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Full-Text Articles in Life Sciences
Bispecific Anti-Hiv Immunoadhesins That Bind Gp120 And Gp41 Have Broad And Potent Hiv-Neutralizing Activity, Seth H. Pincus, Ryan B. Craig, Lauren Weachter, Celia C. Labranche, Rafiq Nabi, Connie Watt, Mark Raymond, Tami Peters, Kejing Song, Grace A. Maresh, David C. Montefiori, Pamela A. Kozlowski
Bispecific Anti-Hiv Immunoadhesins That Bind Gp120 And Gp41 Have Broad And Potent Hiv-Neutralizing Activity, Seth H. Pincus, Ryan B. Craig, Lauren Weachter, Celia C. Labranche, Rafiq Nabi, Connie Watt, Mark Raymond, Tami Peters, Kejing Song, Grace A. Maresh, David C. Montefiori, Pamela A. Kozlowski
School of Graduate Studies Faculty Publications
We have constructed bispecific immunoglobulin-like immunoadhesins that bind to both the HIV-envelope glycoproteins: gp120 and gp41. These immunoadhesins have N terminal domains of human CD4 engrafted onto the N-terminus of the heavy chain of human anti-gp41 mAb 7B2. Binding of these constructs to recombinant Env and their antiviral activities were compared to that of the parental mAbs and CD4, as well as to control mAbs. The CD4/7B2 constructs bind to both gp41 and gp140, as well as to native Env expressed on the surface of infected cells. These constructs deliver cytotoxic immunoconjugates to HIV-infected cells, but not as well as …
Unraveling Host-Gut Microbiota Dialogue And Its Impact On Response To Immune Checkpoint Blockade, Alexandria Cogdill
Unraveling Host-Gut Microbiota Dialogue And Its Impact On Response To Immune Checkpoint Blockade, Alexandria Cogdill
Dissertations & Theses (Open Access)
Cancer is a disease with only one degree of separation, affecting one in two men and one in three women in their lifetimes; accounting for 1 of every 6 deaths. While cancer mortality rates continue to improve, incidence rates are expected to rise and shift through 2050 due to epidemiological and demographic transitions worldwide. As such, it is imperative to continue to investigate and improve our understanding of both disease etiology and hallmarks of response to treatment. Currently, conventional therapies include, but are not limited to, surgery, chemotherapy, and radiotherapy. However, within the past decade, major advances have been made …
A Literature Review On Tumor Microenvironmental Immunosuppressive Mechanisms On Cd8+ T Lymphocytes That Contribute To Tumor Immune Evasion, Jessica R. Gabrysiak
A Literature Review On Tumor Microenvironmental Immunosuppressive Mechanisms On Cd8+ T Lymphocytes That Contribute To Tumor Immune Evasion, Jessica R. Gabrysiak
Honors Projects
The concept of tumor immune evasion is a prevalent obstacle in cancer research and the development of immunotherapies. Increased insight into mechanisms that are responsible for the escape of cancer cells from the immune system will help to improve therapeutic approaches and provide understanding into slowing disease progression by utilizing the body's immune system. With immunotherapy development on the forefront of cancer research due to seemingly attenuated toxicity and resistance when compared to traditional chemoradiotherapy, analyzing these obstacles is essential for emerging roles and future directions in the discipline of immuno-oncology. Understanding the immunosuppressive molecules that contribute to the process …