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Post-Acute Brain Injury Urinary Signature: A New Resource For Molecular Diagnostics, Andrew K. Ottens, Jillian E. Stafflinger, Hailey E. Griffin, Richard D. Kunz, David X. Cifu, Janet P. Niemeier

Anatomy and Neurobiology Publications

Heterogeneity within brain injury presents a challenge to the development of informative molecular diagnostics. Recent studies show progress particularly in cerebrospinal fluid with biomarker assays targeting one or a few structural proteins. Protein-based assays in peripheral fluids, however, have been more challenging to develop in part due to restricted and intermittent barrier access. Further, a greater number of molecular variables may be required to inform on patient status given the multifactorial nature of brain injury. Presented is an alternative approach profiling peripheral fluid for a class of small metabolic by-products rendered by ongoing brain pathobiology. Urine specimens were collected for …