Life Sciences Commons^™

Fetal Alcohol Effects: A Review Of The Current Literature And A Proposed Study Of The Possible Additive Effects Of Marihuana And Alcohol On The Fetus, Shirley Lange Kamp

Masters Theses

The purpose of this paper was to review the current state of knowledge regarding the effects of alcohol ingestion during pregnancy, to determine the specific issues that remain under speculation, and to develop a theoretical research design which might aid in determining the role, if any, of marihuana in compounding fetal alcohol effects.

The literature reviewed indicated that alcohol creates a continuum of fetal effects from mild abnormalities to the full fetal alcohol syndrome; current marihuana studies suggest possible adverse effects on the fetus. The research model was based on this evidence, the well documented usage of both drugs by …

Inhibition Of Synaptosomal Biogenic Amine Transport By A Diverse Group Of Neurotoxic Chemicals, William M. Bracken

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Synaptosomal membrane functions were monitored, after in vitro exposure to select environmental pollutants, in synaptosomal preparations originating from rat cerebral cortices. The uptake of NE and 5HT into the synaptosomes was monitored as was the K⁺-dependent phosphate activity of the membrane. CH₃HgCl, Hg(NO₃)₂, CdCl₂, diisopropylfluorophosphate (DFP), paraoxon, acrylamide and Kepone were the test chemicals whose effects were studied.

CH₃HgCl, Hg(NO₃)₂ and Kepone had the greatest inhibitory effects on NE and 5HT uptake. The concentrations producing 50 percent inhibition (IC₅₀) were 1.4 x 10 …

Leptophos Metabolism In The Rat: An In Vivo Study Of Oxidative Versus Conjugative Modes Of Metabolism, David Richard Hampson

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

The objectives of this research were to examine the metabolism in vivo of the pesticide leptophos in the rat under normal conditions and during inhibition of the mixed-function oxidases and during depletion of glutathione. Glutathione is a cofactor in the conjugation reactions of the glutathione-S-transferases. Both the mixed-function oxidase system and the glutathione-S-transferases have been shown to be important in the biotransformation of other organophosphate pesticides.

Urinary metabolites of leptophos were extracted, derivatized and subsequently analyzed by gas-liquid chromatography. The methods used to analyze for alkyl phosphonates were subject to several shortcomings and modifications of the original procedure were necessary. …

A Computer Simulation Study Of Blood Cholinesterase Inhibition In Parathion Treated Rats, Scott Christopher Hennes

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

A computer simulation model of blood cholinesterase inhibition in rats resulting from a single oral or dermal dose of parathion was developed and tested. The model consists of a set of non-linear differential equations describing the absorption, distribution and metabolism of parathion and the kinetics of inhibition and reactivation of erythrocyte and plasma cholinesterase. The equations are numerically integrated to produce the time-course of each of the cholinesterase activities of the blood. The model was tested for validity by a comparison of the activities predicted by the model to values determined experimentally in male rats. The model successfully simulated plasma …

The Effects Of Tri-O-Tolyl Phosphate (Totp) On The Immune System Of Mice, Craig R. Brinkerhoff

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

TOTP is a prevalent industrial and environmental contaminant which has been shown to be a neurotoxic agent. This study was undertaken to investigate the effects of this compound on the immune system. Several techniques were employed to test the humoral as well as cellular effects. Male Swiss Webster mice were administered by gastric gavage with three doses of TOTP (5, 50, and 500 mg/kg) and one dose TMTP (50 mg/kg) in corn oil once a week for 13 weeks. Control animals were given corn oil alone.

Lymphocyte transformation was determined on cultures of splenic cells obtained from animals sacrificed at …

Pesticide Exposure Studies: Direct And Indirect Detection Of Absorption Of 2,4-D And Pronamide Herbicides In The Guinea Pig And Occupationally Exposed Workers, Ibrahim A.R. Al-Jabery

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

A simple high pressure liquid chromatography procedure was used to determine 2,4-D and pronamide exposure in spraymen and their dermal absorption and excretion in guinea pigs.

Results of dermal application of these herbicides to guinea pigs demonstrated a strong correlation between the applied dermal dose and the urinary residue excretion over the dosage range tested. As the dosage was increased, the urinary excretion of residues was also increased. However, the excretion of 2,4-D amine mixture following dermal treatment of guinea pigs was prolonged as compared to that of pronamide.

Residue levels of these compounds were also determined to estimate skin …

Accumulation Of Formaldehyde And Its Relation To Postmortem Aging Of Non-Gadoid Fish Species, Mohamad A. Al-Kanhal

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Three non-gadoid fish species, trout (Cynoscion regalis), English sole (Paraophyrys vetulus) and Pacific red snapper (Scomber japonicus) have been tested for the recovery of trimethylamine oxide (TMAO), trimethylamine (TMA), dimethylamine (DMA), and formaldehyde (FA) during postmortem storage at 4°C and -5°C. TMAO, TMA, and DMA content was determined by measuring them as the salt derivative of picric acid. FA was determined by using the 3-Methyl-2-Benzothiazolinone hydrazone test.

In muscle tissue of red snapper and English sole, it was clear that initially TMAO decreased during storage at 4°C, while the amounts of TMA, DMA, and …

Sulfatides As Opiate Receptors: An Evaluation Of The Opiate Binding Potential Of Sulfogalactosylgylcerolipid, Darby Geoghegan Hand

Chemistry & Biochemistry Theses & Dissertations

Cerebroside sulfate (CS) has recently been shown to bind opiate drugs in a pharmacologically relevent manner and therefore satisfy the structural requirements of an opiate receptor. Seminolipid (SGG), a novel sulfated galactosyl. glycerolipid that has been isolated from the testes of a variety of mammals, may be viewed as a structural analog of CS. In view of this structural similarity, it is reasonable to presume that SGG may also bind opiate drugs. The isolation of SGG from boar testes was accomplished using silica gel dry column chromotography with a chloroform: methanol water solvent system. The structure and purity of the …

Stress, Neurotransmitters And Avoidance Acquisition, Daniel Leo Richardson

Dissertations

No abstract provided.

The Short And Long Term Effects Of Opiates On Myenteric Neurons, Peter J. Karras

Dissertations

No abstract provided.

Opiates And Neuro-Effector Transmission In The Mouse Vas Deferens: Intracellular Recordings Of Excitatory Junction Potentials, Lauren Vaile Vitek

Dissertations

No abstract provided.

The Influence Of Cardiac Sympathetics And Periods Of Ischemic Insult Upon Myocardial Blood Flow, Incidence Of Arrhythmia, Electrical Activity And Myocardial Infarction During Coronary Occlusion, Michael J. Barber

Dissertations

No abstract provided.

Diisopropyl Phosphofluoridate-Induced Antinociception, Gary Lee Koehn

Dissertations

No abstract provided.

Geophysical Surveys For Buried Waste Detection At The Idaho National Engineering Laboratory, U.S. Department Of Energy

All U.S. Government Documents (Utah Regional Depository)

This report describes a series of geophysical surveys performed at the Idaho National Engineering Laboratory (INEL). The main purpose of the surveys was to evaluate techniques, principally ground-penetrating radar, for detecting and mapping radioactive wastes buried in shallow trenches and pits.

Isolated Frog Brainstem Technique: Analysis Of Neural Correlates Of Mating Calling And Possible Use In Drug Studies, David Douglas Schaffer

Dissertations

No abstract provided.

Uptake, Distribution, Metabolism And Clearance Of Kepone By Channel Catfish (Ictalurus Punctatus), Peter A. Vanveld

Dissertations, Theses, and Masters Projects

No abstract provided.

Effects Of Organic Compounds On Amphibian Reproduction, Wesley J. Birge, Jeffrey A. Black, Robert A. Kuehne

KWRRI Research Reports

Aquatic toxicity tests were conducted with atrazine, carbon tetrachloride, chloroform, methylene chloride, trisodium nitrilotriacetic acid (NTA), and phenol. Each compound was administered to developmental stages of three to five amphibian species. Exposure was initiated at fertilization and maintained through 4 days posthatching. Test responses included lethality and teratogenesis. Different amphibian species exhibited varying degrees of tolerance to the selected compounds. Greatest tolerance usually was observed for the more broadly adapted semi-aquatic and terrestrial species (e.g., Bufo americanus, Bufo fowleri). The more sensitive amphibians usually included those species which normally are restricted to aquatic or moist habitats (e.g., Rana …

ทดสอบภูมิเดิมของท่าน, ศศิบุษบา สืบแสง

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

Determination Of Suifonamide Residues In Eggs(การสำรวจหาซัลโฟนาไมด์ที่ตกค้างในไข่), สุหร่าย สายศร, วินนา เหรียญสุวรรณ, ชัชวาลย์ ศรลัมภ์, วิไล ชื่นจิตรผ่อง, ปิยา บูรณศิริ, อารี สุขประเสริฐ, อุมา กิติยานี, อมร กิ่งเกตุ

The Thai Journal of Pharmaceutical Sciences

Sulfonamide residues in chicken eggs, duck eggs and guail eggs were determined by using the method of Tishler et al 1968. Twenty-five 100 grams samples of each kind of eggs were analyzed for the sulfonamide residues in both egg white and egg yolk fractio...

อะไรทำให้เกิดอาการหืด หอบ ? ลิวโคไตรอีน-ซี?, สุกัญญา นิมมานนิตย์

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

ประมวลบทคัดย่อ, N/A

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

ทดสอบภูมิเดิมของท่าน, N/A

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

ยากับการขาดวิตามิน, เรวดี ธรรมอุปกรณ์

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

วิทยาการเรื่องยา, สุนันท์ พงษ์สามารถ

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

ประมวลบทคัดย่อ, สินธุ์ชัย แก้วกิติชัย

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

Psychopharmacological Analysis Of Central Muscarinic And Nicotinic Receptors, Leonard T. Meltzer

Theses and Dissertations

Arecoline and nicotine are two psychoactive cholinergic alkaloids. Arecoline is primarily a muscarinic agonist while nicotine, at low doses, is a nicotinic agonist. The experiments in this dissertation investigated two major areas: (1) the role of different factors in the development of tolerance to the behavioral effects of arecoline and nicotine, and (2) the possible mechanism and site of action of the discriminative stimulus (DS) effects of arecoline and nicotine.

The role of dispositional and physiological factors comfiared to behavioral factors in the development of tolerance to the effects of arecoline and nicotine on operant behavior was assessed in Experiments …

Estimate Of The Total Weight Of Kepone In The Major Components Of The Molluscan Fauna Of The James River, Virginia, Dexter S. Haven, Reinaldo Morales-Alamo

Reports

Contamination of the James River in Virgin ia with the pesticide Kepone has resulted in its accumulation in the tissues of the fauna inhabiting the river. Most of the Kepone available to the biota in the river is associated with sediment s (Schneider and Dawson, 1978) and Haven and Morales-Alamo (1979) have shown that oysters and other bivalve molluscs accumulate Kepone in their tissues when exposed to the pesticide associated with sediments in suspension. It is of interest to compare the quantities of Kepone bound in James River sediments with the quantities bound in the molluscan fauna of the river.

คุณภาพของยาแอมพิซิลลิน จากสถานพยาบาล ในกรุงเทพมหานคร, สุทธาทิพย์ จันทรสกุล, เยาวภา ไวรักษ์สัตว์, บุญอรรถ สายศร

The Thai Journal of Pharmaceutical Sciences

The iodometric method recommended in the Code of Federal Regulations is used to determine the content of ampicillin in commercial ampicillin capsules dispensed to patients in hospitals and clinics. Among 39 Samples of 250 mg./ capsule, 18 Samples have 10...

ความก้าวหน้าในการศึกษาถึงโทษของขันฑสกร, ประโชติ เปล่งวิทยา, จิราพร ลิ้มปานานนท์

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

ข่าว, N/A

The Thai Journal of Pharmaceutical Sciences

No abstract provided.