Open Access. Powered by Scholars. Published by Universities.®
- Keyword
-
- Breast (7)
- Food habits (4)
- Air (3)
- Air quality (3)
- Food preferences (3)
-
- Gene expression (3)
- Immunoglobulins (3)
- Malaria (3)
- Mesenchyme (3)
- Mohawk Indians (3)
- Non-coding RNA (3)
- Obesity (3)
- Polychlorinated biphenyls (3)
- Anopheles (2)
- Breast cancer (2)
- Carcinogenesis (2)
- Cardiovascular system (2)
- Cytochrome P-450 (2)
- Diabetes (2)
- Drinking water (2)
- Drug resistance in microorganisms (2)
- Environmental health (2)
- Epithelium (2)
- Fertilization in vitro (2)
- Fetus (2)
- Fluorescence spectroscopy (2)
- Fruit in human nutrition (2)
- Glycoproteins (2)
- Glycosylation (2)
- Immunity (2)
- Publication Year
- Publication
- Publication Type
Articles 1 - 30 of 70
Full-Text Articles in Life Sciences
Evaluating The Health Impacts Of Fruit And Vegetable Intake At The Individual Level And Food Pantry Level Among Food Pantry Users, Jiacheng Chen
Evaluating The Health Impacts Of Fruit And Vegetable Intake At The Individual Level And Food Pantry Level Among Food Pantry Users, Jiacheng Chen
Legacy Theses & Dissertations (2009 - 2024)
Background: Chronic diseases impose heavy burdens on individuals and the healthcare system in the US. Many factors were found to be associated with chronic diseases, including demographics, family history, social environmental factors, and individual behavioral factors such as diet and physical activity. Among those factors, fruit and vegetable intake can have substantial health impacts via a variety of causal pathways. Fruit and vegetable (F&V) consumption is generally lower among individuals living in households experiencing food insecurity and rely on food assistance programs. Decreased F&V intake among food pantry users may negatively impact health. However, conducting quantitative analysis on this population …
Environmental Factors And Human Health Interactions : Ultrafine Particles, Temperature Variability, And Proximity To Power Stations, Ian Ryan
Legacy Theses & Dissertations (2009 - 2024)
Background: Air pollution leads to more than four million premature deaths worldwide and nearly 200,000 in the US each year. While there is extensive research relating PM2.5 to hospital visits for various health outcomes, there is relatively little research on ultrafine particles (UFPs), a particularly small and dangerous air pollutant. Another important exposure is temperature due to its association with dehydration, heat stress, and cardiovascular-related hospital admissions. However, relatively little research has been conducted on diurnal temperature range (DTR), or the range of temperature within a single day, which is an important indicator of climate change. Importantly, the interaction between …
Cis-Acting Super-Enhancer Lncrnas As Biomarkers To Early-Stage Breast Cancer, Ali Salman Ropri
Cis-Acting Super-Enhancer Lncrnas As Biomarkers To Early-Stage Breast Cancer, Ali Salman Ropri
Legacy Theses & Dissertations (2009 - 2024)
Abstract
Disability In An American Indian Community : Prevalence, Distribution, And The Role Of Polychlorinated Biphenyls, Thoin Farzana Begum
Disability In An American Indian Community : Prevalence, Distribution, And The Role Of Polychlorinated Biphenyls, Thoin Farzana Begum
Legacy Theses & Dissertations (2009 - 2024)
The Akwesasne reservation along the St. Lawrence River has experienced significant exposure to several persistent organic pollutants due to rapid industrialization. The Aluminum Company of America, General Motors, and Reynolds Metals operated aluminum foundries that used polychlorinated biphenyls (PCBs) as hydraulic fluids, which contaminated the community environment, the soil, air and water, and community food sources with PCBs. We administered the World Health Organization Disability Assessment Schedule II (WHODAS II) to 119 Akwesasne Mohawk adults residing along the St. Lawrence River in New York. We used exploratory factor analysis to summarize the 36- items comprising the WHODAS II. The 7 …
Food Environment, Food Acquisition Behavior, And Fruit And Vegetable Consumption Among Burmese Immigrants And Refugees : A Socio-Ecological Study, Hnin Wai Lwin Myo
Food Environment, Food Acquisition Behavior, And Fruit And Vegetable Consumption Among Burmese Immigrants And Refugees : A Socio-Ecological Study, Hnin Wai Lwin Myo
Legacy Theses & Dissertations (2009 - 2024)
Background: Using the framework of the Socio-Ecological Model, the current study aimed to investigate the associations between nutritional knowledge, food environment, food acquisition behavior, and daily recommended fruit and vegetable consumption (≥5 cups of fruits and vegetables) among Burmese refugees and immigrants in the Capital Region, New York. Methods: During July - November 2018, a cross-sectional survey with face-to-face interviews was conducted among Burmese refugees and immigrants aged 18 years and older living in Albany and Rensselaer counties (n=173, 52.0% female, mean age = 42.8). Daily recommended fruit and vegetable consumption was determined as ≥5 cups of fruit and vegetable …
Disability In An American Indian Community : Prevalence, Distribution, And The Role Of Polychlorinated Biphenyls, Thoin F. Begum
Disability In An American Indian Community : Prevalence, Distribution, And The Role Of Polychlorinated Biphenyls, Thoin F. Begum
Legacy Theses & Dissertations (2009 - 2024)
Phthalates have been implicated as reproductive toxicants in animal models and in human populations. This study examined associations between potential exposure sources and urinary phthalate concentrations among couples undergoing infertility treatment. Women (n=56) and their male partners (n=43) undergoing in vitro fertilization (IVF) were enrolled in a prospective cohort investigation of environmental chemicals and IVF outcomes at an academic medical center. On the day of oocyte retrieval, participants provided urine samples and completed questionnaires detailing use of personal care products (PCPs), and consumption of medications, foods, and beverages in the preceding 24-hours. Urine was analyzed for MEP, MBP, MPP, MHxP, …
Genomic Epidemiology Of Clinical Salmonella Enterica In New Hampshire, 2017-2020, Madison R. Turcotte
Genomic Epidemiology Of Clinical Salmonella Enterica In New Hampshire, 2017-2020, Madison R. Turcotte
Legacy Theses & Dissertations (2009 - 2024)
Antimicrobial resistance in Salmonella enterica remains a challenging public health threat. We aim to characterize the population structure and evolutionary history of 394 genomes of S. enterica isolates recovered from human clinical cases in New Hampshire, USA from 2017 to 2020. The population is phylogenetically diverse, consisting of 78 STs and 67 serotypes. We detected 61 genes associated with resistance to14 different antimicrobial classes. Rather than a single multidrug resistant clone expanding in the state, we found multiple lineages carrying different combinations of independently acquired resistance determinants. New or emerging lineages can therefore rapidly spread over relatively short timeframes. In …
Using Machine Learning To Predict Super-Utilizers Of Healthcare Services, Kevin Paul Buchan Jr.
Using Machine Learning To Predict Super-Utilizers Of Healthcare Services, Kevin Paul Buchan Jr.
Legacy Theses & Dissertations (2009 - 2024)
In this dissertation, I aim to forecast high utilizers of emergency care and inpatient Medicare services (i.e., healthcare visits). Through a literature review, I demonstrate that accurate and reliable prediction of these future high utilizers will not only reduce healthcare costs but will also improve the overall quality of healthcare for patients. By identifying this population at risk before manifestation, I propose that there is still time to reverse undesirable healthcare trajectories (i.e., individuals whose clinical risk increases an excessive healthcare and treatment burden) through timely attention and proper care coordination. My dissertation culminates in the delivery of state-of-the-art predictive …
Long Noncoding Rna Ak001796 As A Mediator Of Epithelial-To-Mesenchymal Transition In Metastatic Breast Cancer, Sumayya Adib Alchalabi
Long Noncoding Rna Ak001796 As A Mediator Of Epithelial-To-Mesenchymal Transition In Metastatic Breast Cancer, Sumayya Adib Alchalabi
Legacy Theses & Dissertations (2009 - 2024)
Long noncoding RNAs (lncRNAs) are emerging as key molecules regulating several cellular pathways and contributing to the development and progression of different diseases including cancer. The epithelial-to- mesenchymal transition (EMT), a molecular reprogramming process that plays a critical role in cancer metastasis, involves a complex interaction between protein coding and non-coding transcripts including lncRNAs. Understanding the biological significance of those lncRNAs of relatively unknown function, may help to uncover potential therapeutic targets for the aggressive subtypes of breast and other cancers. In this study, we examined the expression profiles of more than 17,000 lncRNAs in a large set of patients’ …
Mapping Of Auditory Cortical Functions Using Electrocorticography, James Robert Swift
Mapping Of Auditory Cortical Functions Using Electrocorticography, James Robert Swift
Legacy Theses & Dissertations (2009 - 2024)
Communication is a dynamic process through which we translate our inner thoughts in such a way that they can be shared with another person. This complex neurological phenomenon is a key predictor of our productivity and health. When our ability to communicate is compromised, our quality of life suffers. Although numerous methods to investigate the neuroscientific underpinnings of human language exist, our understanding of this process remains incomplete. Improving our understanding of where, when, and how auditory cortical activity occurs can enhance diagnostic techniques and improve treatment methods for neurological conditions that can impact auditory processing, such as epilepsy, or …
A Comparative Spatial And Climate Analysis Of Human Granulocytic Anaplasmosis And Human Babesiosis In New York State (2013-2018), Collin J. O'Connor
A Comparative Spatial And Climate Analysis Of Human Granulocytic Anaplasmosis And Human Babesiosis In New York State (2013-2018), Collin J. O'Connor
Legacy Theses & Dissertations (2009 - 2024)
Human granulocytic anaplasmosis (HGA) and human babesiosis are tick-borne diseases spread by Ixodes scapularis (the blacklegged or deer tick) and are the result of infection with Anaplasma phagocytophilum and Babesia microti, respectively. In New York State (NYS), incidence rates of these diseases increased concordantly until around 2013, when rates of HGA began to increase more rapidly than human babesiosis, and the spatial extent of the diseases diverged. Surveillance data of tick-borne pathogens (2007 to 2018) and reported human cases of HGA (n=4,297) and human babesiosis (n=2,986) (2013 to 2018) from the New York State Department of Health (NYSDOH) showed a …
Targeting The Rage Signaling Pathway To Ameliorate The Complications Of Diabetes, Stephen James Dansereau
Targeting The Rage Signaling Pathway To Ameliorate The Complications Of Diabetes, Stephen James Dansereau
Legacy Theses & Dissertations (2009 - 2024)
Diabetes is a global health epidemic that can be devastating to those afflicted,
Alterations In Corticotropin-Releasing Factor Receptor Type 1 In The Hypothalamus And Preoptic Area During The Postpartum Period, Rose Ann M. De Guzman
Alterations In Corticotropin-Releasing Factor Receptor Type 1 In The Hypothalamus And Preoptic Area During The Postpartum Period, Rose Ann M. De Guzman
Legacy Theses & Dissertations (2009 - 2024)
Despite the apparent sex difference in prevalence of anxiety in humans, pre-clinical studies that have led to anxiolytic drug discoveries between 1960 and 2012 used male animals and approximately 6% of 10,000 studies used female animals. The generalizability of the efficacy of these drugs to both sexes may be limited if data derived are predominantly based on the male brain. The purpose of this dissertation, therefore, was to investigate potential underlying neuronal mechanisms that could be contributing to the sex differences in stress-related mood disorder prevalence and to focus on shedding light on female brains.
Establishment Of A Murine Pro-Acinar Cell Line To Characterize Roles For Fgf2 And Α3Β1 Integrins In Regulating Pro-Acinar Characteristics, Renée F. Thiemann, Deirdre A. Nelson, C. Michael Dipersio, Melinda Larsen, Susan E. Laflamme
Establishment Of A Murine Pro-Acinar Cell Line To Characterize Roles For Fgf2 And Α3Β1 Integrins In Regulating Pro-Acinar Characteristics, Renée F. Thiemann, Deirdre A. Nelson, C. Michael Dipersio, Melinda Larsen, Susan E. Laflamme
Biological Sciences Faculty Scholarship
Radiation therapy for head and neck cancers results in permanent damage to the saliva producing acinar compartment of the salivary gland. To date, a pure pro-acinar cell line to study underlying mechanisms of acinar cell diferentiation in culture has not been described. Here, we report the establishment of a pro-acinar (mSG-PAC1) and ductal (mSG-DUC1) cell line, from the murine submandibular salivary gland (SMG), which recapitulate developmental milestones in diferentiation. mSG-DUC1 cells express the ductal markers, keratin-7 and keratin-19, and form lumenized spheroids. mSG-PAC1 cells express the pro-acinar markers SOX10 and aquaporin-5. Using the mSG-PAC1 cell line, we demonstrate that FGF2 …
The Effect Of Maternal Dietary Habits During Pregnancy On Neonate Leptin Methylation Patterns And Gestational Age, Sean Fitzpatrick
The Effect Of Maternal Dietary Habits During Pregnancy On Neonate Leptin Methylation Patterns And Gestational Age, Sean Fitzpatrick
Legacy Theses & Dissertations (2009 - 2024)
The health of a newborn baby is inextricably linked to the health status of its mother and in turn the mother’s diet during pregnancy. Leptin (LEP) is an adipokine hormone involved in metabolism regulation and has been linked fetal development through the hypothalamic-pituitary-adrenal axis (HPA). Prior work suggests that gestational epigenetic alterations the LEP gene may be sensitive to adverse exposures during pregnancy, which in turn could explain variation in neonate outcomes. However, no prior work has examined this possibility explicitly. The objective of this study was to investigate the association between dietary patterns of mothers during pregnancy and their …
Environmental Influences On Rates Of Osteo- And Rheumatoid Arthritis, Azad Abdulrahman Mohammed
Environmental Influences On Rates Of Osteo- And Rheumatoid Arthritis, Azad Abdulrahman Mohammed
Legacy Theses & Dissertations (2009 - 2024)
Abstract
The Effect Of Anthropogenic Environmental Modifications On Malaria Vectors In Amazonian Peru And Brazil, Catharine Prussing
The Effect Of Anthropogenic Environmental Modifications On Malaria Vectors In Amazonian Peru And Brazil, Catharine Prussing
Legacy Theses & Dissertations (2009 - 2024)
Malaria is the most deadly vector borne disease, causing substantial morbidity and hundreds of thousands of deaths worldwide each year. In the Americas, the incidence of malaria has increased steadily since 2014. The factors driving continued malaria transmission are complex and highly variable across endemic areas. These factors include inadequate access and financial commitment to prevention, diagnosis, and treatment, and a failure to target interventions to heterogeneous malaria transmission patterns and vector populations. Nyssorhynchus darlingi (formerly Anopheles darlingi), the predominant malaria vector in Latin America, is known for behavioral, phenotypic, and genetic variability across its range, which allow it to …
Climate Change And Salmonella, New York State, Kevin Taylor Welch
Climate Change And Salmonella, New York State, Kevin Taylor Welch
Legacy Theses & Dissertations (2009 - 2024)
A study of climate change and Salmonella was conducted, serving as the evidence-based results for action to mitigate adverse Salmonella outcomes for the population of New York State (NYS), and to facilitate dissemination of findings in regard to validated approaches for broader use to mitigate climate change and adverse communicable disease outcomes in a variety of other settings. This study bolsters understanding of dynamic exposures and outcomes for improved and targeted public health approaches to localized climate change and communicable disease outcomes. The approach was developed and refined through continuously validated and calibrated methodology for the enhancement of disease control …
Mesenchymal Cells Affect Salivary Epithelial Cell Morphology On Pgs/Plga Core/Shell Nanofibers, Lauren Sfakis, Tim Kamaldinov, Alexander Khmaladze, Zeinab F. Hosseini, Deirdre A. Nelson, Melinda Larsen, James Castracane
Mesenchymal Cells Affect Salivary Epithelial Cell Morphology On Pgs/Plga Core/Shell Nanofibers, Lauren Sfakis, Tim Kamaldinov, Alexander Khmaladze, Zeinab F. Hosseini, Deirdre A. Nelson, Melinda Larsen, James Castracane
Biological Sciences Faculty Scholarship
Engineering salivary glands is of interest due to the damaging effects of radiation therapy and the autoimmune disease Sjögren’s syndrome on salivary gland function. One of the current problems in tissue engineering is that in vitro studies often fail to predict in vivo regeneration due to failure of cells to interact with scaffolds and of the single cell types that are typically used for these studies. Although poly (lactic co glycolic acid) (PLGA) nanofiber scaffolds have been used for in vitro growth of epithelial cells, PLGA has low compliance and cells do not penetrate the scaffolds. Using a core-shell electrospinning …
Fgf2-Dependent Mesenchyme And Laminin-111 Are Niche Factors In Salivary Gland Organoids, Zeinab F. Hosseini, Deirdre A. Nelson, Nicholas Moskwa, Lauren M. Sfakis, James Castracane, Melinda Larsen
Fgf2-Dependent Mesenchyme And Laminin-111 Are Niche Factors In Salivary Gland Organoids, Zeinab F. Hosseini, Deirdre A. Nelson, Nicholas Moskwa, Lauren M. Sfakis, James Castracane, Melinda Larsen
Biological Sciences Faculty Scholarship
Epithelial progenitor cells are dependent upon a complex 3D niche to promote their proliferation and differentiation during development, which can be recapitulated in organoids. The specific requirements of the niche remain unclear for many cell types, including the proacinar cells that give rise to secretory acinar epithelial cells that produce saliva. Here, using ex vivo cultures of E16 primary mouse submandibular salivary gland epithelial cell clusters, we investigated the requirement for mesenchymal cells and other factors in producing salivary organoids in culture. Native E16 salivary mesenchyme, but not NIH3T3 cells or mesenchymal cell conditioned medium, supported robust protein expression of …
Applying New Methodologies In Assessing Impact Of School Environment On Children's Health And Performance, Yi Lu
Legacy Theses & Dissertations (2009 - 2024)
School-age children spend substantial time at school, a setting that is more vulnerable to environmental problems. School environmental factors, such as indoor air quality (IAQ), has been shown to have a significant impact on students’ health and academic performance. However, several research gaps remain regarding school environmental research. Few studies have assessed both indoor and outdoor school environmental factors and their impact on student’s respiratory health on a large scale. This is partially due to the lack of application of methods able to handle highly correlated variables. Little is known about the potential mediators on the path between the school …
Nutrition Transition, Trace Elements In Nails, And Blood Pressure Along The Interoceanic Highway, Madre De Dios, Peru, Stacy M. Pettigrew
Nutrition Transition, Trace Elements In Nails, And Blood Pressure Along The Interoceanic Highway, Madre De Dios, Peru, Stacy M. Pettigrew
Legacy Theses & Dissertations (2009 - 2024)
The paving of the Interoceanic Highway (IOH) brought rapid development to the Madre de Dios (MDD) region in the Peruvian Amazon. Development brings concerns of toxic trace element exposures, and road development has been a major driver of the transition from traditional to calorie-dense processed ‘Western’ diets in lower and middle-income countries. Investigacion de Migracion, Ambiente, y Salud (IMAS) (Investigation of Migration, the Environment, and Health) is the first analysis of health, diet, and integrated toxic trace elements in nails in the region. In 2014 we collected household surveys from 310 households in 46 communities along the IOH and nails …
The Effects Of Pre-Pregnancy Tobacco Use On Food Cravings And Weight Gain In Pregnancy, Lauren E. Blau
The Effects Of Pre-Pregnancy Tobacco Use On Food Cravings And Weight Gain In Pregnancy, Lauren E. Blau
Legacy Theses & Dissertations (2009 - 2024)
Smoking cessation is associated with greater frequency of food cravings, even when controlling for body mass index. Recent studies have indicated similarities between obese women and women who smoke tobacco in mood states and food craving frequency. This is consistent with the common substrate hypothesis, which postulates that shared neural pathways mediate craving across multiple domains, and could explain why it is common for women attempting to quit smoking to gain weight. Smoking cessation prior to pregnancy is strongly encouraged due to the adverse effects of tobacco use on the developing fetus. Studies have shown that women who quit smoking …
A Novel Impedance Biosensor For Measurement Of Trans-Epithelial Resistance In Cells Cultured On Nanofiber Scaffolds, Robert A. Schramm, Matthew H. Koslow, Deirdre A. Nelson, Melinda Larsen, James Castracane
A Novel Impedance Biosensor For Measurement Of Trans-Epithelial Resistance In Cells Cultured On Nanofiber Scaffolds, Robert A. Schramm, Matthew H. Koslow, Deirdre A. Nelson, Melinda Larsen, James Castracane
Biological Sciences Faculty Scholarship
Nanofibrous scaffolds provide high surface area for cell attachment, and resemble the structure of the collagen fibers which naturally occur in the basement membrane and extracellular matrix. A label free and non-destructive method of assessing the interaction of cell tissue and scaffolds aids in the ability to discern the effective quality and magnitude of any scaffold modifications. Impedance cell spectroscopy is a biosensing method that employs a functional approach to assessing the cell monolayer. The electrical impedance barrier function of a cell monolayer represents the level of restriction to diffusion of charged species between all adjacent cells across an entire …
Chronic Arsenic Exposure In Nanomolar Concentrations Accelerates Senescent Phenotypes In Vitro, Heather M. Sabo
Chronic Arsenic Exposure In Nanomolar Concentrations Accelerates Senescent Phenotypes In Vitro, Heather M. Sabo
Biological Sciences
Arsenic is recognized as an environmental carcinogen, in which over 100 million individuals worldwide experience chronic exposure through contaminated drinking water. Arsenic exposure is linked to several health conditions, such as cancer, diabetes, skin lesions, immune dysfunction, and cardiovascular disease. Here we test the hypothesis that toxicants, such as arsenic, accelerate the program of senescence. Human (IMR-90) primary diploid fibroblasts were chronically exposed to arsenic at nanomolar concentrations and the impact on the expression of senescent-associated mRNAs was evaluated. IMR-90 cells were exposed either to untreated media or exposed to 130nM and 330nM AsCl3 supplemented media. RNA samples were extracted …
Lncrna Ak001796 Is Essential For The Survival Of Aggressive Breast Cancer Cells, Sumayya Adib Al-Chalabi
Lncrna Ak001796 Is Essential For The Survival Of Aggressive Breast Cancer Cells, Sumayya Adib Al-Chalabi
Legacy Theses & Dissertations (2009 - 2024)
Abstract:
Development And Characterization Of Novel Anti-Bat Monoclonal Antibodies For Studying Bat Immunity, Cailyn Cowan
Development And Characterization Of Novel Anti-Bat Monoclonal Antibodies For Studying Bat Immunity, Cailyn Cowan
Legacy Theses & Dissertations (2009 - 2024)
Abstract
Discovering Small Molecule Inhibitors Targeted To Ligand-Stimulated Rage-Diaph1 Signaling Transduction, Jinhong Pan
Discovering Small Molecule Inhibitors Targeted To Ligand-Stimulated Rage-Diaph1 Signaling Transduction, Jinhong Pan
Legacy Theses & Dissertations (2009 - 2024)
The receptor of advanced glycation end product (RAGE) is a multiligand receptor of the immunoglobulin superfamily of cell surface molecules, which plays an important role in immune responses. Full-length RAGE includes three extracellular immunoglobulin domains, a transmembrane domain and an intracellular domain. It is a pattern recognition receptor that can bind diverse ligands. NMR spectroscopy and x-ray crystallization studies of the extracellular domains of RAGE indicate that RAGE ligands bind by distinct charge- and hydrophobicity-dependent mechanisms. It is found that calgranulin binding to the C1C2 domain or AGEs binding to the V domain activates extracellular signaling, which triggers interactions of …
Genetic Counselor Workforce Trends In The United States : 2002 To 2016, Charlene J. Schulz
Genetic Counselor Workforce Trends In The United States : 2002 To 2016, Charlene J. Schulz
Legacy Theses & Dissertations (2009 - 2024)
The purpose of this study was to identify and measure trends in genetic counselor (GC) workforce supply in the United States from 2002 to 2016. Using data collected biennially from the National Society of Genetic Counselors’ Professional Status Survey (PSS), I calculated overall percent change in GC employment across specific work settings over the past 14 years. I also measured change in the relative percentage of GCs who provide direct patient counseling (i.e. clinical GCs) to determine if the percentage of clinical GCs decreased over time. Analyses were performed to determine if associations existed between GC work settings and 1) …
The Role Of N-Myc Downstream Regulated Gene 1 In Breast Cancer Lipid Metabolism, Christopher James Sevinsky
The Role Of N-Myc Downstream Regulated Gene 1 In Breast Cancer Lipid Metabolism, Christopher James Sevinsky
Legacy Theses & Dissertations (2009 - 2024)
Altered carbohydrate and lipid metabolism are increasingly well characterized hallmarks of aggressive breast cancers. While aerobic glycolysis, or “the Warburg effect”, is a well-established metabolic adaptation exploited by tumor cells, the understanding of unique aspects of cancer lipid metabolism lags behind. This is especially true regarding the coordination of complex lipid synthesis and trafficking pathways, which remains poorly understood. N-Myc Downstream Regulated Gene1 (NDRG1) is overexpressed in many solid tumors, but its function is unclear. The importance of NDRG1 is best exemplified by the effect of null mutations on human physiology: inactivating mutations give rise to the severe autosomal recessive …