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Molecular and Cellular Neuroscience
Electronic Thesis and Dissertation Repository
HPA axis; parvocelluar neuroendocrine cells; prostaglandine E2; GABA; evoke inhibitory post synaptic currents
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Synaptic Mechanisms For The Hypothalamic-Pituitary-Adrenal Axis Activation By Prostaglandin E2, Zahra Khazaeipool
Synaptic Mechanisms For The Hypothalamic-Pituitary-Adrenal Axis Activation By Prostaglandin E2, Zahra Khazaeipool
Electronic Thesis and Dissertation Repository
The activation of the hypothalamic-pituitary-adrenal (HPA) axis during inflammation is mediated by prostaglandin E2 (PGE2) produced in the brain. However, how PGE2 recruits neuronal mechanisms for HPA axis activation remains unknown. Accumulating evidence indicates that GABA-mediated inhibitory synaptic transmission plays a major role in the HPA axis regulation. That is, GABAergic transmission constitutively constrains the excitability of parvocellular neuroendocrine cells (PNCs) in the paraventricular nucleus of the hypothalamus (the HPA axis output neurons); the removal from this inhibition (i.e. disinhibition) powerfully activates the HPA axis. My thesis examined the actions of PGE2 on GABAergic synaptic transmission to PNCs. Using patch …