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Laboratory and Basic Science Research
Loma Linda University Electronic Theses, Dissertations & Projects
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The Role Of Brn-3.2 In Retinal Ganglion Cell Differentiation, Jerin Marie Wright
The Role Of Brn-3.2 In Retinal Ganglion Cell Differentiation, Jerin Marie Wright
Loma Linda University Electronic Theses, Dissertations & Projects
Within the retina, the POU domain of transcription factors brn-3.0, brn-3.1, and brn-3.2 are present only in retinal ganglion cells. These genes are believed to be involved in establishing neural cell lineages in mammals. In this study brn-3.2 was examined by comparing the number of ganglion cells present during postnatal development in normal mice (+/+), in mice homozygous (-/-) for the brn-3.2 gene, and in adult mice with a heterozygous gene deletion (+/-) for brn-3.2. Optic nerve cross sections were imaged by electron microscopy, and axon profiles counted systematically by hand. These counts were then related to the nerve cross …
The Immunology Of Parturition, Ari Mayer Mackler
The Immunology Of Parturition, Ari Mayer Mackler
Loma Linda University Electronic Theses, Dissertations & Projects
Macrophage-derived factors have been implicated in the etiology of preterm labor but little is known about trafficking of this immune cell into the uterus or its regulation of uterine contractility in mice. Enhanced number and activation of macrophages was hypothesized to precede parturition. Studies characterized contractile activity and the distribution of macrophages in the uterus of C3/HeN mice before and after term (=day 19). Contractile activity by uterine strips on days 15 and 18 of pregnancy, the day of delivery, and 1 day postpartum indicate that an endogenous oscillator sustains high frequency contractions. Modest acceleration of the pacemaker occurred before …