Life Sciences Commons^™

The Effect Of Orally Administered Butylated Hydroxytoluene On Herpes Simplex Keratitis, Donald Carson

Masters Theses & Specialist Projects

Some studies have reported in vitro inactivation of membrane enveloped viruses by Butylated hydroxytoluene (BHT). This study investigates the effect of orally administered BHT on primary infections of Herpes simplex virus (HSV) using rabbit corneas as the assay system.

Assigned levels of BHT were incorporated into the diet of New Zealand White rabbits with HSV-1 McKrae strain on the corneal surface of the eyes. The degree of infection was measured by a subjective assay. Rabbits receiving BHT in their diet consistently experienced lower levels of infection. The interpretation of this data is that orally administered BHT can be an effective …

Human Performance Lab Newsletter, Vol 4, No. 1, St. Cloud State University

Human Performance Lab Newsletter

Contents of this issue includes:

• The Glory in Mediocrity by George Sheehan
• Proper and Improper Weight Loss
• More on Smoking
• On Drinking
• The Danger of Sedentary Lifestyles

Identification Of Four Complementary Rna Species In Akabane Virus-Infected Cells, Asit K. Pattnaik, G. Abraham

School of Veterinary and Biomedical Sciences: Faculty Publications

The analysis of RNA extracted from purified Akabane virus demonstrated the presence of three size classes of single-stranded RNAs with sedimentation coefficients of 31S (large, L), 26S (medium, M), and 13S (small, S). Molecular weights of these RNA species were estimated to be 2.15 x 10⁶,1.5 X 10⁶, and 0.48 x 10⁶ for the L, M, and S RNAs, respectively. Hybridization analysis involving viral genomic RNA and RNA from virus-infected cells resulted in the identification of four virus-specific cRNA species in infected cells. These cRNAs were found to be nonpolyadenylated by their inability to bind …

Recombinant Immune Interferon Increases Immunoglobulin G Fc Receptors On Cultured Human Mononuclear Phagocytes, Paul M. Guyre, Peter M. Morganelli, Renee Miller

Dartmouth Scholarship

Although recent studies suggest that interferons can increase the number of IgG Fc receptor (FcR gamma) sites on mouse macrophages, direct assessment of similar effects on human mononuclear phagocytes is lacking. We therefore measured the specific binding of 125I- and fluorescein-labeled IgG1 to human monocytes and leukemic cell lines after culture in vitro with highly purified human interferons. We report that natural and recombinant human gamma-interferon causes a dramatic (nearly 10-fold) increase in the number of FcR gamma on normal human monocytes and on the human cell lines HL-60 and U-937. Alpha and beta-interferons cause a modest but significant increase …

Human Performance Lab, Vol. 3, No. 1, St. Cloud State University

Human Performance Lab Newsletter

Contents of this issue include:

• Minnesota Life Expectancy Beats the Nation
• Lowering the Slope of the Hill
• Where There's Smoke, There's a Rat! By Art Buchwald
• Rise and Shine by Bev Oehrlein, Graduate Assistant

Evidence For Hydrated Spermidine-Calf Thymus Dna Toruses Organized By Circumferential Dna Wrapping, Kenneth A. Marx, George C. Ruben

Dartmouth Scholarship

In spermidine-condensed calf thymus DNA preparations, torus–shaped condensates were shown by transmission electron microscopy to exist under the hydrated conditions of the freeze fracture experiment. Using extremely low Pt metal deposition levels (9 A Pt/C) high–contrast replicas of the spermidine–DNA toruses were obtained that showed circumferential wrapping of single DNA double helix–size surface fibres. Stereoscopic analysis of high magnification stereomicrographs established some details of the three-dimensional organization of two DNA double helix sections winding circumferentially on the inner surface of one such torus. These measurements demonstrate the usefulness of stereoscopic analysis of these high macromolecular organization magnification. Measurements on a …

Foliar Diseases Of Wheat, A. G. P. Brown

Experimental Summaries - Plant Research

Leaf disease in the wheatbelt. Wheat leaf diseases were common north of Perth. They were severe in the Moora district and catastrophic in the northern wheatbelt. Yellow spot (Pyrenophora tritici-repentis) and glume blotch (Septoria nodorum) were the major pathogens in most areas with yellow spot exceeding glume blotch in area of leaf affected for the first time since surveys began in 1971. In the south dry conditions prevailed and diseases were hard to find. Figure 1 gives the distribution in the various zones for 1983 excluding the Esperance district which was not surveyed. Stress damage induced mostly by water stress …

Barley Foliage Diseases, T N. Khan, K. Brain, M Judges

Experimental Summaries - Plant Research

General comments and highlights

Scald: Effect of time of application - 83BA10, 83MT9.

Scald: Effect of rate of fungicide – 83BA11.

Scald: Comparing fungicides – 83BA42.

Scald: Effect of seeding rate – 83BA12, 83MT10.

Scald: Response to fungicide in farmer's field – 83AL18, 83AL81, 83AL82.

Scald: Variation in pathogenicity – 83AB11, 83BA13, 83MT11, 83WH7.

Scald: Cultivar x fungicide in farmer's field – 83LG63.

Net Blotch: Potential yield losses – 83A15, 83BA15, 83WH6.

Net Blotch: Screening new fungicides – 83BA43.

Spot-type net blotch: Potential yield losses – 83C5.

Spot-type net blotch: Sources of resistance - Chapman Research Station, Nabawa.

Powdery mildew …

Plant Viruses, G D. Mclean

Experimental Summaries - Plant Research

1. Alfalfa mosaic virus: incidence in white clover. McLean, G.D., Weir, J.A., Russell, W.K., Speijers, E.J. and Price, L.K. - 83HA30, 83HA31, 83HA32, 83HA33, 83HA34, 83HA35, 83HA36, 83HA37, 83HA38, 83HA39. 2. Alfalfa mosaic virus: re-infection in white clover. McLean, G.D., Weir, J.A., Russell, W.K., Price, L.K. and Speijers, E.J. – 83HA43, 43HA44, 43HA45, 43HA46, 83HA47, 83HA48, 83HA49, 83HA50, 83HA51, 83HA52. 3. Lettuce necrotic yellows virus: incidence. McLean, G.D., Phillips, D.R., Speijers, E.J. Sandow, J.S. and Price, L.K. – 83PE21, 83PE22, 83PE23, 83PE24, 83PE25, 83PE26, 83PE27, 83PE28, 83PE29, 83PE30.

Lupin Diseases, P Mcr Wood

Experimental Summaries - Plant Research

Fungicide treatment of lupin seed - 83GE45, 83GE46, 83GE47. Fungicide treatment of lupin seed in polyculture - 83NO48, 83BU21. Levels of Pleiochaeta in different organic fractions - 83AL51 (2 sites). Phomopsis levels on post-harvest samples - 83AL51.

Thoughtful Use Of Animals, Hyram Kitchen

Experimentation Collection

As part of a symposium held in Cincinnati entitled, "Ethical Issues Related to the Use of Research Animals," I was asked by the program director to consider whether further legislation regarding the use of animals might be necessary to ensure more thoughtful use of animals at universities. The following is my response.

Alternatives To Animal Experimentation, Steven M. Niemi

Experimentation Collection

Alternatives to animal experimentation are highly touted today by animal welfare advocates. Their campaign for adoption of alternatives has caused much discussion and debate within and outside of the biomedical community. The purpose of this paper was to examine the controversy and assess the more common alternatives, including the bacterial mutagenicity assay or Ames test, cell culture, and mathematical models for toxicity prediction. Safety testing of chemicals is the most promising of the fields for alternatives where laboratory animals are used, and incorporation of alternatives with live-animal assays is increasing. However, due to limitations of alternatives in use currently, there …

Review Of Literature On Use Of T-61 As An Euthanasic Agent, Laura Dalia Barocio

Veterinary Science and Medicine Collection

The tools of evaluating the degree of distress in animals being killed include electroencephalography (EEG), electrocardiography (ECG), and measurement of blood pressure and respiration. Sound clinical and behavioral observations should also not be abandoned in the evaIuation process.

There are many methods which may be employed to reach the same end results, but the ideal method should satisfy several criteria: 1. It should be painless; 2. It should cause unconsciousness instantaneously and death within minutes; 3. It should not cause undue anxiety, alarm, fear, panic, behavior, struggling, vocalization, muscle spasms or clinical signs of automatic activation (e.g., convulsions) before unconsciousness; …

Psychology And Its Animal Subjects, Kenneth J. Shapiro

Experimentation Collection

By way of introducing Psychologists for the Ethical Treatment of Animals (PsyETA) to readers of the journal, I have been asked to make some comments about the organization and, from a personal point of view, to suggest some of my own positions and views.

Protection Of Animals And Animal Experimentation: A Survey Of Scientific Experts, Norbert Lagoni, Joachim Fiebelkorn, Hans-Joachim Wormuth

Experimentation Collection

This article summarizes information from a survey of biomedical scientists, specifically pharmacologists and toxicologists, on the use of laboratory animals and the potential for replacing their use with alternative methods for the development and evaluation of pharmaceutical substances. The majority of those surveyed felt that the alternatives could supplement or complement animal tests, but not replace the tests altogether. However, most favored the use of nonsentient material in safety tests.

A Survey Of Animal Behavior-Related Research And Teaching Activities In North American Agricultural And Veterinary Medical Colleges, W. R. Stricklin

Ethology Collection

A letter questionnaire was used to survey animal behavior-related research and teaching efforts in U.S.A. and Canadian university animal sciences departments (agriculture) and veterinary medical colleges. The objectives of the eleven questions of the survey were to identify behavior workers and to determine the current and planned levels of emphasis on research and teaching activities in domestic animal behavior. During 1981, questionnaires were mailed to 162 deans and chairmen, and 102 were answered and returned. Twenty-three persons were identified as having appointments specifically or primarily in animal behavior, and 99 persons were identified as having appointments that had some responsibilities …

Prostaglandin F2a Induced Nest Building Behavior In The Non-Pregnant Sow, And Some Welfare Considerations, Judith K. Blackshaw

Agribusiness Collection

Nest building behavior, induced with intramuscular injections of prostaglandin F2_a (PGF2_a), was studied in non-pregnant sows. Acute effects, which included salivation, scratching, vomiting, defaecation and ataxia, were also recorded. Sows (Large White x Landrace) were housed in two different environments; six sows in bare pens and six sows in pens provided with bedding material. In all cases except one (bare pen) nest building sequences of differing intensities were recorded. Welfare suggestions include questioning the justification of using a drug (PGF2_a) in pig husbandry, which has unpleasant acute effects, and the suggestion that the provision of …

Vivisection And Misanthropy, George P. Cave

Experimentation Collection

Goodman recognizes that it is reasonable to question whether all experiments performed on animals really contribute to human welfare, and he even concedes that the use of animals in laboratories "could no doubt be reduced further without harm to humankind." On the other hand, it is quite clear that he is completely unaware of the sheer quantity of absolutely worthless experiments currently being conducted, ,and that he subscribes to the popular misconception, deliberately perpetrated by the research establishment, that animal experimentation is coextensive with biomedical research, thereby contributing directly to human welfare through the conquering of disease. Furthermore, Goodman seems …

Chemical Efficacy Trials, E Carter

Experimental Summaries - Plant Research

Please find attached summaries for the following six chemical efficacy trials:- 83PE51 - Control of powdery scab of potatoes. 83MD7 - Control of early blight of tomatoes. 83MD11 - Control of sclerotinia in lettuce. 83MD12 - Control of secondary black rot in cabbage. 83MD13 - Control of tuber-borne Rhizoctonia solari of potatoes. 83MD14 - Control of downy mildew of onions. The following trial has not yet been harvested:- 83MD15 - Chemical control of onion smudge.

Ua35/11 Student Honors Research Bulletin, Wku Honors Program

WKU Archives Records

The WKU Student Honors Research Bulletin is dedicated to scholarly involvement and student research. These papers are representative of work done by students from throughout the university.

• Albin, Bettye. John Dryden's Criticism: The Neglected Link
• Allen, Christopher. Martial Reflections: Ancient Cultures and Their War-Gods
• Case, Laura. Climatic Preference
• Deller, Kathy. Regression Analysis: The Effects of Advertising, Price, Income and Import Sales on American-Made Auto Sales
• Downing, Elizabeth. Dorothy Leigh Sayers: Detective of Literary Theory in The Mind of the Maker
• Elder, Janice. A Retrospective Study on Discharge Planning and Primiparas at Breckinridge Memorial
• Flora, Joan. Narcissism and the Need for …

United States Naval Medical Research Unit Number Three, Cairo, Egypt, Medical Zoology Department Translation List, Harry Hoogstraal

United States Naval Medical Research Unit 3: Publications

List of translations of medical parasitology and medical entomology papers prepared by the United States Naval Medical Research Unit Number 3 in Cairo, Egypt. The papers were translated from numerous languages, such as Russian (most were translated from Russian), Bulgarian, Chinese, Czech, Finnish, French, German, and Japanese, into English. The publication dates of the original papers ranged from about 1915 to 1983. Harry Hoogstraal translated some or all of the papers.

Survey Of Fungi Associated With Diseased Lupin Roots, M Sweetingham

Experimental Summaries - Plant Research

1. Survey of fungi associated with diseased lupin-roots. Cylindrocarpon was only encountered on the south coast (Albany and Esperance districts). The isolates were identified as c. didymum and c. destructans. At certain sites in the two northern districts (Geraldton and Moora) a distinct type of disorder, characterised by reddish-brown coloured lesions which develop on the below ground portion of the hypocotyl, was observed. 2. Assessment of lupin root disease in lupin permanent disease nurseries – 78WH20, 78BA51, 78C34, 78MT38, 80E21. 3. Effect of fungicide drenches on lupin root rots – 83MT17, 83WH9. 4. Mini plot seed treatment trials on lupins …

Toxic Ferns Of Western Australia, T E H Aplin, P Steele, M C. Nottle

Technical Bulletins

Botanical descriptions and notes on the distribution of six species of ferns are given. These plants contain the enzyme thiaminase, which may induce thiamin deficiency, or other constituents toxic to animals. The clinical signs of both thiamin deficiency and fern toxicity in affected livestock are described.

Summary Of Medic-Rhizobium Field Experiments, J G. Howieson

Experimental Summaries - Plant Research

83ME9 - Nutrition of R. meliloti in acid soil. - Meaningful results only available in 1984/85 Summary of Medic-Rhizobium Field Experiments 1983/84. 83ME87 - Effect of pH of culture conditions on survival in, and colonisation of, an acid soil by R. meliloti. - Meaningful results available 1984/85. (82ME22, 82ME22A, 82ME23) Survival and colonisation of acid soils by 18 strains of R. meliloti in association with 6 Medicago hosts. - Results discussed in this summary.