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Full-Text Articles in Life Sciences
Virulence Of Drosophila C Virus Increased After A Host Shift And Serial Passage In Drosophila Hosts, Katie A. Johnson
Virulence Of Drosophila C Virus Increased After A Host Shift And Serial Passage In Drosophila Hosts, Katie A. Johnson
EWU Masters Thesis Collection
The outcomes of novel host-pathogen interactions are unpredictable but can result in epidemics or pandemics. Exploring the initial encounter between a pathogen and a novel host species can elucidate why some pathogens successfully infect and adapt on a novel host when others fail. Much of our understanding of host virulence after host shifts was developed using serial passage experiments (SPEs) in bacteria. Three accepted SPE generalities have emerged: virulence increases on the novel host, the evolved pathogen will become less able to infect its native host, and the pathogen experiences convergent evolution. This study tests the first two generalities using …
Characterization Of Helicobacter Pylori Srnas Hpnc2525, Hpnc2600, And Hpnc2645, Brandon M. Flatgard
Characterization Of Helicobacter Pylori Srnas Hpnc2525, Hpnc2600, And Hpnc2645, Brandon M. Flatgard
EWU Masters Thesis Collection
Helicobacter pylori is a common microaerophilic gram-negative bacterium that infects approximately 50% of the human population. Although all H. pylori infections result in inflammation of the gastric epithelium, only 10-15% of infections are symptomatic and progress to severe gastric diseases such as gastric and duodenal ulcers, MALT lymphoma and gastric cancer. Different disease outcomes are due in part to genetic variations among H. pylori strains. Helicobacter pylori strains with a genomic region called the cytotoxin-associated pathogenicity island (cagPAI) are associated with an increased risk of severe disease. The cagPAI region encodes a type IV secretion system that transports the CagA …
Helicobacter Pylori Gene Regulation By Virulence Region Located Srnas, Veronica Janette Albrecht
Helicobacter Pylori Gene Regulation By Virulence Region Located Srnas, Veronica Janette Albrecht
EWU Masters Thesis Collection
Approximately 50% of the human population is infected with Helicobacter pylori, which can lead to gastrointestinal diseases such as ulcers and gastric adenocarcinoma. Helicobacter pylori strains are genetically variable, and some contain a DNA region called the cytotoxin associated gene pathogenicity island (cagPAI) that encodes virulence factors. Gastrointestinal disease associated with H. pylori are more likely to occur in infections with cagPAI positive strains. Helicobacter pylori has few known transcriptional regulators, but still must regulate expression to survive a constantly changing environment. A mechanism to facilitate this regulation was revealed in a transcriptome analysis conducted by Sharma et al. (2010) …
Impact Of Chytrid Fungus Pathogen On The Skin Microbiome Of Frogs In Northern Idaho And Turnbull National Wildlife Refuge, Washington, Philip M. Campos
Impact Of Chytrid Fungus Pathogen On The Skin Microbiome Of Frogs In Northern Idaho And Turnbull National Wildlife Refuge, Washington, Philip M. Campos
EWU Masters Thesis Collection
Amphibians worldwide are under threat from the infectious disease chytridiomycosis, which is caused by the chytrid fungus Batrachochytrium dendrobatidis (Bd). Bd is associated with the population declines of an estimated 501 species, 90 of which are presumed or confirmed extinct, making this the greatest documented loss of biodiversity attributed to a disease. Researching the amphibian skin microbiome may provide solutions to conservation of amphibians. Two main relationships have been observed between Bd and the microbiome: 1) bacteria producing antifungal metabolites can inhibit Bd and improve survival against the disease and 2) infection by Bd is believed to affect the composition …