longer term tests on adult survival showed high mortality in salinities greater than 15 ppt. Shrimp became ovigerous in salinities of O - 20 ppt with egg hatching and metamorphosis limited to O - 5 ppt. Starved- larvae hatched from field captured ovigerous females in O ppt were able to metamorphose in …
Use Of 52Cr For The Quantitative Determination Of Red Cell Volume, Claude Michael Hanbury
Use Of 52Cr For The Quantitative Determination Of Red Cell Volume, Claude Michael Hanbury
Chemistry & Biochemistry Theses & Dissertations
Chromium-52 has recently been suggested for use as a new agent to label red cells for the in vivo quantitation of red cell volume (1). In this paper, the development and validation of a routine 52cr labeling procedure is described.
The accuracy, precision, and detection limits of chromium analysis by Zeeman effect atomic absorption spectroscopy was evaluated in the concentration range of 1 - 10 ug Cr/L.
Red cell chromium uptake was evaluated as a function of time, temperature, and concentration. Red cells labeled with a 2.5 mg/L chromium solution for 30 minutes at room temperature exhibited optimal label …
Reactions Of Aqueous Chlorine In The Gastric Fluid Of The Rat, Michael Gary Nickelsen
Reactions Of Aqueous Chlorine In The Gastric Fluid Of The Rat, Michael Gary Nickelsen
Chemistry & Biochemistry Theses & Dissertations
Gastric fluid was recovered from Sprague-Dawley rats that had been fasted for 24 hr or 48 hr and administered 4 mL deionized water. The protein, carbohydrate and chloride ion content of the gastric fluid was determined.
When gastric fluid is chlorinated with radiolabeled chlorine to concentrations between 323 and 375 mg/L, analyzed by high performance chromatography followed by liquid scintillation counting, as much as 59% of the radiolabeled chlorine was associated with organic components of the gastric fluid.
Model studies with the aromatic amino acids and the protein pepsin showed the formation of chlorinated analogs. Two chlorinated amino acid derivatives …