Life Sciences Commons^™

Co-Sensitization Of Dopamine And Serotonin Receptors Occurs In The Absence Of A Change In The Dopamine D1 Receptor Complex After A Neonatal 6-Ohda Lesion, Li Gong

Electronic Theses and Dissertations

To test whether SKF 38393 could ontogenetically sensitize dopamine (DA) D$\sb1$ receptors and whether this sensitization would be associated with biochemical changes, intact and neonatal 6-hydroxydopamine (6-OHDA)-lesioned rats (200 $\mu$g i.c.v.) were treated daily from birth with SKF 38393 (3.0 mg/kg i.p. x 28 days) or its vehicle. In DA D$\sb1$ neonatally sensitized 6-OHDA rats, enhanced locomotor responses were observed with the first SKF 38393 challenge dose (3.0 mg/kg i.p.) at 6 weeks. This response increased further with weekly SKF 38393 treatments. Enhanced stereotyped behaviors were seen in both lesioned and sensitized rats at 8 weeks. There was no change …

Validation Of A Bag Sampling Method For 1,3-Butadiene, Lori Eckenrode

Community & Environmental Health Theses & Dissertations

At this time there is no NIOSH approved means for bag sampling 1,3-butadiene. An attempt was made to use the application of cold (0°F) to inhibit the reactivity of the gas prior to analysis. The State of California Air Resources Board has an approved method for the gas chromatographic analysis of 1,3-butadiene from stationary sources. The method was utilized in the application of industrial hygiene monitoring of affected workers. The application of cold was found to be ineffective at inhibiting the highly reactive nature of 1,3-butadiene. Analyte losses were too great to classify the method as an accurate measure of …

Daubert's Significance, Thomas G. Field Jr., Colleen M. Keegan

RISK: Health, Safety & Environment (1990-2002)

The authors review and note the limited reach of Daubert v. Merrell Dow Pharmaceuticals. They also address its implications for concerned non-lawyers.

Regulate Pollution Or Land Use - Managing Toxic Air Contaminants In Southern California, Marc Dohan

RISK: Health, Safety & Environment (1990-2002)

A California air quality management district recently proposed to limit the location of potential receivers, in contrast with sources, of air toxics. The author argues that, although this particular proposal was later abandoned, it amounted to land use regulation. He also argues that such action usurps local control and is unwarranted.

Pesticide Use On Broccoli, Cabbage, Cauliflower And Peppers Grown In Connecticut: 1991, James J. Turner Ii, Candace L. Bartholomew

Storrs Agricultural Experiment Station

No abstract provided.

Effects Of Portuguese Man-Of-War (Physalia Physalis) Venom On Isolated Rabbit Atria, Wayne R. Bonlie

Loma Linda University Electronic Theses, Dissertations & Projects

The cardiac effects of Portuguese man-of-war venom were studied using isolated atria from rabbits. Venom added (7.1 µg protein/ml) to the bath solution stimulates heart rate 120% (P < 0.01) and increases contraction amplitude 308% (P < 0.001). Both effects are dependent on bath concentrations of venom and calcium. The increase in contraction amplitude is significantly attenuated by diltiazem (0.8 µM) and atenolol (10 µM). Atenolol, a β1-adrenergic antagonist, completely blocks the increase in heart rate. Dantrolene (10 µM) did not significantly block the venom's effects. Ryanodine binding increases in the presence of venom showing that the venom is not in competition for calcium channels on the sarcoplasmic reticulum. These results suggest that the venom acts on the sarcolemma to increase calcium permeability, thereby causing an increase in contraction amplitude and possibly causing β1-adrenergic stimulation.

Book Review, Allan M. Soobert

RISK: Health, Safety & Environment (1990-2002)

Review of: VALERIE M. FOGLEMAN, HAZARDOUS WASTE CLEANUP, LIABILITY AND LITIGATION: A COMPREHENSIVE GUIDE TO SUPERFUND LAW. (Quorum Books 1992) [320 pp.] Acronyms, index, preface, selected bibliography. LC 91-47999, ISBN 0-89930-647-0. [$59.95 cloth. 88 Post Road West; Westport CT 06881.)

Pesticide Use On Peaches And Pears Grown In Connecticut: 1991, James L. Turner Ii, Candace L. Bartholomew

Storrs Agricultural Experiment Station

No abstract provided.

Toxics Use Reduction: Pro And Con, Francine Laden, George M. Gray

RISK: Health, Safety & Environment (1990-2002)

With the Massachusetts Toxics Use Reduction Act as an example, important issues related to the goals and effectiveness of TUR are examined. The benefits as claimed by proponents are contrasted with shortcomings outlined by opponents in point-counterpoint style. Ultimately, the authors call for more balanced analysis.

Book Review, James R. Baum

RISK: Health, Safety & Environment (1990-2002)

Review of: MANAGEMENT OF HAZARDOUS AGENTS. Vol. 1: INDUSTRIAL AND REGULATORY APPROACHES. Vol. 2: SOCIAL, POLITICAL, AND POLICY ASPECTS. (Duane G. LeVine & Arthur C. Upton eds., Praeger 1992). Each volume contains: bibliography, series foreword, foreword, figures, notes, biographical references, tables, index. Vol. 1: [194 pp.] LC-92-167 ISBN 0-275-94322-4. Vol. 2: [188 pp.] ISBN 0-275-94323-2. [Cloth, each $49.95. 88 Post Road West; Westport CT 06881.]

Interim Report On Data And Methods For Assessment Of 2,3,7,8-Tetrachlorodibenzo-P-Dioxin Risks To Aquatic Life And Associated Wildlife, Steven P. Bradbury, Philip M. Cook, Russell J. Erickson, Robert L. Spehar, Gerald T. Ankney

Steven P. Bradbury

In April, 1991 the Administrator of the U.S. Environmental Protection Agency (EPA) announced that the Agency would conduct a scientific reassessment of the risk of 2,3,7,8-tetrachlorodibenzo-p-dioxin (hereafter referred to as TCDD), and similar chemicals, to human health and the environment. Since 1985, EPA has classified TCDD, which it considers the most potent known animal carcinogen, as a probable human carcinogen. Sources of TCDD in the environment were subsequently regulated on the basis of animal cancer rates extrapolated to doses associated with human exposures. Recently, consensus has developed that the toxic effects of TCDD appear to be mediated by its binding …

Treat It Right : Alternative Wastewater Systems That Protect Water Quality, Brian Kent

Maine Collection

Treat It Right : Alternative Wastewater Systems That Protect Water Quality

Maine Dept. of Environmental Protection : Maine Dept. of Economic & Community Development, February 1993.

"This handbook was prepared by Maine Tomorrow, a consulting firm in Hallowell. Maine. The handbook was researched, written and designed by Brian Kent; the primary editor and research associate was Alison Truesdale, and Wendy Mahoney did the wordprocessing and desk-top printing."

Connecticut River 2020 Project: Cost And Economic Impact Analysis, Center For Economic Development

Center for Economic Development Technical Reports

This project addresses the following issues:

1) Analysis of the cost of abating water pollution sources contaminating the Lower Connecticut River for the communities of Agawam, Chicopee, Holyoke, Ludlow, South Hadley, Springfield, and West Springfield.

2) Analysis of the impact of water pollution abatement measures on the economy of Hamden and Hampshire Counties.

3) Analysis of the impact of additional economic development on Hamden and Hampshire Counties resulting from an improved river resource.

4) Assessment and analysis of increased recreational activities resulting from a cleaner river resource.

The research was conducted by the Center for Economic Development at the University …

El Envenenamiento De Aves Por Plomo: Un Grave Problema Que Sí Tiene Solución, Aldemaro Romero Jr.

Publications and Research

No abstract provided.

Toxicokinetics And Metabolism Of Aniline And 4-Chloroaniline In Medaka (Oryzias Latipes), Steven P. Bradbury, Julia M. Dady, Patrick N. Fitzsimmons, Michelle M. Voit, Dean E, Hammermeister, Russell J. Erickson

Steven P. Bradbury

The in vivo toxicokinetics and in vitro hepatic microsomal metabolism of (14C)aniline and (14C)4-chloroaniline in medaka (Oryzias latipes) were investigated to provide a basis upon which to interpret the toxicological responses of small aquarium fish to aniline derivatives. During static aqueous exposures of up to 320 min, parent equivalents failed to reach steady state and results from depuration studies clearly demonstrated biphasic elimination. Due to low elimination rates, 40 to 20% of absorbed aniline and 4-chloroaniline doses, respectively, remained within the fish through 330 min postexposure. Based on an analysis of excreted metabolites, N-acetylation was the dominant route of in …

A Non-Invasive Neurotoxicity Assay Using Larval Medaka, Steven P. Bradbury, Dave Featherstone, Charles D. Drewes, Joel R. Coats

Steven P. Bradbury

We present a method for non-invasive electrophysiological analysis of rapid escape responses in intact, freely behaving larval medaka (Oryzias latipes) before and after short-term exposure to environmental toxicants. Recordings are obtained as a larval medaka swims in a small chamber of water above pairs of recording electrodes etched onto a printed circuit board. When the chamber is briefly vibrated by a sinusoidal pulse from a speaker attached to the grid, a stereotyped Mauthner cell-initiated escape response is evoked. The following parameters were quantified from recordings: 1) Mauthner axon conduction velocity, 2) delay between Mauthner axon spike and motoneuron spike in …

Plomo: El Enemigo Invisible. La Contaminación Por Plomo En Venezuela, Aldemaro Romero Jr., Roberto Prato Ochoa

Publications and Research

No abstract provided.

Biosynthesis In Vitro Of Some Neurotoxic Amino Acids In Lathyrus Species, Fumio Ikegami, Yu-Haey Kuo, Fernand Lambein, Isamu Murakoshi

The Thai Journal of Pharmaceutical Sciences

Two different forms of cysteine synthase (CSase) were purified from the grass pea (Lathyrus sativus), being separated by chromatography on DEAE-Sepharose Fast Flow or EAH-Sepharose 4B. Data on the substrate specificity show that both isoenzymes catalyse ...

An Evidence For Effective Utilization Of The Aerial Parts Of Licorice (Glycyrrhiza Uralensis), Isamu Murakoshi, Shi-Shan Jia, Chao-Mei Ma, Jin-Feng Qi, Fumio Ikegami, Toshitsugu Sato, Tatsuo Aizawa, Yuichi Fujii

The Thai Journal of Pharmaceutical Sciences

Several pharmacological activities, namely anti-platelet aggregatory activity and inhibitory effects on phosphodiesterase (PDE), angiotensin converting enzyme (ACE), 5-lipoxygenase (5-LOX), prostaglandin synthetase (PGS), trypsin (TSN), lipid peroxidatio...

Enzymic 12-Hydroxylation And 12-O-Methylation Of Dihydrochelirubine In Dihydromacarpine Formation By Thalictrum Bulgaricum, Lothar Kammerer, Wanchai De-Eknamkul, Meinhart H. Zenk

The Thai Journal of Pharmaceutical Sciences

Two novel enzymes, dihydrochelirubine-12-hydroxylase and SAM: 12-hydroxydihy drochelirubine-12-O- methyltransferase have been discovered in cell-free extracts of yeast-elicited Thalictrum bulgaricum VEL. cell cultures. Both enzymes are involved in the la...

Screening Of Enzyme Activities In Crude Drugs (I) — B-Glucuronidase In Scutellariae Radix —, Fumio Ikegami, Kaori Matsunae, Takashi Kurihara, Takeshi Yamamoto, Isamu Murakoshi

The Thai Journal of Pharmaceutical Sciences

B~Glucuronidase (GUS) activity in the crude drug, Scutellariae Radix, was assayed in line with the quality control of Kampo {Japanese herbal) medicines. GUS was purified to homogeneity in the purification steps including CM-Sepharose Fast Flow and clirom...

Anthraquinones From Xyris Indica, Nijsiri Ruangrungsi, Thatree Phadungcharoen, Suchada Suriyagan, Toshikazu Sekineb, Yuichi Fujiic, Isamu Murakoshi

The Thai Journal of Pharmaceutical Sciences

Three anthraquinones, chrysazin(l), 3-methoxychrysazin (2) and 3-hydroxy -chrysazin (3), have been isolated from theflowering heads of Xyris indica L. 3-Hydroxy -chrysazin ( 1,3,8-trihydroxy -9,10-anthracenedione) is new plant constituent. Antimicrobial ...

Constituents Of Atherolepis Pierrei, Sunee Chansakaow, Thatree Phadungcharoen, Nijsiri Ruangrungsi, Toshikazu Sekineb, Isamu Murakoshi

The Thai Journal of Pharmaceutical Sciences

Examination of the chloroform extract from the root of Atherolepis pierrei (Asclepiadaceae) revealed the presence of a long chain hydrocarbon, heptatriacontane together with an aromatic principle, 2-hydroxy-4-methoxy benzaldehyde and three triterpenoids,...

Characterization Of Anti-Tumor Immunity In Oyster Toadfish (Opsanus Tau), And The Effects Of 7,12 -Dimethylbenz(A)Anthracene On This Immune Response, Kenneth R. Seeley

Dissertations, Theses, and Masters Projects

Cell-mediated lysis of cultured tumor target cells by nonspecific cytotoxic cells (NCC) was examined in the oyster toadfish (Opsanus tau), an estuarine teleost. NCC activity was evaluated in cells taken from the head kidney, peripheral blood, spleen and peritoneal cavity. NCC activity was a property of plastic nonadherent cells which lacked phagocytic activity, indicating that in terms of their functional capacity, the cells which mediate nonspecific cytoxic immune responses in oyster toadfish do not appear to be monocytes or macrophages. However, light and electron microscopic examination of these cells revealed that morphologically, they resemble monocytes and macrophages. A new technique …

Anti-Dermatophyte Activities Of “Tea Seed Cake” And “Pegu-Catechu”, Fumio Ikegami, Toshikazu Sekine, Osamu Iijima, Yuichi Fujii, Siriporn Okonogi, Isamu Murakoshi

The Thai Journal of Pharmaceutical Sciences

16 species of Thai medicinal plants and two folk medicines were tested for their antimicrobial activities by the disc agar diffusion method. From the size of inhibition zone against Trichophyton mentagrophytes and T. rubrum, the anti-Dermatophyte activit...

ไภสัชคุรุ, N/A

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

Formulation Of Sustained Release Mosquito Larvicidal Preparations From Bacillus Sphaericus(การเตรียมผลิตภัณฑ์ฆ่าลูกนํ้ายุงออกฤทธิ์นาน จากเชื้อแบซิ..., Ruedee Saowakonth, Yupin Rungvejhavuttivittaya, Narong Sarisuta, Suthin Siripraiwan, Puangpen Suyanandana

The Thai Journal of Pharmaceutical Sciences

The mosquito larvicidal preparations of Bacillus sphaericus were formulated in the form of sustained release granules by using dibasic calcium phosphate, talc.Avicel PH 101, and ethylcellulose as carriers. The obtained products possessed satisfactorily l...

ไภษัชยคุรุ, N/A

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

The Development Of Dermatological Products From Some Thai Medicinal Plants; Part I. Family Labiatae, Siriporn Okonogi, Yanee Pongpaibul, Isamu Murakoshi, Toshikazu Sekine

The Thai Journal of Pharmaceutical Sciences

A comparative study of antimicrobial activities of Coleus amboinicus (I), Anisomeles indica (II), Ocimum sanctum (III), Ocimum basilicum (IV), and Mentha merdinah (V) have been carried out. The ethanol extracts and the essential oils obtained from these ...

Two New Isocoumarins From Xyris Indica, Nijsiri Ruangrungsi, Toshikazu Sekine, Thatree Phadungcharoen, Suchada Suriyagan, Isamu Murakoshi

The Thai Journal of Pharmaceutical Sciences

Two new isocoumarins named xyridin A and B were isolated from the chloroform extract of the flowering heads of Xyris indica (Xyridaceae). Their structures have been established as 3-n-propyl-6,7-(methylenedioxy)-1H-2- benzopyran-1-one and 3-(r-oxopropyl)...