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Recently Evolved Francisella-Like Endosymbiont Outcompetes An Ancient And Evolutionarily Associated Coxiella-Like Endosymbiont In The Lone Star Tick (Amblyomma Americanum) Linked To The Alpha-Gal Syndrome, Deepak Kumar, Surendra Raj Sharma, Abdulsalam Adegoke, Ashley Kennedy, Holly C. Tuten, Andrew Y. Li, Shahid Karim
Recently Evolved Francisella-Like Endosymbiont Outcompetes An Ancient And Evolutionarily Associated Coxiella-Like Endosymbiont In The Lone Star Tick (Amblyomma Americanum) Linked To The Alpha-Gal Syndrome, Deepak Kumar, Surendra Raj Sharma, Abdulsalam Adegoke, Ashley Kennedy, Holly C. Tuten, Andrew Y. Li, Shahid Karim
Faculty Publications
Background: Ticks are hematophagous arthropods that transmit various bacterial, viral, and protozoan pathogens of public health significance. The lone star tick (Amblyomma americanum) is an aggressive human-biting tick that transmits bacterial and viral pathogens, and its bites are suspected of eliciting the alpha-gal syndrome, a newly emerged delayed hypersensitivity following consumption of red meat in the United States. While ongoing studies have attempted to investigate the contribution of different tick-inherent factors to the induction of alpha-gal syndrome, an otherwise understudied aspect is the contribution of the tick microbiome and specifically obligate endosymbionts to the establishment of the alpha-gal …