Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 1 of 1
Full-Text Articles in Life Sciences
Characterizing The Role Of Hspb2 In Cardiac Metabolism And Muscle Structure Using Yeast And Mammalian Systems, Jonathan Paul Neubert
Characterizing The Role Of Hspb2 In Cardiac Metabolism And Muscle Structure Using Yeast And Mammalian Systems, Jonathan Paul Neubert
Theses and Dissertations
HspB2 is a small heat shock protein encoded on human chromosome 11. Less than 1000 base pairs away from HSPB2 and situated in a head-to-head orientation lies the gene encoding another small heat shock protein, CRYAB. Because they are uncommonly close to one another they share regulatory elements. In addition, they share protein homology as sHSPs, suggesting that they perhaps perform aimilar functions. SHSPs such as HspB2 and CryAB are traditionally thought to provide protective effects to cells in response to a variety of stress inducers. In response to stress they form complexes around misfolded proteins or proteins in danger …