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The Relationship Between The Murine Primary Immune Response To Sheep Red Blood Cells & Heterosis, Russell Gailor
The Relationship Between The Murine Primary Immune Response To Sheep Red Blood Cells & Heterosis, Russell Gailor
Masters Theses & Specialist Projects
Two inbred strains of mice, BALB/c and C57BL, were crossbred to produce Fl hybrids. This breeding scheme ensured a high degree of genetic heterozygosity as exemplified by the fact that the average weight of the Fl hybrids at 10 weeks of age was 10.1 percent greater that that of their contemporaries in the inbred parental strains.
The three lines of mice were then challenged with a 0.5 ml intraperitoneal injection of two-percent sheep red blood cells (SRBC). After a 15-day period the mice were bled and their sera were microtitrated for anti-SRBC agglutinin and the titers statistically analyzed. The Fl …