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Network And Ecological Methods To Study Enteric Pathogen Co-Infections, Connor L. Klopfer
Network And Ecological Methods To Study Enteric Pathogen Co-Infections, Connor L. Klopfer
Graduate College Dissertations and Theses
Diarrhea remains a leading cause of childhood morbidity and mortality, especially inchildren under 5 years of age. Enteric pathogen co-infection has been found to cause increased diarrheal severity and some pathogens may work in tandem to enhance infection. It is important to identify patterns of pathogen co-infection and their impact on diarrhea to inform intervention strategies for improving child health. In this thesis, I use data from the MAL-ED and PROVIDE birth cohort studies in Bangladesh to generate bipartite networks that represent the relationship between stool samples and pathogens. I randomly rewire the network while preserving connectivity to randomize the …