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Statistical Methods For Assessing Individual Oocyte Viability Through Gene Expression Profiles, Michael O. Bishop, John R. Stevens, S. Clay Isom

Conference on Applied Statistics in Agriculture

In vivo derived oocytes are held as the gold standard for viability, other known origination methods are sub-par by comparison. Due to the low-viability of oocytes originating from these alternate methods, research was conducted to determine and quantify the validity of these alternate origination methods. However, the larger question of viability is on the individual oocyte level. We propose and compare methods of measurement based on gene expression profiles (GEPs) in order to assess oocyte viability, independent of oocyte origin. The first is based on a previously published wRMSD quantification of GEP differences. We also consider three novel methods: a …