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Articles 1 - 6 of 6
Full-Text Articles in Life Sciences
Impact Of Probiotics On Black Soldier Fly Larvae Transmission Of Stenotrophomonas Maltophilia, Emily Marie Mclaughlin
Impact Of Probiotics On Black Soldier Fly Larvae Transmission Of Stenotrophomonas Maltophilia, Emily Marie Mclaughlin
Honors College
Stenotrophomonas maltophilia is an opportunistic pathogen which can cause a variety of infections, especially in immunocompromised individuals. It has recently been found that black soldier flies can act as carriers for S. maltophilia (Callegari et al., 2020). I have investigated how probiotics impact their vector capabilities. Black soldier fly larvae have been fed substrate spiked with S. maltophilia. After several days of feeding, the larvae were investigated by PCR and plating (Sveensson-Stadler et al., 2011). Two groups of larvae were fed with potatoes infected with S. maltophilia. Persistence of S. maltophilia was determined using PCR by taking samples …
Infection And Diet-Induced Gut Dysbiosis: Impact On Sleep Quality In Danio Rerio, Benjamin Williams
Infection And Diet-Induced Gut Dysbiosis: Impact On Sleep Quality In Danio Rerio, Benjamin Williams
Honors College
A known bidirectional relationship between intestinal microflora and the central nervous system, coined the gut-brain-axis, has stimulated work on the association between gut dysbiosis and inflammation, and sleep quality. Previous studies in the Hayes Lab have reported that a high fat (HF) diet was correlated with immobile phases, a marker of low motility during sleep found in some neurological disease and sleep duration[1]. Long sleep duration (>1 S.D. above norms for age) is associated with poor sleep quality or sleep fragmentation in participants who are overweight or obese according to body mass index values[2]. The current work utilizes a …
The Role Of Accessory Domain In Cpsa Function And Capsule Production In Group B Streptococcus, Gina Difederico
The Role Of Accessory Domain In Cpsa Function And Capsule Production In Group B Streptococcus, Gina Difederico
Honors College
Group B Streptococcus (GBS) can be found in the vaginal and genitourinary tract of females, as well as the genitourinary tract of males, where it behaves as a commensal organism. However, as an opportunistic pathogen, GBS has the capability to infect the immunocompromised, making it a major threat to neonates and fetuses. The pathogen can be passed from mother to baby either in utero or during birth. The capsule, which is a polysaccharide coating on the outside of the cell, is considered the most important virulence factor in GBS.Expression of capsule plays a role in evasion of the host immune …
Understanding The Role Of Prophage Encoded Polymorphic Toxins In Mycobacterial Superinfection Immunity And Drug Resistance, Dakota Archambault
Understanding The Role Of Prophage Encoded Polymorphic Toxins In Mycobacterial Superinfection Immunity And Drug Resistance, Dakota Archambault
Honors College
Mycobacterium abscessusis the leading cause of lung infection in cystic fibrosis patients and is often resistant to all antibiotics. There is an urgent need for alternative therapies such as lytic bacteriophage (viruses that infect bacteria). Phage therapy has been successful in the treatment of a drug-resistantM. abscessusinfection in a teenaged cystic fibrosis patient but there are challenges to broad use as most M. abscessusisolates are highly resistant to lytic bacteriophage infection. Prophage, or integrated bacteriophage genomes within the M. abscessusgenome, likely defend against phage superinfection via prophage-encoded viral defense systems. The Molloy lab has shown that the Mab cluster R …
An Investigation Of The Relationship Between Black Soldier Fly Larvae Pathogen Suppression And Growth Substrate In Relation To Maine Agricultural Industries, Haley Morrill
Honors College
Insects are promoted as cost-effective and sustainable protein sources for animal feed. Their utilization may help to avoid a predicted global protein shortage. Black soldier fly (Hermetia illucens) larvae (BSFL) grow on organic wastes, converting these wastes into larval biomass which can fulfill this purpose. Potential benefits of using BSFL to remediate organic wastes include reduction of waste mass and bacterial load, along with the sale of larvae as a protein supplement. BSFL suppress the growth of some Gram-positive and Gram-negative human pathogens in these substrates; though suppression of Bacillus cereus, a spore-forming bacterium that causes food-poisoning, …
Characterizing The Diversity Of Cluster R Prophage In Mycobacterium Abscessus, Colin Welch
Characterizing The Diversity Of Cluster R Prophage In Mycobacterium Abscessus, Colin Welch
Honors College
Mycobacterium abscessus is a mycobacterial pathogen responsible for pulmonary and disseminated infections in susceptible individuals and often is resistant to all antibiotic therapies, with cure rates ranging from 25% to 58% (Degiacomi et al., 2019).Investigating the mechanisms of extensive resistance in M. abscessus lends opportunities to develop more effective treatments. Prophage, viral sequences integrated into bacterial genomes, contribute to virulence and fitness in many bacterial pathogens including Escherichia coli O157:H7 and Vibrio cholerae (Fortier & Sekulovic, 2013). Yet, prophage in pathogenic mycobacteria are not well understood or studied. Recent work has demonstrated that the Mycobacterium chelonae prophage, McProf can function …