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The Role Of Caveolin In The Toll-Like Receptor (Tlr) Signaling Pathway, Richard H. Luc
The Role Of Caveolin In The Toll-Like Receptor (Tlr) Signaling Pathway, Richard H. Luc
Honors College
Upon viral infection, the host’s immune system can induce the antiviral state to protect from further infection. In this antiviral state, RNA synthesis and protein synthesis are downregulated, and viral replication is inhibited (Kawai and Akira, 2006). Two of the key pathways critical to establishing the antiviral state include the Toll-like receptor (TLR) and the interferon (IFN) receptor (IFNR) pathways (Kawai and Akira, 2006). The TLR pathway is critical to recognizing viral components, while the IFNR pathway is vital to activating genes necessary for inducing the antiviral state. As the host evolves to combat viral infections, viruses have also evolved …