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Articles 1 - 7 of 7
Full-Text Articles in Life Sciences
Inheritance Of Virulence In The Root Rot Pathogen Phytophthora Sojae, Sirjana Devi Shrestha
Inheritance Of Virulence In The Root Rot Pathogen Phytophthora Sojae, Sirjana Devi Shrestha
Electronic Thesis and Dissertation Repository
The oomycete Phytophthora sojae causes stem and root rot of soybean plants. The interaction of pathogen avirulence (Avr) and host resistance (R)-genes determine the disease outcome. The Avr3a mRNA transcript level is variable among P. sojae strains and determines virulence towards the R-gene Rps3a. To study the inheritance of virulence, genetic crosses and self-fertilizations were performed. A cross between P. sojae strains ACR10 and P7076 causes transgenerational gene silencing of Avr3a allele, and this effect is meiotically stable up to the F5 generation. However, test-crosses of F1 (Avr3aACR10/Avr3a …
Arabidopsis Chromatin Remodeler Brahma: Its Functional Interplay With Polycomb Proteins And The Ref6 Histone Demethylase, Chenlong Li
Electronic Thesis and Dissertation Repository
BRAHMA (BRM) is a SWI/SNF-type chromatin remodeling ATPase that plays an important role in regulation of gene expression. Tri-methylation of lysine 27 on histone H3 (H3K27me3) is a histone modification that is associated with transcriptionally repressed genes and catalyzed by Polycomb Group (PcG) proteins. BRM has been proposed to antagonize the function of PcG proteins but the underlying molecular mechanism is unclear. To understand how BRM regulates the function of PcG proteins during plant development, a genome-wide analysis of H3K27me3 in brm mutant was performed using chromatin immunoprecipitation followed by next generation sequencing (ChIP-seq). Loss of BRM leads to increased …
Early Mechanisms Of Retinal Degeneration In The Harlequin Mouse, Eric Dolinar
Early Mechanisms Of Retinal Degeneration In The Harlequin Mouse, Eric Dolinar
Electronic Thesis and Dissertation Repository
Retinal diseases are personally debilitating and expensive, yet many early disease mechanisms leading to their onset and progression remain poorly understood. The harlequin mouse is a model of human mitochondrial dysfunction and parainflammation leading to subsequent cerebellar and retinal degeneration. Diagnosis of retinal degeneration can be tracked in vivo and is associated with AIF dysfunction. Here, retinal dysfunction in the harlequin mouse was first quantified using electroretinography followed by assay of blood-retinal-barrier integrity and transcriptome alterations in young adulthood. Nonmetric multidimensional scaling of oscillatory potentials provided a novel, comprehensive assessment of inner-retinal health and can detect shifts in OP parameters. …
Associations Between Hypothalamic-Pituitary-Adrenal Axis System Gene Variants And Cortisol Reactivity In Preschoolers: Main Effects And Gene-Environment Interactions, Haroon I. Sheikh
Electronic Thesis and Dissertation Repository
Exposure to stressful events during early development has consistently been shown to produce long lasting effects on the hypothalamic-pituitary-adrenal (HPA) axis, which may increase vulnerability to mood and anxiety disorders. Recently reported genetic association studies indicate that these disorders may be influenced, in part, by gene-environment interactions (GxE) involving polymorphisms within the corticotrophin-releasing hormone and monoaminergic system genes. However, little is known about how genetic variants and life stress work to shape children’s neuroendocrine reactivity and emerging symptoms. Therefore, the aim of this thesis is to examine main effects of candidate genes and GxE on the neuroendocrine stress response and …
Role Of Nitric Oxide In Embryonic Heart Development And Adult Aortic Valve Disease, Yin Liu
Role Of Nitric Oxide In Embryonic Heart Development And Adult Aortic Valve Disease, Yin Liu
Electronic Thesis and Dissertation Repository
Congenital heart disease (CHD) is the most common birth defect in infants. Identifying factors that are critical to embryonic heart development or CHDs in general could further our understanding of the disease and may lead to new strategies of its prevention and treatment. Endothelial nitric oxide synthase (NOS3/eNOS) is known for many important biological functions including vasodilation, vascular homeostasis and angiogenesis. Previous studies have shown that deficiency in NOS3 results in congenital septal defects, cardiac hypertrophy and postnatal heart failure. In addition, NOS3 is pivotal to morphogenesis of aortic valve and myocardial capillary development. The aim of my thesis was …
Arabidopsis Thaliana-Spider Mite Interaction: Plant Perception, Signalling, And Response, Kristie A. Bruinsma
Arabidopsis Thaliana-Spider Mite Interaction: Plant Perception, Signalling, And Response, Kristie A. Bruinsma
Electronic Thesis and Dissertation Repository
The two-spotted spider mite, Tetranychus urticae, is a cell-content feeding chelicerate herbivore, feeding on over 1000 plant species, one of which is Arabidopsis thaliana. This research uses microarray data from two A. thaliana accessions that differ in susceptibility to spider mite feeding to identify how the plant defends itself against this herbivore. Mutant analysis of induced plant defense pathways and physiological assays of mite performance indicate that A. thaliana utilizes: a) damage associated molecular pattern receptors, PEPR1 and PEPR2, to aid in perception of attack; b) jasmonic acid as the key phytohormone involved in resistance signalling; and c) …
Maternal Control Of Genomic Imprinting: Effects Of Infertility And Ovarian Stimulation In A Mouse Model, Michelle M. Denomme
Maternal Control Of Genomic Imprinting: Effects Of Infertility And Ovarian Stimulation In A Mouse Model, Michelle M. Denomme
Electronic Thesis and Dissertation Repository
Gametogenesis and early embryogenesis are important stages in which genome-wide epigenetic transitions required for early mammalian development are orchestrated. This is exemplified by the occurrence of genomic imprinting, where epigenetic mechanisms lead to the monoallelic expression of a subset of genes. Parental-specific DNA methylation in the gametes results in the distinct nonequivalence of the parental genomes in the early embryo. Changes from normal gamete and embryo development by impaired fertility or assisted reproductive technologies (ARTs) may disrupt the processes of imprint acquisition and imprint maintenance. My hypothesis is that aberrant imprinted methylation arises from impaired maternal fertility or ovarian stimulation …