Life Sciences Commons^™

Cosmetic Outcome As Rated By Patients, Doctors, Nurses And Bcct.Core Software Assessed Over 5 Years In A Subset Of Patients In The Targit-A Trial, Tammy Corica, Anna K. Nowak, Christobel M. Saunders, Max K. Bulsara, Mandy Taylor, Norman R. Williams, Mohammed Keshtgar, David J. Joseph, Jayant S. Vaidya

Health Sciences Papers and Journal Articles

Background: The purpose of this research was to assess agreement between four rating systems of cosmetic outcome measured in a subset of patients with early breast cancer participating in the randomised TARGIT-A trial. TARGIT-A compared risk-adapted single-dose intra-operative radiotherapy (TARGIT-IORT) to whole breast external beam radiotherapy (EBRT).

Methods: Patients, their Radiation Oncologist and Research Nurse completed a subjective cosmetic assessment questionnaire before radiotherapy and annually thereafter for five years. Objective data previously calculated by the validated BCCT.core software which utilizes digital photographs to score symmetry, colour and scar was also used. Agreement was assessed by the Kappa statistic and longitudinal …

Environmental And Social Benefits Of The Targeted Intraoperative Radiotherapy For Breast Cancer: Data From Uk Targit-A Trial Centres And Two Uk Nhs Hospitals Offering Targit Iort, N Coombs, J Coombs, U Vaidya, J Singer, M Bulsara, J Tobias, F Wenz, D Joseph, D Brown, R Rainsbury, T Davidson, D Adamson, S Massarut, D Morgan, I Potyka, T Corica, M Falzon, N Williams, M Baum, J Vaidya

Health Sciences Papers and Journal Articles

Objective: To quantify the journeys and CO2 emissions if women with breast cancer are treated with risk-adapted single-dose targeted intraoperative radiotherapy (TARGIT) rather than several weeks’ course of external beam whole breast radiotherapy (EBRT) treatment.

Setting: (1) TARGIT-A randomised clinical trial (ISRCTN34086741) which compared TARGIT with traditional EBRT and found similar breast cancer control, particularly when TARGIT was given simultaneously with lumpectomy, (2) 2 additional UK centres offering TARGIT.

Participants: 485 UK patients (249 TARGIT, 236 EBRT) in the prepathology stratum of TARGIT-A trial (where randomisation occurred before lumpectomy and TARGIT was delivered simultaneously with lumpectomy) for whom geographical data …

The Effect Of Exercise Intensity On Physiological And Psychological Outcomes In Breast And Prostate Cancer Survivors: A Controlled Study, Eric Martin

Theses

Introduction

Research has identified a need to explore the components of exercise prescription for cancer survivors, particularly the most effective exercise intensity. The main purpose of this research was to examine whether exercise intensity modulates a range of physiological and psychological outcomes for breast and prostate cancer survivors. The primary outcomes were related to peak oxygen consumption (VO2peak) and quality of life (QOL). VO2peak is a highly sensitive measure that indicates overall health. QOL references the general wellbeing of individuals, and is an outcome of great importance in cancer rehabilitation research.

Pilot Study

A pilot study involving breast cancer survivors …