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Full-Text Articles in Life Sciences
A Medicated Dry Foam For Local Therapy In Infected Burns, Patrick Nicholas Catania
A Medicated Dry Foam For Local Therapy In Infected Burns, Patrick Nicholas Catania
University of the Pacific Theses and Dissertations
Local burn therapy usually includes the application of medicated ointments and dressings in order to minimize and eradicate infection. As this approach to local therapy may present problems regarding application and removal techniques, it was the purpose of this study to formulate a topical dosage form that may be applied to denuded areas of the skin without inunction. Using the concept of topical films, a dosage form was formulated that is highly water soluble, flexible , and adherent to both denuded and intact areas of the skin.
Anticoagulant Half-Life Of Heparin In Human Subjects With Normal And Impaired Renal Function., Paul James Perry
Anticoagulant Half-Life Of Heparin In Human Subjects With Normal And Impaired Renal Function., Paul James Perry
University of the Pacific Theses and Dissertations
Numerous investigators have noted that individuals vary widely in their response to the anticoagulant, heparin. Animal model3 have suggested that patients with depressed renal function would be expected to clear heparin from the blood at a slower rate than patients with normal renal function.
Utilizing the Activated Coagulation Time clotting test, a method was developed to determine the anticoagulant half-life of heparin. The study calculated the half-life of heparin in a group of individuals with normal renal function and a population of patients in chronic renal failure. Intravenous heparin doses of 0,3 units/ml and 0.6 units/ml of blood were administered …