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Full-Text Articles in Life Sciences

Characterization Of Fiber Intake, The Gut-Brain-Axis, And Glycemic Control In Nh Bhutanese Refugees, Brandy Moser Jan 2023

Characterization Of Fiber Intake, The Gut-Brain-Axis, And Glycemic Control In Nh Bhutanese Refugees, Brandy Moser

Master's Theses and Capstones

The gut microbiome has a significant influence on chronic diseases, potentially through mediating inflammation and the gut-brain axis, yet underlying pathways remain unclear. Microbiomes are highly variable and can be influenced by a variety of lifestyle and environmental factors, like diet and medication use. The study of both the composition and function of the gut microbiome is warranted, yet many gaps remain particularly in our knowledge about the gut microbiome function in the context of chronic diseases. Refugee groups in the US, such as the Bhutanese refugee population in New Hampshire, are at higher risk for chronic diseases but underrepresented …


The Relationship Between Alpha-Defensin 1 And Gut Microbiome Composition In A Population Of Bhutanese Refugee Adults With A High Prevalence Of Type 2 Diabetes, Daisha Alana Drake Jan 2023

The Relationship Between Alpha-Defensin 1 And Gut Microbiome Composition In A Population Of Bhutanese Refugee Adults With A High Prevalence Of Type 2 Diabetes, Daisha Alana Drake

Honors Theses and Capstones

The New Hampshire Bhutanese refugee population is disproportionately affected by obesity and metabolic disorders such as type 2 diabetes. The gut microbiome is important for overall human health, with high microbial richness and diversity being associated with reduced chronic inflammation and type 2 diabetes risk. Microbial richness and diversity have been shown to decrease in United States (U.S.) immigrant populations, but have not been measured in refugee populations. One of the anti-inflammatory functions of the gut microbiome is related to the production of short-chain fatty acids (SCFAs), which regulate pro-inflammatory cytokine production. Alpha-defensin 1 is an antimicrobial peptide that is …