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Bluetongue Virus Evolution: Sequence Analyses Of The Gene Coding For The Major Serogroup Antigen, Timothy F. Kowalik
Bluetongue Virus Evolution: Sequence Analyses Of The Gene Coding For The Major Serogroup Antigen, Timothy F. Kowalik
All Graduate Theses and Dissertations, Spring 1920 to Summer 2023
A study was undertaken to better understand the genetic relationship of five United States prototype bluetongue virus serotypes. Genomic double-stranded RNA segment S1, which encodes the major core protein and serogroup antigen, VP7, was used as a marker gene for the sequence analyses. The S1 segments from BTV-2, 11, 13, and 17 were cloned and sequenced by methods developed during the course of this investigation. These results were compared with previously published sequence data from segment S1 of BTV-10. The Sl segments are 1156 base pairs long and contain a common open reading frame capable of coding for a protein …